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LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (14), p.4059-4072

2018

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ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors

Clinical cancer research, 2009-12, Vol.15 (23), p.7277-7290

2009

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ABBV-399, a c-Met Antibody-Drug Conjugate that Targets Both MET -Amplified and c-Met-Overexpressing Tumors, Irrespective of MET Pathway Dependence

Clinical cancer research, 2017-02, Vol.23 (4), p.992-1000

2017

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Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody–Drug Conjugate

Molecular cancer therapeutics, 2020-10, Vol.19 (10), p.2117-2125

2020

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The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo

Anticancer research, 2008-09, Vol.28 (5A), p.2625-2635

2008

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Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor

Clinical cancer research, 2012-01, Vol.18 (2), p.510-523

2012

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ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies

Molecular cancer therapeutics, 2023-08, Vol.22 (8), p.903-912

2023

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Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody

Molecular cancer therapeutics, 2015-05, Vol.14 (5), p.1141-1151

2015

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Antitumor Activity of Orally Bioavailable Farnesyltransferase Inhibitor, ABT-100, Is Mediated by Antiproliferative, Proapoptotic, and Antiangiogenic Effects in Xenograft Models

Clinical cancer research, 2005-04, Vol.11 (8), p.3045-3054

2005

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Infection with Theiler's Murine Encephalomyelitis Virus Directly Induces Proinflammatory Cytokines in Primary Astrocytes via NF-κB Activation: Potential Role for the Initiation of Demyelinating Disease

Journal of Virology, 2003-06, Vol.77 (11), p.6322-6331

2003

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A “Prozone-Like” Effect Influences the Efficacy of the Monoclonal Antibody ABT-700 against the Hepatocyte Growth Factor Receptor

Pharmacology, 2017-01, Vol.100 (5-6), p.229-242

2017

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Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (14), p.4750-4755

2012

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Pharmacodynamic Evaluation of Irinotecan Therapy by FDG and FLT PET/CT Imaging in a Colorectal Cancer Xenograft Model

Molecular imaging and biology, 2012-10, Vol.14 (5), p.617-624

2012

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The scope and activation mechanisms of chemokine gene expression in primary astrocytes following infection with Theiler's virus

Journal of neuroimmunology, 2004-04, Vol.149 (1), p.121-129

2004

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Pathogenesis of virus-induced immune-mediated demyelination

Immunologic research, 2001-01, Vol.24 (2), p.121-130

2001

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Induction of selected chemokines in glial cells infected with Theiler's virus

Journal of neuroimmunology, 2001-07, Vol.117 (1), p.166-170

2001

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Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP-1 and NF-κB

Glia, 2004-02, Vol.45 (3), p.287-296

2004

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Preferential Induction of IL-10 in APC Correlates with a Switch from Th1 to Th2 Response Following Infection with a Low Pathogenic Variant of Theiler's Virus

The Journal of immunology (1950), 2002-04, Vol.168 (8), p.4221-4230

2002

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Antibody response is required for protection from Theiler's virus-induced encephalitis in C57BL/6 mice in the absence of CD8 + T cells

Virology (New York, N.Y.), 2005-09, Vol.340 (1), p.84-94

2005

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Innate immune response induced by Theiler's murine encephalomyelitis virus infection

Immunologic research, 2005-01, Vol.31 (1), p.1-12

2005

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Immune profiling of the tumor microenvironment (TME) using multiplexed ion beam imaging (MIBI)

The Journal of immunology (1950), 2020-05, Vol.204 (1_Supplement), p.242-242.53

2020

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Potential Role of CD4+ T Cell-Mediated Apoptosis of Activated Astrocytes in Theiler's Virus-Induced Demyelination

The Journal of immunology (1950), 1999-06, Vol.162 (11), p.6543-6551

1999

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Effects of the major histocompatibility complex loci and T-cell receptor beta-chain repertoire on Theiler's virus-induced demyelinating disease

Journal of neuroscience research, 2005-09, Vol.81 (6), p.846-856

2005

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Role of Individual T-Cell Epitopes of Theiler’s Virus in the Pathogenesis of Demyelination Correlates with the Ability To Induce a Th1 Response

Journal of Virology, 1998-07, Vol.72 (7), p.6169-6174

1998

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LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors

ABBV-399, a c-Met Antibody-Drug Conjugate that Targets Both MET -Amplified and c-Met-Overexpressing Tumors, Irrespective of MET Pathway Dependence

Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody–Drug Conjugate

The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo

Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor

ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies

Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody

Antitumor Activity of Orally Bioavailable Farnesyltransferase Inhibitor, ABT-100, Is Mediated by Antiproliferative, Proapoptotic, and Antiangiogenic Effects in Xenograft Models

Infection with Theiler's Murine Encephalomyelitis Virus Directly Induces Proinflammatory Cytokines in Primary Astrocytes via NF-κB Activation: Potential Role for the Initiation of Demyelinating Disease

A “Prozone-Like” Effect Influences the Efficacy of the Monoclonal Antibody ABT-700 against the Hepatocyte Growth Factor Receptor

Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases

Pharmacodynamic Evaluation of Irinotecan Therapy by FDG and FLT PET/CT Imaging in a Colorectal Cancer Xenograft Model

The scope and activation mechanisms of chemokine gene expression in primary astrocytes following infection with Theiler's virus

Pathogenesis of virus-induced immune-mediated demyelination

Induction of selected chemokines in glial cells infected with Theiler's virus

Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP-1 and NF-κB

Preferential Induction of IL-10 in APC Correlates with a Switch from Th1 to Th2 Response Following Infection with a Low Pathogenic Variant of Theiler's Virus

Antibody response is required for protection from Theiler's virus-induced encephalitis in C57BL/6 mice in the absence of CD8 + T cells

Innate immune response induced by Theiler's murine encephalomyelitis virus infection

Immune profiling of the tumor microenvironment (TME) using multiplexed ion beam imaging (MIBI)

Potential Role of CD4+ T Cell-Mediated Apoptosis of Activated Astrocytes in Theiler's Virus-Induced Demyelination

Effects of the major histocompatibility complex loci and T-cell receptor beta-chain repertoire on Theiler's virus-induced demyelinating disease

Role of Individual T-Cell Epitopes of Theiler’s Virus in the Pathogenesis of Demyelination Correlates with the Ability To Induce a Th1 Response

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