UB Paderborn / Katalog / Suche / in CDI

Quality guidelines for oral drug candidates: dose, solubility and lipophilicity

Drug discovery today, 2016-10, Vol.21 (10), p.1719-1727

2016

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Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases

The Journal of pharmacology and experimental therapeutics, 2013-05, Vol.345 (2), p.260

2013

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Call for Papers: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery

ACS medicinal chemistry letters, 2023-12, Vol.14 (12), p.1607-1607

2023

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Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2493-2505

2009

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Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (23), p.7087-7091

2012

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Comparison of N, N′-diarylsquaramides and N, N′-diarylureas as antagonists of the CXCR2 chemokine receptor

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1713-1717

2007

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Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (9), p.3366-3369

2012

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Design, Synthesis, and Structure−Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists

Journal of medicinal chemistry, 2009-08, Vol.52 (16), p.5241-5252

2009

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3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3864-3867

2007

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Fluorescent styryl dyes FM1-43 and FM2-10 are muscarinic receptor antagonists: intravital visualization of receptor occupancy

The Journal of physiology, 2006-08, Vol.575 (1), p.23-35

2006

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N, N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (21), p.5513-5516

2006

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Discovery of potent and orally bioavailable N, N′-diarylurea antagonists for the CXCR2 chemokine receptor

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (17), p.4375-4378

2004

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Synthesis of Stereopentad Subunits of Zincophorin and Rifamycin-S through Use of Chiral Allenyltin Reagents

Journal of organic chemistry, 1998-05, Vol.63 (11), p.3701-3705

1998

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Radical Cyclizations of Acylgermanes. New Reagent Equivalents of the Carbonyl Radical Acceptor Synthon

Journal of the American Chemical Society, 1997-05, Vol.119 (21), p.4797-4804

1997

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Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists

Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6066-6069

2007

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Discovery of (3- endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4560-4562

2009

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M3 muscarinic acetylcholine receptor antagonists : SAR and optimization of bi-aryl amines

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1686-1690

2009

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Comparative Studies on the Synthesis of an anti,syn Stereotriad with Chiral Allenylstannane and Allenylindium Reagents

Journal of organic chemistry, 1997-08, Vol.62 (17), p.6001-6005

1997

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Enantioselective and Diastereoselective Additions of Allylic Stannanes to Aldehydes Promoted by a Chiral (Acyloxy)borane Catalyst

Journal of organic chemistry, 1998-06, Vol.63 (13), p.4381-4384

1998

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Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C

ACS medicinal chemistry letters, 2011-02, Vol.2 (2), p.142-147

2011

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Discovery of Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists

Journal of medicinal chemistry, 2008-08, Vol.51 (16), p.4866-4869

2008

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Discovery of Biphenyl Piperazines as Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists

Journal of medicinal chemistry, 2008-10, Vol.51 (19), p.5915-5918

2008

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Discovery of Novel l-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists

Journal of medicinal chemistry, 2009, Vol.52 (8), p.2493-2505

2009

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Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicycl o[3.2 .1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4560-4562

2009

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Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas

Bioorganic & medicinal chemistry letters, 2008-10, Vol.18 (20), p.5481-5486

2008

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Quality guidelines for oral drug candidates: dose, solubility and lipophilicity

Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases

Call for Papers: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery

Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists

Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups

Comparison of N, N′-diarylsquaramides and N, N′-diarylureas as antagonists of the CXCR2 chemokine receptor

Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists

Design, Synthesis, and Structure−Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists

3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists

Fluorescent styryl dyes FM1-43 and FM2-10 are muscarinic receptor antagonists: intravital visualization of receptor occupancy

N, N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

Discovery of potent and orally bioavailable N, N′-diarylurea antagonists for the CXCR2 chemokine receptor

Synthesis of Stereopentad Subunits of Zincophorin and Rifamycin-S through Use of Chiral Allenyltin Reagents

Radical Cyclizations of Acylgermanes. New Reagent Equivalents of the Carbonyl Radical Acceptor Synthon

Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists

Discovery of (3- endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

M3 muscarinic acetylcholine receptor antagonists : SAR and optimization of bi-aryl amines

Comparative Studies on the Synthesis of an anti,syn Stereotriad with Chiral Allenylstannane and Allenylindium Reagents

Enantioselective and Diastereoselective Additions of Allylic Stannanes to Aldehydes Promoted by a Chiral (Acyloxy)borane Catalyst

Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C

Discovery of Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists

Discovery of Biphenyl Piperazines as Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists

Discovery of Novel l-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists

Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicycl o[3.2 .1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas

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