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C. elegans in high-throughput drug discovery

Advanced drug delivery reviews, 2014-04, Vol.69-70, p.247-253

2014

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Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

PloS one, 2010-11, Vol.5 (11), p.e15460

2010

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Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

British journal of cancer, 2017-11, Vol.118 (1), p.72-78

2017

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Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

International journal of molecular sciences, 2020-04, Vol.21 (8), p.2855

2020

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Quantitative assessment of cell fate decision between autophagy and apoptosis

Scientific reports, 2017-12, Vol.7 (1), p.17605-14, Article 17605

2017

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An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z

PloS one, 2019-01, Vol.14 (1), p.e0209748-e0209748

2019

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Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency

PloS one, 2014-01, Vol.9 (1), p.e87260-e87260

2014

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A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans

PloS one, 2012-07, Vol.7 (7), p.e40145

2012

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CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans

PloS one, 2019-03, Vol.14 (3), p.e0214257-e0214257

2019

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Disorders of Protein Misfolding: Alpha-1-Antitrypsin Deficiency as Prototype

The Journal of pediatrics, 2013-08, Vol.163 (2), p.320-326

2013

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SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

Communications biology, 2022-01, Vol.5 (1), p.46-46, Article 46

2022

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Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency

PloS one, 2015-10, Vol.10 (10), p.e0141542

2015

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Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

Communications biology, 2022-01, Vol.5 (1), p.47-25, Article 47

2022

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Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification

Biomolecules & Therapeutics, 2014, 22(5), , pp.371-383

2014

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Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

Nature neuroscience, 2022-11, Vol.25 (11), p.1420

2022

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Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

British journal of cancer, 2018-01, Vol.118 (1), p.72-78

2018

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A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C

Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (6), p.1

2022

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Functional analysis of a de novo variant in the neurodevelopment and generalized epilepsy disease gene NBEA

Molecular genetics and metabolism, 2021-09, Vol.134 (1-2), p.195-202

2021

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Serpins Flex Their Muscle: I. PUTTING THE CLAMPS ON PROTEOLYSIS IN DIVERSE BIOLOGICAL SYSTEMS

The Journal of biological chemistry, 2010-08, Vol.285 (32), p.24299-24305

2010

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Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z

Gastroenterology (New York, N.Y. 1943), 2022-07, Vol.163 (1), p.270-284

2022

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Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay

Molecular genetics and metabolism, 2022-05, Vol.136 (1), p.65-73

2022

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Serpins Flex Their Muscle: II. STRUCTURAL INSIGHTS INTO TARGET PEPTIDASE RECOGNITION, POLYMERIZATION, AND TRANSPORT FUNCTIONS

The Journal of biological chemistry, 2010-08, Vol.285 (32), p.24307-24312

2010

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A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency

Human molecular genetics, 2014-10, Vol.23 (19), p.5123-5132

2014

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SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin

Biochemistry (Easton), 2015-11, Vol.54 (45), p.6756-6759

2015

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C. elegans in high-throughput drug discovery

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis

Quantitative assessment of cell fate decision between autophagy and apoptosis

An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z

Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling

Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency

A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans

CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans

Disorders of Protein Misfolding: Alpha-1-Antitrypsin Deficiency as Prototype

SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation

Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification

Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer

A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C

Functional analysis of a de novo variant in the neurodevelopment and generalized epilepsy disease gene NBEA

Serpins Flex Their Muscle: I. PUTTING THE CLAMPS ON PROTEOLYSIS IN DIVERSE BIOLOGICAL SYSTEMS

Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z

Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay

Serpins Flex Their Muscle: II. STRUCTURAL INSIGHTS INTO TARGET PEPTIDASE RECOGNITION, POLYMERIZATION, AND TRANSPORT FUNCTIONS

A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency

SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin

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