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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

Nature reviews. Drug discovery, 2014-06, Vol.13 (6), p.419-431

2014

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Impact of a five-dimensional framework on R&D productivity at AstraZeneca

Nature reviews. Drug discovery, 2018-03, Vol.17 (3), p.167-181

2018

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Molecular Cloning and Characterization of Two Novel Retinoic Acid-Inducible Orphan G-Protein-Coupled Receptors (GPRC5B and GPRC5C)

Genomics (San Diego, Calif.), 2000-07, Vol.67 (1), p.8-18

2000

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Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting

Molecular therapy, 2023-03, Vol.31 (3), p.866-874

2023

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Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (13), p.5161-5166

2006

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Rapamycin alleviates toxicity of different aggregate-prone proteins

Human molecular genetics, 2006-02, Vol.15 (3), p.433-442

2006

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Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival

The Journal of neuroscience, 2005-02, Vol.25 (6), p.1459-1469

2005

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Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease

The Journal of neuroscience, 2005-09, Vol.25 (39), p.8898-8902

2005

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Phospho-dependent binding of the clathrin AP2 adaptor complex to GABA A receptors regulates the efficacy of inhibitory synaptic transmission

Proceedings of the National Academy of Sciences - PNAS, 2005-10, Vol.102 (41), p.14871-14876

2005

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The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models

Journal of neuroscience methods, 2000-05, Vol.98 (1), p.9-20

2000

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GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer

The Journal of neuroscience, 2001-10, Vol.21 (20), p.8043

2001

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mRNA distribution analysis of human TRPC family in CNS and peripheral tissues

Brain research. Molecular brain research., 2002-12, Vol.109 (1), p.95-104

2002

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Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide

Biochemical Society transactions, 2005-08, Vol.33 (Pt 4), p.553-558

2005

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Cloning and Functional Expression of Human Short TRP7, a Candidate Protein for Store-operated Ca2+ Influx

The Journal of biological chemistry, 2002-04, Vol.277 (14), p.12302-12309

2002

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Methamphetamine-Evoked Depression of GABAB Receptor Signaling in GABA Neurons of the VTA

Neuron (Cambridge, Mass.), 2012-03, Vol.73 (5), p.978-989

2012

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Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice

Molecular and cellular neuroscience, 2001-06, Vol.17 (6), p.1059-1070

2001

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Localisation of the GPRC5B receptor in the rat brain and spinal cord

Brain research. Molecular brain research., 2002-10, Vol.106 (1), p.136-144

2002

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Marlin-1, a Novel RNA-binding Protein Associates with GABA Receptors

The Journal of biological chemistry, 2004-04, Vol.279 (14), p.13934-13943

2004

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Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling

Nature neuroscience, 2002-05, Vol.5 (5), p.415-424

2002

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The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling

The Journal of neuroscience, 2001-02, Vol.21 (4), p.1203

2001

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Overcoming the Inhibitors of Myelin with a Novel Neurotrophin Strategy

The Journal of biological chemistry, 2005-02, Vol.280 (7), p.5862-5869

2005

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Heteromeric assembly of GABA(B)R1 and GABA(B)R2 receptor subunits inhibits Ca(2+) current in sympathetic neurons

The Journal of neuroscience, 2000-04, Vol.20 (8), p.2867-2874

2000

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The expression of GABA(B1) and GABA(B2) receptor subunits in the cNS differs from that in peripheral tissues

Neuroscience, 2000-01, Vol.100 (1), p.155-170

2000

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Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery

Brain research. Molecular brain research., 2001-01, Vol.86 (1-2), p.101-114

2001

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Comparative immunohistochemical localisation of GABA(B1a), GABA(B1b) and GABA(B2) subunits in rat brain, spinal cord and dorsal root ganglion

Neuroscience, 2001, Vol.106 (3), p.447-467

2001

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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

Impact of a five-dimensional framework on R&D productivity at AstraZeneca

Molecular Cloning and Characterization of Two Novel Retinoic Acid-Inducible Orphan G-Protein-Coupled Receptors (GPRC5B and GPRC5C)

Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting

Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease

Rapamycin alleviates toxicity of different aggregate-prone proteins

Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease

Phospho-dependent binding of the clathrin AP2 adaptor complex to GABA A receptors regulates the efficacy of inhibitory synaptic transmission

The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer

mRNA distribution analysis of human TRPC family in CNS and peripheral tissues

Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide

Cloning and Functional Expression of Human Short TRP7, a Candidate Protein for Store-operated Ca2+ Influx

Methamphetamine-Evoked Depression of GABAB Receptor Signaling in GABA Neurons of the VTA

Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice

Localisation of the GPRC5B receptor in the rat brain and spinal cord

Marlin-1, a Novel RNA-binding Protein Associates with GABA Receptors

Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling

The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling

Overcoming the Inhibitors of Myelin with a Novel Neurotrophin Strategy

Heteromeric assembly of GABA(B)R1 and GABA(B)R2 receptor subunits inhibits Ca(2+) current in sympathetic neurons

The expression of GABA(B1) and GABA(B2) receptor subunits in the cNS differs from that in peripheral tissues

Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery

Comparative immunohistochemical localisation of GABA(B1a), GABA(B1b) and GABA(B2) subunits in rat brain, spinal cord and dorsal root ganglion

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