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Generating quantitative binding landscapes through fractional binding selections combined with deep sequencing and data normalization

Nature communications, 2020-01, Vol.11 (1), p.297-297, Article 297

2020

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Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy

Biochemical journal, 2021-03, Vol.478 (5), p.1139-1157

2021

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Amyloid β structural polymorphism, associated toxicity and therapeutic strategies

Cellular and molecular life sciences : CMLS, 2021-12, Vol.78 (23), p.7185-7198

2021

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Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs)

Scientific reports, 2022-05, Vol.12 (1), p.8657-8657, Article 8657

2022

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Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

Cellular and molecular life sciences : CMLS, 2022-02, Vol.79 (2), p.113, Article 113

2022

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A Molecular Mechanism for Lipopolysaccharide Protection of Gram-negative Bacteria from Antimicrobial Peptides

The Journal of biological chemistry, 2005-03, Vol.280 (11), p.10378-10387

2005

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Developing a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy

Scientific reports, 2023-07, Vol.13 (1), p.11923-11923, Article 11923

2023

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A KLK4 proteinase substrate capture approach to antagonize PAR1

Scientific reports, 2021-08, Vol.11 (1), p.16170-13, Article 16170

2021

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Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies

Molecules (Basel, Switzerland), 2020-10, Vol.25 (20), p.4850

2020

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PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

Scientific reports, 2019-02, Vol.9 (1), p.1844-1844, Article 1844

2019

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The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils

Cellular and molecular life sciences : CMLS, 2021-03, Vol.78 (5), p.2145-2155

2021

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Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site

PloS one, 2021-11, Vol.16 (11), p.e0249616-e0249616

2021

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Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

BMC biology, 2018-08, Vol.16 (1), p.92-92, Article 92

2018

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A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity

The Journal of biological chemistry, 2017-09, Vol.292 (38), p.15777-15788

2017

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Exploring Peptide Membrane Interaction Using Surface Plasmon Resonance: Differentiation between Pore Formation versus Membrane Disruption by Lytic Peptides

Biochemistry (Easton), 2003-01, Vol.42 (2), p.458-466

2003

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Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin

PloS one, 2016-10, Vol.11 (10), p.e0163732-e0163732

2016

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MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS

Cell death & disease, 2018-01, Vol.9 (2), p.107-14, Article 107

2018

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Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Scientific reports, 2023-03, Vol.13 (1), p.5186-5186, Article 5186

2023

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New Lytic Peptides Based on the d,l-Amphipathic Helix Motif Preferentially Kill Tumor Cells Compared to Normal Cells

Biochemistry (Easton), 2003-08, Vol.42 (31), p.9346-9354

2003

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Aβ42 Double Mutant Inhibits Aβ42-Induced Plasma and Mitochondrial Membrane Disruption in Artificial Membranes, Isolated Organs, and Intact Cells

ACS chemical neuroscience, 2020-04, Vol.11 (7), p.1027-1037

2020

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A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and αvβ3 integrin for osteoporosis therapy

PLoS biology, 2018-08, Vol.16 (8), p.e2002979

2018

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Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Nature communications, 2018-09, Vol.9 (1), p.3935-10, Article 3935

2018

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Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers

Molecular oncology, 2023-11, Vol.17 (11), p.2337-2355

2023

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Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide

Cancer research (Chicago, Ill.), 2006-05, Vol.66 (10), p.5371-5378

2006

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Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma

Cancers, 2021-08, Vol.13 (16), p.3969

2021

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Generating quantitative binding landscapes through fractional binding selections combined with deep sequencing and data normalization

Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy

Amyloid β structural polymorphism, associated toxicity and therapeutic strategies

Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs)

Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

A Molecular Mechanism for Lipopolysaccharide Protection of Gram-negative Bacteria from Antimicrobial Peptides

Developing a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy

A KLK4 proteinase substrate capture approach to antagonize PAR1

Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma

The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils

Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site

Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity

Exploring Peptide Membrane Interaction Using Surface Plasmon Resonance: Differentiation between Pore Formation versus Membrane Disruption by Lytic Peptides

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin

MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS

Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

New Lytic Peptides Based on the d,l-Amphipathic Helix Motif Preferentially Kill Tumor Cells Compared to Normal Cells

Aβ42 Double Mutant Inhibits Aβ42-Induced Plasma and Mitochondrial Membrane Disruption in Artificial Membranes, Isolated Organs, and Intact Cells

A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and αvβ3 integrin for osteoporosis therapy

Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers

Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide

Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma

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