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Copper-Facilitated Suzuki Reactions: Application to 2-Heterocyclic Boronates

Organic letters, 2009-01, Vol.11 (2), p.345-347

2009

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Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists

Bioorganic & medicinal chemistry letters, 2024-11, Vol.112, p.129944, Article 129944

2024

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Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells

Respiratory research, 2024-07, Vol.25 (1), p.269-10, Article 269

2024

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Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine

The Journal of pharmacology and experimental therapeutics, 2008-02, Vol.324 (2), p.416-421

2008

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Enantioselective Total Syntheses of Ditryptophenaline and ent-WIN 64821

Journal of the American Chemical Society, 2001-09, Vol.123 (38), p.9465-9467

2001

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Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders

Frontiers in immunology, 2024-10, Vol.15

2024

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Direct Stereo- and Enantiocontrolled Synthesis of Vicinal Stereogenic Quaternary Carbon Centers. Total Syntheses of meso- and (−)-Chimonanthine and (+)-Calycanthine

Journal of the American Chemical Society, 1999-08, Vol.121 (33), p.7702-7703

1999

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Total Synthesis of (−)-Cylindrocyclophanes A and F Exploiting the Reversible Nature of the Olefin Cross Metathesis Reaction

Journal of the American Chemical Society, 2001-06, Vol.123 (25), p.5925-5937

2001

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Expanding the scope of the Cu assisted Suzuki–Miyaura reaction

Tetrahedron letters, 2011-09, Vol.52 (39), p.5055-5059

2011

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Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis

Bioorganic & medicinal chemistry letters, 2022-10, Vol.74, p.128927-128927, Article 128927

2022

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Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors

Bioorganic & medicinal chemistry letters, 2021-07, Vol.44, p.128082, Article 128082

2021

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Assembly of (−)-Cylindrocyclophanes A and F via Remarkable Olefin Metathesis Dimerizations

Journal of the American Chemical Society, 2000-05, Vol.122 (20), p.4984-4985

2000

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Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor

ACS medicinal chemistry letters, 2018-08, Vol.9 (8), p.815-820

2018

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Identification of second-generation P2X3 antagonists for treatment of pain

Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (8), p.1392-1396

2018

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Caprolactams as potent CGRP receptor antagonists for the treatment of migraine

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (17), p.4795-4798

2007

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Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (21), p.4777-4781

2015

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Synthesis of the (3R,6S)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache

Organic letters, 2008-08, Vol.10 (15), p.3235-3238

2008

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Examining the binding properties of MK-0974: A CGRP receptor antagonist for the acute treatment of migraine

European journal of pharmacology, 2009-01, Vol.602 (2), p.250-254

2009

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Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2359-2364

2011

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Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: Discovery of MK-2918

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (9), p.2683-2686

2011

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Calcitonin gene-related peptide receptor antagonists for the treatment of migraine: a patent review

Expert opinion on therapeutic patents, 2009-12, Vol.19 (12), p.1675-1713

2009

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Calcitonin gene-related peptide (CGRP) receptor antagonists: Investigations of a pyridinone template

Bioorganic & medicinal chemistry, 2008-01, Vol.18 (2), p.755-758

2008

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Total Synthesis of (−)-Cylindrocyclophane F

Journal of the American Chemical Society, 1999-08, Vol.121 (32), p.7423-7424

1999

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Synthesis of tri- and tetrasubstituted imidazoles

Tetrahedron letters, 2008-10, Vol.49 (42), p.6155-6159

2008

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Copper-Facilitated Suzuki Reactions: Application to 2-Heterocyclic Boronates

Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells

Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

Enantioselective Total Syntheses of Ditryptophenaline and ent-WIN 64821

Pharmacological blockade of the mast cell MRGPRX2 receptor supports investigation of its relevance in skin disorders

Direct Stereo- and Enantiocontrolled Synthesis of Vicinal Stereogenic Quaternary Carbon Centers. Total Syntheses of meso- and (−)-Chimonanthine and (+)-Calycanthine

Total Synthesis of (−)-Cylindrocyclophanes A and F Exploiting the Reversible Nature of the Olefin Cross Metathesis Reaction

Expanding the scope of the Cu assisted Suzuki–Miyaura reaction

Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis

Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors

Assembly of (−)-Cylindrocyclophanes A and F via Remarkable Olefin Metathesis Dimerizations

Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor

Identification of second-generation P2X3 antagonists for treatment of pain

Caprolactams as potent CGRP receptor antagonists for the treatment of migraine

Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine

Synthesis of the (3R,6S)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache

Examining the binding properties of MK-0974: A CGRP receptor antagonist for the acute treatment of migraine

Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia

Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: Discovery of MK-2918

Calcitonin gene-related peptide receptor antagonists for the treatment of migraine: a patent review

Calcitonin gene-related peptide (CGRP) receptor antagonists: Investigations of a pyridinone template

Total Synthesis of (−)-Cylindrocyclophane F

Synthesis of tri- and tetrasubstituted imidazoles

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