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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

Biochemical journal, 2011-06, Vol.436 (2), p.331-339

2011

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Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice

Cancer research (Chicago, Ill.), 2018-10, Vol.78 (19), p.5644-5655

2018

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Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.15787-15798

2021

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Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression

Molecular cancer therapeutics, 2015-10, Vol.14 (10), p.2167-2174

2015

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Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1)

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4438-4441

2008

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Antagonists of CCR4 as immunomodulatory agents

Current topics in medicinal chemistry, 2006-07, Vol.6 (13), p.1335-1344

2006

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Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (11), p.2924-2927

2009

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9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors

Bioorganic & medicinal chemistry letters, 2015-07, Vol.25 (14), p.2809-2812

2015

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Benzo[ d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5063-5066

2009

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Core exploration in optimization of chemokine receptor CCR4 antagonists

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.679-682

2007

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Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5‑d]pyrrolo[2,3‑b]pyridine Inhibitors

ACS medicinal chemistry letters, 2015-08, Vol.6 (8), p.845-849

2015

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Identification of chemokine receptor CCR4 antagonist

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2669-2672

2005

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Improved conditions for converting sterically hindered amides to 1,5-disubstituted tetrazoles

Tetrahedron letters, 2010-03, Vol.51 (10), p.1404-1406

2010

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Pyrrolo[1,2- f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (5), p.1425-1428

2011

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Synthesis of chiral α- substituted β-hydroxy acid derivatives on solid support

Tetrahedron letters, 1997-12, Vol.38 (51), p.8777-8780

1997

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Optimization of CCR4 antagonists: Side-chain exploration

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (1), p.204-207

2006

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Identification of a potent and rapidly reversible inhibitor of the 20S-proteasome

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (18), p.4701-4704

2004

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Abstract 4004: Targeting drug-resistant acute myeloid leukemia (AML) cells using novel casein kinase II (CK2) inhibitor

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.4004-4004

2023

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Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists

Bioorganic & medicinal chemistry letters, 2021-03, Vol.35, p.127778-127778, Article 127778

2021

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Diaminopyrimidine and diaminopyridine 5-HT7 ligands

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (16), p.4249-4252

2004

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Abstract A68: A casein kinase 2 inhibitor disorders myeloid cell differentiation by blocking CCAAT/enhancer-binding protein-alpha signaling pathway in tumor microenvironment

Cancer immunology research, 2020-04, Vol.8 (4_Supplement), p.A68-A68

2020

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Solid phase synthesis of unsymmetrical secondary amines—Application to the synthesis of arylethanolamines and arylpropanolamines

Tetrahedron letters, 1998-02, Vol.39 (9), p.935-938

1998

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Abstract 5395: Anti-tumor activity of BMS-595, a novel CK2 kinase inhibitor

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5395-5395

2015

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Abstract 5417: The identification of BMS-595, an orally active imidazo[1,2-b]pyridazine CK2 inhibitor with in vivo anti-tumor activity

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5417-5417

2015

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice

Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression

Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1)

Antagonists of CCR4 as immunomodulatory agents

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)

9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors

Benzo[ d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms

Core exploration in optimization of chemokine receptor CCR4 antagonists

Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5‑d]pyrrolo[2,3‑b]pyridine Inhibitors

Identification of chemokine receptor CCR4 antagonist

Improved conditions for converting sterically hindered amides to 1,5-disubstituted tetrazoles

Pyrrolo[1,2- f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3

Synthesis of chiral α- substituted β-hydroxy acid derivatives on solid support

Optimization of CCR4 antagonists: Side-chain exploration

Identification of a potent and rapidly reversible inhibitor of the 20S-proteasome

Abstract 4004: Targeting drug-resistant acute myeloid leukemia (AML) cells using novel casein kinase II (CK2) inhibitor

Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists

Diaminopyrimidine and diaminopyridine 5-HT7 ligands

Abstract A68: A casein kinase 2 inhibitor disorders myeloid cell differentiation by blocking CCAAT/enhancer-binding protein-alpha signaling pathway in tumor microenvironment

Solid phase synthesis of unsymmetrical secondary amines—Application to the synthesis of arylethanolamines and arylpropanolamines

Abstract 5395: Anti-tumor activity of BMS-595, a novel CK2 kinase inhibitor

Abstract 5417: The identification of BMS-595, an orally active imidazo[1,2-b]pyridazine CK2 inhibitor with in vivo anti-tumor activity

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