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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

Proceedings of the National Academy of Sciences - PNAS, 2012-06, Vol.109 (24), p.9623-9628

2012

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The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth

Breast cancer research : BCR, 2024-02, Vol.26 (1), p.23-23, Article 23

2024

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Correction: The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth

Breast cancer research : BCR, 2024-03, Vol.26 (1), p.53-53, Article 53

2024

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Identification of novel small molecules that inhibit STAT3-dependent transcription and function

PloS one, 2017-06, Vol.12 (6), p.e0178844

2017

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Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

ACS medicinal chemistry letters, 2013-11, Vol.4 (11), p.1102-1107

2013

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Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein

Biochemistry and cell biology, 2009-12, Vol.87 (6), p.825-833

2009

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Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5605-5609

2011

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Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity

Metabolites, 2023-01, Vol.13 (2), p.151

2023

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Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding

ACS omega, 2020-03, Vol.5 (12), p.6872-6887

2020

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Signal transducer and activator of transcription 3 inhibitors: a patent review

Expert opinion on therapeutic patents, 2011-01, Vol.21 (1), p.65-83

2011

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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Nature communications, 2018, Vol.9 (1), p.250-14, Article 250

2018

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Validating Signal Transducer and Activator of Transcription (STAT) Protein–Inhibitor Interactions Using Biochemical and Cellular Thermal Shift Assays

ACS chemical biology, 2020-07, Vol.15 (7), p.1842-1851

2020

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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

Nature communications, 2015-08, Vol.6 (1), p.7871, Article 7871

2015

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Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity

Journal of medicinal chemistry, 2012-02, Vol.55 (3), p.1047-1055

2012

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Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7190-7200

2013

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An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery

Biomaterials, 2012-02, Vol.33 (5), p.1500-1508

2012

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TSLP as druggable target – a silver-lining for atopic diseases?

Pharmacology & therapeutics (Oxford), 2021-01, Vol.217, p.107648-107648, Article 107648

2021

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Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases

EMBO molecular medicine, 2024-07, Vol.16 (7), p.1630-1656

2024

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Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer

Science signaling, 2014-04, Vol.7 (322), p.ra38

2014

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Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Nature communications, 2019-11, Vol.10 (1), p.1-1, Article 5050

2019

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STAT3 activity is necessary and sufficient for the development of immune‐mediated myocarditis in mice and promotes progression to dilated cardiomyopathy

EMBO molecular medicine, 2013-04, Vol.5 (4), p.572-590

2013

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STAT Protein Thermal Shift Assays to Monitor Protein‐Inhibitor Interactions

Chembiochem : a European journal of chemical biology, 2022-10, Vol.23 (20), p.e202200039-n/a

2022

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NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

Cancer research (Chicago, Ill.), 2016-09, Vol.76 (18), p.5501-5511

2016

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The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101531-101531, Article 101531

2022

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Type II & III inhibitors of tropomyosin receptor kinase (Trk): a 2020-2022 patent update

Expert opinion on therapeutic patents, 2024-04, Vol.34 (4), p.231-244

2024

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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth

Correction: The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth

Identification of novel small molecules that inhibit STAT3-dependent transcription and function

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity

Homology Modeling of Human Uridine-5′-diphosphate-glucuronosyltransferase 1A6 Reveals Insights into Factors Influencing Substrate and Cosubstrate Binding

Signal transducer and activator of transcription 3 inhibitors: a patent review

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Validating Signal Transducer and Activator of Transcription (STAT) Protein–Inhibitor Interactions Using Biochemical and Cellular Thermal Shift Assays

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity

Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma

An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery

TSLP as druggable target – a silver-lining for atopic diseases?

Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases

Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer

Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

STAT3 activity is necessary and sufficient for the development of immune‐mediated myocarditis in mice and promotes progression to dilated cardiomyopathy

STAT Protein Thermal Shift Assays to Monitor Protein‐Inhibitor Interactions

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase

Type II & III inhibitors of tropomyosin receptor kinase (Trk): a 2020-2022 patent update

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