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Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins

Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (9), p.1540-1544

2018

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Development of Humanized Mice for the Study of Hepatitis C Virus Infection

Transplantation proceedings, 2006-05, Vol.38 (4), p.1181-1184

2006

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Purification of a NF1‐like DNA‐binding protein from rat liver and cloning of the corresponding cDNA

The EMBO journal, 1988-10, Vol.7 (10), p.3115-3123

1988

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Generation of interleukin‐6 receptor antagonists by molecular‐modeling guided mutagenesis of residues important for gp130 activation

The EMBO journal, 1994-03, Vol.13 (6), p.1357-1367

1994

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Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole-N-Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase

Journal of medicinal chemistry, 2005-07, Vol.48 (14), p.4547-4557

2005

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Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin M receptors

The Journal of biological chemistry, 1994-04, Vol.269 (15), p.10991-10995

1994

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In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

Journal of Virology, 2003-03, Vol.77 (6), p.3669-3679

2003

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Identification of Ciliary Neurotrophic Factor (CNTF) Residues Essential for Leukemia Inhibitory Factor Receptor Binding and Generation of CNTF Receptor Antagonists

Proceedings of the National Academy of Sciences - PNAS, 1996-08, Vol.93 (17), p.9247-9252

1996

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High circulating levels of biologically inactive IL‐6/SIL‐6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130

Clinical and experimental immunology, 2003-02, Vol.131 (2), p.355-363

2003

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Two distinct factors interact with the promoter regions of several liver‐specific genes

The EMBO journal, 1988-06, Vol.7 (6), p.1711-1719

1988

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Structural Basis for Resistance of the Genotype 2b Hepatitis C Virus NS5B Polymerase to Site A Non-Nucleoside Inhibitors

Journal of molecular biology, 2009-07, Vol.390 (5), p.1048-1059

2009

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Persistent Replication of Hepatitis C Virus Replicons Expressing the β-Lactamase Reporter in Subpopulations of Highly Permissive Huh7 Cells

Journal of Virology, 2003-03, Vol.77 (5), p.2928-2935

2003

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Structural analysis of the X‐linked gene encoding human glucose 6‐phosphate dehydrogenase

The EMBO journal, 1986-08, Vol.5 (8), p.1849-1855

1986

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Dominant negative effect of wild-type NS5A on NS5A-adapted subgenomic hepatitis C virus RNA replicon

Journal of general virology, 2004-07, Vol.85 (7), p.1867-1875

2004

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Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

Proceedings of the National Academy of Sciences - PNAS, 1997-06, Vol.94 (12), p.6456-6461

1997

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HCV antiviral resistance : the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase

Antiviral chemistry & chemotherapy, 2005, Vol.16 (4), p.225-245

2005

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Two distinct and independent sites on IL-6 trigger gp130 dimer formation and signalling

The EMBO journal, 1995-01, Vol.14 (9), p.1942-1951

1995

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Human hepatocytes in mice receiving pre-immune injection with human cord blood cells

Biochemical and biophysical research communications, 2005-01, Vol.326 (1), p.66-73

2005

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Conventional Protein Kinase C Inhibition Prevents Alpha Interferon-Mediated Hepatitis C Virus Replicon Clearance by Impairing STAT Activation

Journal of Virology, 2004-12, Vol.78 (23), p.12809-12816

2004

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Specific Recognition of Cruciform DNA by Nuclear Protein HMG1

Science (American Association for the Advancement of Science), 1989-02, Vol.243 (4894), p.1056-1059

1989

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Cis‐ and trans‐acting elements responsible for the cell‐specific expression of the human alpha 1‐antitrypsin gene

The EMBO journal, 1987-09, Vol.6 (9), p.2759-2766

1987

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Nonradioactive Receptor Binding Assay for Ciliary Neurotrophic Factor

Analytical biochemistry, 1994-09, Vol.221 (2), p.387-391

1994

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The Molecular Design of Human IL-6 Receptor Antagonists

Annals of the New York Academy of Sciences, 1995-07, Vol.762 (1), p.136-151

1995

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Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions

Biochemical journal, 1998-05, Vol.331 ( Pt 3) (3), p.695-702

1998

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Two distinct and independent sites on IL‐6 trigger gp 130 dimer formation and signalling

The EMBO journal, 1995-05, Vol.14 (9), p.1942-1951

1995

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Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins

Development of Humanized Mice for the Study of Hepatitis C Virus Infection

Purification of a NF1‐like DNA‐binding protein from rat liver and cloning of the corresponding cDNA

Generation of interleukin‐6 receptor antagonists by molecular‐modeling guided mutagenesis of residues important for gp130 activation

Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole-N-Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase

Oncostatin M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin M receptors

In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

Identification of Ciliary Neurotrophic Factor (CNTF) Residues Essential for Leukemia Inhibitory Factor Receptor Binding and Generation of CNTF Receptor Antagonists

High circulating levels of biologically inactive IL‐6/SIL‐6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130

Two distinct factors interact with the promoter regions of several liver‐specific genes

Structural Basis for Resistance of the Genotype 2b Hepatitis C Virus NS5B Polymerase to Site A Non-Nucleoside Inhibitors

Persistent Replication of Hepatitis C Virus Replicons Expressing the β-Lactamase Reporter in Subpopulations of Highly Permissive Huh7 Cells

Structural analysis of the X‐linked gene encoding human glucose 6‐phosphate dehydrogenase

Dominant negative effect of wild-type NS5A on NS5A-adapted subgenomic hepatitis C virus RNA replicon

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

HCV antiviral resistance : the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase

Two distinct and independent sites on IL-6 trigger gp130 dimer formation and signalling

Human hepatocytes in mice receiving pre-immune injection with human cord blood cells

Conventional Protein Kinase C Inhibition Prevents Alpha Interferon-Mediated Hepatitis C Virus Replicon Clearance by Impairing STAT Activation

Specific Recognition of Cruciform DNA by Nuclear Protein HMG1

Cis‐ and trans‐acting elements responsible for the cell‐specific expression of the human alpha 1‐antitrypsin gene

Nonradioactive Receptor Binding Assay for Ciliary Neurotrophic Factor

The Molecular Design of Human IL-6 Receptor Antagonists

Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions

Two distinct and independent sites on IL‐6 trigger gp 130 dimer formation and signalling

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