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Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19

Scientific reports, 2022-06, Vol.12 (1), p.10174-10174, Article 10174

2022

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Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies

Clinical therapeutics, 2015-02, Vol.37 (2), p.311-324

2015

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Electroconvulsive Seizures Regulate Gene Expression of Distinct Neurotrophic Signaling Pathways

The Journal of neuroscience, 2004-03, Vol.24 (11), p.2667-2677

2004

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Synthesis and Structure–Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5‑HT2 Receptor Agonist

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6144-6188

2024

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Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT 2 Receptor Agonist

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6144-6188

2024

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Enzymes As Targets for Drug Design

Palfreyman, Michael

1, 1989

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The role of 5-HT2A receptors in antipsychotic activity

Life sciences (1973), 1995-05, Vol.56 (25), p.2209-2222

1995

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Human tissue in target identification and drug discovery

Drug discovery today, 2002-04, Vol.7 (7), p.407-409

Palfreyman, Michael G.

2002

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Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships

Journal of medicinal chemistry, 1985-02, Vol.28 (2), p.186-193

1985

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Compound Screening In A Drosophila melanogaster Alzheimer's Disease Model Using A Behavioral Readout

Alzheimer's & dementia, 2009-07, Vol.5 (4), p.e11-e12

2009

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Psychiatric Genomics, Inc

Pharmacogenomics, 2002-05, Vol.3 (3), p.417-420

Palfreyman, Michael G

2002

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Enzymes As Targets for Drug Design

Palfreyman, Michael G

2012

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Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2006-2006

2017

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Total Synthesis and Preliminary Antibacterial Evaluation of the RNA Polymerase Inhibitors (±)-Myxopyronin A and B

Journal of organic chemistry, 1998-04, Vol.63 (7), p.2401-2406

1998

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Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function

Psychopharmacology, 1993-03, Vol.112 (1 Suppl), p.S60-S67

1993

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Novel directions in antipsychotic target identification using gene arrays

Current drug targets. CNS & neurological disorders, 2002-04, Vol.1 (2), p.227-238

2002

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Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective [alpha]7Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies

Clinical therapeutics, 2015-02, Vol.37 (2), p.311

2015

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Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons

European journal of pharmacology, 1989-04, Vol.163 (1), p.115-118

1989

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Enzyme-Activated Antagonists of the Strychnine-Insensitive Glycine/NMDA Receptor

Journal of medicinal chemistry, 1994-02, Vol.37 (3), p.334-336

1994

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The relationship between GABA concentrations in brain and cerebrospinal fluid

Brain research, 1979-05, Vol.167 (2), p.297-305

1979

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P4‐279: Compound Screening In A Drosophila melanogaster Alzheimer's Disease Model Using A Behavioral Readout

Alzheimer's & dementia, 2009-07, Vol.5 (4S_Part_17), p.e11-e12

2009

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(E)-.beta.-(Fluoromethylene)-m-tyrosine: a substrate for aromatic L-amino acid decarboxylase liberating an enzyme-activated irreversible inhibitor of monoamine oxidase

Journal of the American Chemical Society, 1984-05, Vol.106 (11), p.3354-3356

1984

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Unsaturated heterocyclic amines as potent time-dependent inhibitors of dopamine .beta.-hydroxylase

Journal of medicinal chemistry, 1986-03, Vol.29 (3), p.315-317

1986

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Functional Genomics Conference: From Identifying Proteins to Faster Drug Discovery

Expert opinion on investigational drugs, 1998-07, Vol.7 (7), p.1201-1207

Palfreyman, Michael G

1998

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Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5-HT2 receptors

Drug development research, 1988, Vol.13 (1), p.29-43

1988

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Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19

Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies

Electroconvulsive Seizures Regulate Gene Expression of Distinct Neurotrophic Signaling Pathways

Synthesis and Structure–Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5‑HT2 Receptor Agonist

Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT 2 Receptor Agonist

Enzymes As Targets for Drug Design

The role of 5-HT2A receptors in antipsychotic activity

Human tissue in target identification and drug discovery

Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships

Compound Screening In A Drosophila melanogaster Alzheimer's Disease Model Using A Behavioral Readout

Psychiatric Genomics, Inc

Enzymes As Targets for Drug Design

Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer

Total Synthesis and Preliminary Antibacterial Evaluation of the RNA Polymerase Inhibitors (±)-Myxopyronin A and B

Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function

Novel directions in antipsychotic target identification using gene arrays

Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective [alpha]7Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies

Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons

Enzyme-Activated Antagonists of the Strychnine-Insensitive Glycine/NMDA Receptor

The relationship between GABA concentrations in brain and cerebrospinal fluid

P4‐279: Compound Screening In A Drosophila melanogaster Alzheimer's Disease Model Using A Behavioral Readout

(E)-.beta.-(Fluoromethylene)-m-tyrosine: a substrate for aromatic L-amino acid decarboxylase liberating an enzyme-activated irreversible inhibitor of monoamine oxidase

Unsaturated heterocyclic amines as potent time-dependent inhibitors of dopamine .beta.-hydroxylase

Functional Genomics Conference: From Identifying Proteins to Faster Drug Discovery

Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5-HT2 receptors

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