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The Enzyme‐Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid

Angewandte Chemie International Edition, 2020-11, Vol.59 (45), p.20154-20160

International ed. in English, 2020

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Evoking picomolar binding in RNA by a single phosphorodithioate linkage

Nucleic acids research, 2016-09, Vol.44 (17), p.8052-8064

2016

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Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine

Nucleic acids research, 2020-10, Vol.48 (18), p.10101-10124

2020

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Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA

Journal of the American Chemical Society, 2017-06, Vol.139 (25), p.8537-8546

2017

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Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA

Nucleic acids research, 2011-04, Vol.39 (8), p.3482-3495

2011

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Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs

Angewandte Chemie (International ed.), 2011-03, Vol.50 (10), p.2284-2288

International ed. in English, 2011

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Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs

Nucleic acids research, 2014-06, Vol.42 (10), p.6542-6551

2014

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Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs

Chemical communications (Cambridge, England), 2012-01, Vol.48 (66), p.8195-8197

2012

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Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia

Molecular endocrinology (Baltimore, Md.), 2015-09, Vol.29 (9), p.1375-1384

2015

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Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

Journal of the American Chemical Society, 2011-10, Vol.133 (41), p.16642-16649

2011

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Crystallographic Studies of Chemically Modified Nucleic Acids: A Backward Glance

Chemistry & biodiversity, 2010-01, Vol.7 (1), p.60-89

2010

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An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

Journal of the American Chemical Society, 2010-10, Vol.132 (42), p.14942-14950

2010

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Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2′-Fluoro RNA

Journal of organic chemistry, 2012-06, Vol.77 (11), p.5074-5085

2012

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Molecular Dynamics Simulation of Homo-DNA: The Role of Crystal Packing in Duplex Conformation

Crystals (Basel), 2019-10, Vol.9 (10), p.532

2019

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Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System

Journal of the American Chemical Society, 2006-08, Vol.128 (33), p.10847-10856

2006

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Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex

Cell cycle (Georgetown, Tex.), 2008-08, Vol.7 (16), p.2562-2569

2008

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Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2‘-O-Ribonucleic Acid Modifications

Biochemistry (Easton), 2005-06, Vol.44 (25), p.9045-9057

2005

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Altering the Electrostatic Potential in the Major Groove: Thermodynamic and Structural Characterization of 7-Deaza-2′-deoxyadenosine:dT Base Pairing in DNA

The journal of physical chemistry. B, 2011-12, Vol.115 (47), p.13925-13934

2011

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Phosphorus SAD Phasing for Nucleic Acid Structures: Limitations and Potential

Crystals (Basel), 2016-10, Vol.6 (10), p.125-125

2016

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Conformational Morphing by a DNA Analogue Featuring 7‑Deazapurines and 5‑Halogenpyrimidines and the Origins of Adenine-Tract Geometry

Biochemistry (Easton), 2023-10, Vol.62 (19), p.2854-2867

2023

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Cryo neutron crystallography demonstrates influence of RNA 2′-OH orientation on conformation, sugar pucker and water structure

Nucleic acids research, 2022-07, Vol.50 (13), p.7721-7738

2022

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Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity

Angewandte Chemie International Edition, 2024-04, Vol.63 (15), p.e202319958-n/a

International ed. in English, 2024

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Conformation and Pairing Properties of an O6-Methyl-2′-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA

Chemical research in toxicology, 2022-08, Vol.35 (10), p.1903-1913

2022

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Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Nonionic Modifications Better than DNA

Journal of the American Chemical Society, 2009-10, Vol.131 (41), p.14932-14937

2009

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Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE

The Journal of biological chemistry, 2015-05, Vol.290 (21), p.13128-13143

2015

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The Enzyme‐Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid

Evoking picomolar binding in RNA by a single phosphorodithioate linkage

Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine

Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA

Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA

Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs

Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs

Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs

Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

Crystallographic Studies of Chemically Modified Nucleic Acids: A Backward Glance

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2′-Fluoro RNA

Molecular Dynamics Simulation of Homo-DNA: The Role of Crystal Packing in Duplex Conformation

Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System

Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex

Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2‘-O-Ribonucleic Acid Modifications

Altering the Electrostatic Potential in the Major Groove: Thermodynamic and Structural Characterization of 7-Deaza-2′-deoxyadenosine:dT Base Pairing in DNA

Phosphorus SAD Phasing for Nucleic Acid Structures: Limitations and Potential

Conformational Morphing by a DNA Analogue Featuring 7‑Deazapurines and 5‑Halogenpyrimidines and the Origins of Adenine-Tract Geometry

Cryo neutron crystallography demonstrates influence of RNA 2′-OH orientation on conformation, sugar pucker and water structure

Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity

Conformation and Pairing Properties of an O6-Methyl-2′-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA

Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Nonionic Modifications Better than DNA

Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE

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