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IUPHAR review: Recent progress in the development of Mu opioid receptor modulators to treat opioid use disorders

Pharmacological research, 2024-01, Vol.199, p.107023-107023, Article 107023

2024

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Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde

Pharmaceutics, 2023-10, Vol.15 (11), p.2547

2023

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Drug discovery efforts toward inhibitors of canonical Wnt/β-catenin signaling pathway in the treatment of cancer: A composition-of-matter review (2010–2020)

Drug discovery today, 2022-04, Vol.27 (4), p.1115-1127

2022

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X-ray crystallography and sickle cell disease drug discovery-a tribute to Donald Abraham

Frontiers in molecular biosciences, 2023-05, Vol.10, p.1136970-1136970

2023

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Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

Pharmaceutics, 2021-07, Vol.13 (8), p.1148

2021

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Uracil-coumarin based hybrid molecules as potent anti-cancer and anti-bacterial agents

Journal of Saudi Chemical Society, 2020-02, Vol.24 (2), p.251-266

2020

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The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications

Medicinal research reviews, 2024-11, Vol.44 (6), p.2707-2729

2024

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Novel PROTAC probes targeting FOSL1 degradation to eliminate head and neck squamous cell carcinoma cancer stem cells

Bioorganic chemistry, 2024-10, Vol.151, p.107613, Article 107613

2024

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Systematic Structure–Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.9552-9574

2024

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Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

Expert opinion on therapeutic patents, 2022-02, Vol.32 (2), p.115-130

2022

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NCP, a Dual Kappa and Mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties

The Journal of pharmacology and experimental therapeutics, 2024-04, Vol.389 (1), p.106-117

2024

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Structure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT2B receptor antagonist scaffold

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127511-127511, Article 127511

2020

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Structural Alterations of the “Address” Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.577-595

2023

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A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond

Cold Spring Harbor perspectives in biology, 2020-04, Vol.12 (4), p.a034116

2020

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Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression

Journal of medicinal chemistry, 2024-01, Vol.67 (1), p.603-619

2024

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Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists

Journal of medicinal chemistry, 2022-03, Vol.65 (6), p.5095-5112

2022

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Exploration of Structure–Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14724-14739

2020

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Exploration of naphthoquinone analogs in targeting the TCF-DNA interaction to inhibit the Wnt/β-catenin signaling pathway

Bioorganic chemistry, 2022-07, Vol.124, p.105812-105812, Article 105812

2022

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Development of structure-based pharmacophore to target the β-catenin-TCF protein–protein interaction

Medicinal chemistry research, 2021-02, Vol.30 (2), p.429-439

2021

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Understanding the role of glucose regulated protein 170 (GRP170) as a nucleotide exchange factor through molecular simulations

Journal of molecular graphics & modelling, 2018-10, Vol.85, p.160-170

2018

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VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

Scientific reports, 2020-11, Vol.10 (1), p.20277-20277, Article 20277

2020

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Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5‑HMF for the Treatment of Sickle Cell Disease

Molecular pharmaceutics, 2017-10, Vol.14 (10), p.3499-3511

2017

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Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

Acta crystallographica. Section D, Biological crystallography., 2018-10, Vol.74 (10), p.956-964

2018

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Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease

Bioorganic & medicinal chemistry, 2018-05, Vol.26 (9), p.2530-2538

2018

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Novel bivalent ligands carrying potential antinociceptive effects by targeting putative mu opioid receptor and chemokine receptor CXCR4 heterodimers

Bioorganic chemistry, 2022-03, Vol.120, p.105641-105641, Article 105641

2022

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IUPHAR review: Recent progress in the development of Mu opioid receptor modulators to treat opioid use disorders

Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde

Drug discovery efforts toward inhibitors of canonical Wnt/β-catenin signaling pathway in the treatment of cancer: A composition-of-matter review (2010–2020)

X-ray crystallography and sickle cell disease drug discovery-a tribute to Donald Abraham

Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

Uracil-coumarin based hybrid molecules as potent anti-cancer and anti-bacterial agents

The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications

Novel PROTAC probes targeting FOSL1 degradation to eliminate head and neck squamous cell carcinoma cancer stem cells

Systematic Structure–Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments

Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property

NCP, a Dual Kappa and Mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties

Structure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT2B receptor antagonist scaffold

Structural Alterations of the “Address” Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity

A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond

Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression

Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists

Exploration of Structure–Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Exploration of naphthoquinone analogs in targeting the TCF-DNA interaction to inhibit the Wnt/β-catenin signaling pathway

Development of structure-based pharmacophore to target the β-catenin-TCF protein–protein interaction

Understanding the role of glucose regulated protein 170 (GRP170) as a nucleotide exchange factor through molecular simulations

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5‑HMF for the Treatment of Sickle Cell Disease

Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation

Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease

Novel bivalent ligands carrying potential antinociceptive effects by targeting putative mu opioid receptor and chemokine receptor CXCR4 heterodimers

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