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The Biologic IRL201805 Alters Immune Tolerance Leading to Prolonged Pharmacodynamics and Efficacy in Rheumatoid Arthritis Patients

International journal of molecular sciences, 2024-04, Vol.25 (8), p.4394

2024

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Immunoglobulin heavy-chain-binding protein (BiP): a stress protein that has the potential to be a novel therapy for rheumatoid arthritis

Biochemical Society transactions, 2014-12, Vol.42 (6), p.1752

2014

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Real world long-term impact of intensive treatment on disease activity, disability and health-related quality of life in rheumatoid arthritis

BMC rheumatology, 2019-01, Vol.3 (1), p.6-6, Article 6

2019

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Binding Immunoglobulin Protein (BIP) Inhibits TNF‐α–Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model

ACR open rheumatology, 2019-08, Vol.1 (6), p.382-393

2019

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The Human Endoplasmic Reticulum Molecular Chaperone BiP Is an Autoantigen for Rheumatoid Arthritis and Prevents the Induction of Experimental Arthritis

The Journal of immunology (1950), 2001-02, Vol.166 (3), p.1492-1498

2001

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Safety and patient response as indicated by biomarker changes to binding immunoglobulin protein in the phase I/IIA RAGULA clinical trial in rheumatoid arthritis

Rheumatology (Oxford, England), 2016-11, Vol.55 (11), p.1993-2000

2016

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Binding immunoglobulin protein-treated peripheral blood monocyte-derived dendritic cells are refractory to maturation and induce regulatory T-cell development

Immunology, 2009-10, Vol.128 (2), p.218-226

2009

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Developments in the immunology of rheumatoid arthritis, a personal perspective

Rheumatology (Oxford, England), 2011-05, Vol.50 (5), p.815-817

Panayi, Gabriel S

2011

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Pro-resolution immunological networks: binding immunoglobulin protein and other resolution-associated molecular patterns

Rheumatology (Oxford, England), 2012-05, Vol.51 (5), p.780-788

2012

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Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice

Arthritis research & therapy, 2011-01, Vol.13 (5), p.R149-R149

2011

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A New-Age for Biologic Therapies: Long-Term Drug-Free Therapy with BiP?

Frontiers in immunology, 2012-01, Vol.3, p.17-17

2012

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Functional and work outcomes improve in patients with rheumatoid arthritis who receive targeted, comprehensive occupational therapy

Arthritis and rheumatism, 2009-11, Vol.61 (11), p.1522-1530

2009

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Even though T-cell-directed trials have been of limited success, is there reason for optimism?

Nature clinical practice. Rheumatology, 2006-02, Vol.2 (2), p.58-59

Panayi, Gabriel S

2006

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Stress cytokines: pivotal proteins in immune regulatory networks: Opinion

Current opinion in immunology, 2004-08, Vol.16 (4), p.531-534

2004

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B cell-directed therapy in rheumatoid arthritis--clinical experience

Journal of rheumatology. Supplement, 2005-02, Vol.73, p.19

Panayi, Gabriel S

2005

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Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI

The New England journal of medicine, 2017-05, Vol.376 (19), p.1813-1823

2017

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Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis

The New England journal of medicine, 2001-03, Vol.344 (12), p.907-916

2001

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Autoantigens and immune pathways in rheumatoid arthritis

Critical reviews in immunology, 2002, Vol.22 (4), p.281

2002

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Stromal Cell-Derived Factor 1 (CXCL12) Induces Human Cell Migration into Human Lymph Nodes Transplanted into SCID Mice

The Journal of immunology (1950), 2002-05, Vol.168 (9), p.4308-4317

2002

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BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis

Novartis Foundation symposium, 2008, Vol.291, p.212

2008

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Inhibition of antigen‐presenting cell function and stimulation of human peripheral blood mononuclear cells to express an antiinflammatory cytokine profile by the stress protein BiP: Relevance to the treatment of inflammatory arthritis

Arthritis and rheumatism, 2004-04, Vol.50 (4), p.1164-1171

2004

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Changes in disease characteristics and response rates among patients in the United Kingdom starting anti-tumour necrosis factor therapy for rheumatoid arthritis between 2001 and 2008

Rheumatology (Oxford, England), 2011-01, Vol.50 (1), p.117-123

2011

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Effectiveness of rituximab in patients with rheumatoid arthritis: observational study from the British Society for Rheumatology Biologics Register

Journal of rheumatology, 2012-02, Vol.39 (2), p.240

2012

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Inflammatory joint diseases: the province of rheumatologists

Trends in immunology, 2001, Vol.22 (1), p.16-16

Panayi, Gabriel S

2001

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The British Society for Rheumatology Biologics Register: 6 years on

Rheumatology (Oxford, England), 2008-10, Vol.47 (10), p.1441-1443

2008

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The Biologic IRL201805 Alters Immune Tolerance Leading to Prolonged Pharmacodynamics and Efficacy in Rheumatoid Arthritis Patients

Immunoglobulin heavy-chain-binding protein (BiP): a stress protein that has the potential to be a novel therapy for rheumatoid arthritis

Real world long-term impact of intensive treatment on disease activity, disability and health-related quality of life in rheumatoid arthritis

Binding Immunoglobulin Protein (BIP) Inhibits TNF‐α–Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model

The Human Endoplasmic Reticulum Molecular Chaperone BiP Is an Autoantigen for Rheumatoid Arthritis and Prevents the Induction of Experimental Arthritis

Safety and patient response as indicated by biomarker changes to binding immunoglobulin protein in the phase I/IIA RAGULA clinical trial in rheumatoid arthritis

Binding immunoglobulin protein-treated peripheral blood monocyte-derived dendritic cells are refractory to maturation and induce regulatory T-cell development

Developments in the immunology of rheumatoid arthritis, a personal perspective

Pro-resolution immunological networks: binding immunoglobulin protein and other resolution-associated molecular patterns

Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice

A New-Age for Biologic Therapies: Long-Term Drug-Free Therapy with BiP?

Functional and work outcomes improve in patients with rheumatoid arthritis who receive targeted, comprehensive occupational therapy

Even though T-cell-directed trials have been of limited success, is there reason for optimism?

Stress cytokines: pivotal proteins in immune regulatory networks: Opinion

B cell-directed therapy in rheumatoid arthritis--clinical experience

Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI

Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis

Autoantigens and immune pathways in rheumatoid arthritis

Stromal Cell-Derived Factor 1 (CXCL12) Induces Human Cell Migration into Human Lymph Nodes Transplanted into SCID Mice

BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis

Inhibition of antigen‐presenting cell function and stimulation of human peripheral blood mononuclear cells to express an antiinflammatory cytokine profile by the stress protein BiP: Relevance to the treatment of inflammatory arthritis

Changes in disease characteristics and response rates among patients in the United Kingdom starting anti-tumour necrosis factor therapy for rheumatoid arthritis between 2001 and 2008

Effectiveness of rituximab in patients with rheumatoid arthritis: observational study from the British Society for Rheumatology Biologics Register

Inflammatory joint diseases: the province of rheumatologists

The British Society for Rheumatology Biologics Register: 6 years on

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