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RNA interference mediated in human primary cells via recombinant baculoviral vectors

Molecular therapy, 2005-04, Vol.11 (4), p.638-644

2005

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Activation of signalling pathways during hepatocyte isolation: relevance to toxicology in vitro

Toxicology in vitro, 2004-04, Vol.18 (2), p.187-193

2004

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Developmental changes in the constitutive and inducible expression of cytochrome p450 3a2

Biochemical pharmacology, 1997-10, Vol.54 (7), p.841-846

1997

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Fibronectin-Mediated Hepatocyte Shape Change Reprograms Cytochrome P450 2C11 Gene Expression via an Integrin-Signaled Induction of Ribonuclease Activity

Molecular pharmacology, 2000-11, Vol.58 (5), p.976-981

2000

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The maintenance of cytochrome P-450 in rat hepatocyte culture: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system

Chemico-Biological Interactions, 1990, Vol.74 (1), p.1-31

Paine, Alan J.

1990

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Review : Heterogeneity of cytochrome P450 and its toxicological significance

Human & Experimental Toxicology, 1995-01, Vol.14 (1), p.1-7

Paine, Alan J.

1995

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Induction of cytochrome P450 3A by metyrapone in human hepatocyte culture

Human & experimental toxicology, 1996-03, Vol.15 (3), p.203-204

1996

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Effect of Vitamin A Deficiency on the Expression of Low Affinity Glucocorticoid Binding Site Activity and Glucocorticoid-Dependent Induction of CYP3A2 in Rat Liver

Biochemical and biophysical research communications, 1997-08, Vol.237 (2), p.211-216

1997

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Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation

Biochemical journal, 1997-12, Vol.328 ( Pt 3) (3), p.937-944

1997

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Of streaming hepatocytes and meandering sinusoids

Human & experimental toxicology, 1994-09, Vol.13 (9), p.604-605

Paine, Alan J

1994

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Environmentally friendly bacteria?: Metabolism of polyhalogenated compounds by a genetically engineered bacterium Wackett LP, Sadowsky M J, Newman L M, Hur H G and Shuying L. Nature 1994, 368 627-629

Human & experimental toxicology, 1994-08, Vol.13 (8), p.574-575

Paine, Alan J

1994

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Rapid Induction of NF- Kappa B Binding during Liver Cell Isolation and Culture: Inhibition by L-NAME Indicates a Role for Nitric Oxide Synthase

Biochemical and biophysical research communications, 1999-04, Vol.257 (1), p.145-148

1999

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Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4

Drug metabolism and disposition, 2000-01, Vol.28 (1), p.96

2000

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Replacing animals in biomedical research

Nature (London), 1978-07, Vol.274 (5668), p.298-298

Paine, Alan J

1978

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Rapid Induction of NF-κB Binding during Liver Cell Isolation and Culture: Inhibition byL-NAMEIndicates a Role for Nitric Oxide Synthase

Biochemical and biophysical research communications, 1999-04, Vol.257 (1), p.145-148

1999

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Evidence that the loss of rat liver cytochrome P450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrix

Biochemical pharmacology, 1992-01, Vol.43 (2), p.237-243

1992

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Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid

Molecular pharmacology, 1996-10, Vol.50 (4), p.856

1996

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Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone

Biochemical journal, 1998-04, Vol.331 ( Pt 1) (1), p.273-281

1998

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Alteration of Transcription Factor mRNAs during the Isolation and Culture of Rat Hepatocytes Suggests the Activation of a Proliferative Mode Underlies Their Dedifferentiation

Biochemical and biophysical research communications, 1993-12, Vol.197 (2), p.599-605

1993

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Induction of the Cytochrome P450 3A Subfamily in Rat Liver Correlates with the Binding of Inducers to a Microsomal Protein

Biochemical and biophysical research communications, 1994-06, Vol.201 (2), p.973-979

1994

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Validity and reliability of in vitro systems in safety evaluation

Environmental Toxicology and Pharmacology, 1996-10, Vol.2 (2), p.207-212

1996

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Induction of rat hepatic glucocorticoid-inducible cytochrome P450 3A by metyrapone

The Journal of steroid biochemistry and molecular biology, 1994-02, Vol.48 (2), p.271-276

1994

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The mechanism of hepatic uptake of a radiolabelled monoclonal antibody

International journal of cancer, 1992-04, Vol.50 (6), p.912-917

1992

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Cytochrome P450 maintenance and diazepam metabolism in cultured rat hepatocytes

Biochemical pharmacology, 1991-08, Vol.42 (6), p.1241-1245

1991

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The effect of hepatocyte culture conditions on cytochrome p-450 linked drug metabolising enzymes

Biochemical pharmacology, 1982-06, Vol.31 (11), p.2141-2144

1982

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RNA interference mediated in human primary cells via recombinant baculoviral vectors

Activation of signalling pathways during hepatocyte isolation: relevance to toxicology in vitro

Developmental changes in the constitutive and inducible expression of cytochrome p450 3a2

Fibronectin-Mediated Hepatocyte Shape Change Reprograms Cytochrome P450 2C11 Gene Expression via an Integrin-Signaled Induction of Ribonuclease Activity

The maintenance of cytochrome P-450 in rat hepatocyte culture: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system

Review : Heterogeneity of cytochrome P450 and its toxicological significance

Induction of cytochrome P450 3A by metyrapone in human hepatocyte culture

Effect of Vitamin A Deficiency on the Expression of Low Affinity Glucocorticoid Binding Site Activity and Glucocorticoid-Dependent Induction of CYP3A2 in Rat Liver

Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation

Of streaming hepatocytes and meandering sinusoids

Environmentally friendly bacteria?: Metabolism of polyhalogenated compounds by a genetically engineered bacterium Wackett LP, Sadowsky M J, Newman L M, Hur H G and Shuying L. Nature 1994, 368 627-629

Rapid Induction of NF- Kappa B Binding during Liver Cell Isolation and Culture: Inhibition by L-NAME Indicates a Role for Nitric Oxide Synthase

Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4

Replacing animals in biomedical research

Rapid Induction of NF-κB Binding during Liver Cell Isolation and Culture: Inhibition byL-NAMEIndicates a Role for Nitric Oxide Synthase

Evidence that the loss of rat liver cytochrome P450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrix

Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid

Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone

Alteration of Transcription Factor mRNAs during the Isolation and Culture of Rat Hepatocytes Suggests the Activation of a Proliferative Mode Underlies Their Dedifferentiation

Induction of the Cytochrome P450 3A Subfamily in Rat Liver Correlates with the Binding of Inducers to a Microsomal Protein

Validity and reliability of in vitro systems in safety evaluation

Induction of rat hepatic glucocorticoid-inducible cytochrome P450 3A by metyrapone

The mechanism of hepatic uptake of a radiolabelled monoclonal antibody

Cytochrome P450 maintenance and diazepam metabolism in cultured rat hepatocytes

The effect of hepatocyte culture conditions on cytochrome p-450 linked drug metabolising enzymes

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