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The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

Cancer research (Chicago, Ill.), 2015-09, Vol.75 (18), p.3865-3878

2015

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Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1440-1454

2016

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Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

Biochemical journal, 2015-03, Vol.466 (2), p.337-346

2015

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Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12957-12977

2020

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Development of small molecule inhibitors of BRPF1 and TRIM24 bromodomains

Drug discovery today. Technologies, 2016-03, Vol.19, p.65-71

Palmer, Wylie S.

2016

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Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Journal of medicinal chemistry, 2012-06, Vol.55 (12), p.5887-5900

2012

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Synthesis of Silirenes by Palladium-Catalyzed Transfer of Silylene from Siliranes to Alkynes

Organometallics, 1997-10, Vol.16 (22), p.4824-4827

1997

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Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

Epigenetics & chromatin, 2015-09, Vol.8 (1), p.37-37, Article 37

2015

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Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1486-1492

2013

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Palladium-Catalyzed Reactions of Di-tert-butylsiliranes with Electron-Deficient Alkynes and Investigations of the Catalytic Cycle

Organometallics, 2001-08, Vol.20 (17), p.3691-3697

2001

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Stereospecific Palladium-Catalyzed Reactions of Siliranes with Alkynes

Organometallics, 1997-03, Vol.16 (6), p.1097-1099

1997

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Stereospecific and Regioselective Isocyanide Insertions into Siliranes and Reactions of the Resulting Iminosilacyclobutanes

Journal of organic chemistry, 1999-03, Vol.64 (6), p.1843-1848

1999

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Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2A

Biochemical journal, 2015-03, Vol.466 (2), p.337-346

2015

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N-Arylpiperazinyl-N‘-propylamino Derivatives of Heteroaryl Amides as Functional Uroselective α1-Adrenoceptor Antagonists

Journal of medicinal chemistry, 1997-08, Vol.40 (17), p.2674-2687

1997

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Stereo- and Regiochemistry of Aldehyde Insertions into the C-Si Bonds of Siliranes

Journal of the American Chemical Society, 1995-10, Vol.117 (42), p.10575-10576

1995

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Stereo- and Regioselectivity of Reactions of Siliranes with Aldehydes and Related Substrates

Journal of organic chemistry, 1997-07, Vol.62 (14), p.4737-4745

1997

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On the utility of α-heteroatom substituted orthoesters in the Johnson Claisen rearrangement

Tetrahedron letters, 1994-07, Vol.35 (28), p.4951-4954

1994

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N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists

Journal of medicinal chemistry, 1997-08, Vol.40 (17), p.2674-2687

1997

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ChemInform Abstract: Palladium-Catalyzed Reactions of Di-tert-butylsiliranes with Electron-Deficient Alkynes and Investigations of the Catalytic Cycle

ChemInform, 2001-12, Vol.32 (50), p.no-no

2001

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ChemInform Abstract: Stereospecific and Regioselective Isocyanide Insertions into Siliranes and Reactions of the Resulting Iminosilacyclobutanes

ChemInform, 1999-08, Vol.30 (32), p.no-no

1999

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The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1

Nature (London), 2017-03, Vol.543 (7647), p.733-737

2017

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HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (51), p.E4987-E4996

2013

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Synovial sepsis is rare following intrasynovial medication in equine ambulatory practice

Equine veterinary journal, 2019-09, Vol.51 (5), p.595-599

2019

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Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort

American journal of obstetrics and gynecology, 2016-07, Vol.215 (1), p.103.e1-103.e14

2016

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The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

Development of small molecule inhibitors of BRPF1 and TRIM24 bromodomains

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Synthesis of Silirenes by Palladium-Catalyzed Transfer of Silylene from Siliranes to Alkynes

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead

Palladium-Catalyzed Reactions of Di-tert-butylsiliranes with Electron-Deficient Alkynes and Investigations of the Catalytic Cycle

Stereospecific Palladium-Catalyzed Reactions of Siliranes with Alkynes

Stereospecific and Regioselective Isocyanide Insertions into Siliranes and Reactions of the Resulting Iminosilacyclobutanes

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2A

N-Arylpiperazinyl-N‘-propylamino Derivatives of Heteroaryl Amides as Functional Uroselective α1-Adrenoceptor Antagonists

Stereo- and Regiochemistry of Aldehyde Insertions into the C-Si Bonds of Siliranes

Stereo- and Regioselectivity of Reactions of Siliranes with Aldehydes and Related Substrates

On the utility of α-heteroatom substituted orthoesters in the Johnson Claisen rearrangement

N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists

ChemInform Abstract: Palladium-Catalyzed Reactions of Di-tert-butylsiliranes with Electron-Deficient Alkynes and Investigations of the Catalytic Cycle

ChemInform Abstract: Stereospecific and Regioselective Isocyanide Insertions into Siliranes and Reactions of the Resulting Iminosilacyclobutanes

The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1

HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time

Synovial sepsis is rare following intrasynovial medication in equine ambulatory practice

Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort

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