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Exploring new targets and chemical space with affinity selection-mass spectrometry

Nature reviews. Chemistry, 2021-01, Vol.5 (1), p.62-71

2021

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A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

PloS one, 2018-12, Vol.13 (12), p.e0208979-e0208979

2018

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Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues Which Reversibly Depolymerize Microtubules

Molecules (Basel, Switzerland), 2021-01, Vol.26 (3), p.706

2021

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A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity

Cell death & disease, 2024-05, Vol.15 (5), p.311-311, Article 311

2024

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Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations

Blood, 2010-09, Vol.116 (9), p.1604-1612

2010

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Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines

PloS one, 2013-09, Vol.8 (9), p.e71935-e71935

2013

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Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Cancer research (Chicago, Ill.), 2012-09, Vol.72 (17), p.4429-4439

2012

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Preclinical Evaluation of a Novel Small Molecule Inhibitor of LIM Kinases (LIMK) CEL_Amide in Philadelphia-Chromosome Positive ( BCR::ABL+ ) Acute Lymphoblastic Leukemia (ALL)

Journal of clinical medicine, 2022-11, Vol.11 (22), p.6761

2022

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Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches

International journal of molecular sciences, 2018-10, Vol.19 (10), p.3085

2018

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New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

The FASEB journal, 2010-09, Vol.24 (9), p.3171-3185

2010

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Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

Cancers, 2020-08, Vol.12 (8), p.2196

2020

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Functional Analysis of Protein Kinase CK2 of the Human Malaria Parasite Plasmodium falciparum

Eukaryotic Cell, 2009-03, Vol.8 (3), p.388-397

2009

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Antitumoral activity of allosteric inhibitors of protein kinase CK2

Oncotarget, 2011-12, Vol.2 (12), p.997-1010

2011

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Affinity selection mass spectrometry speeding drug discovery

Drug discovery today, 2023-11, Vol.28 (11), p.103760-103760, Article 103760

2023

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Novel synthetic pharmacophores inducing a stabilization of cellular microtubules

Current cancer drug targets, 2015-01, Vol.15 (1), p.2-13

2015

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LIM kinases: cofilin and beyond

Oncotarget, 2017-06, Vol.8 (25), p.41749-41763

2017

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Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors

Journal of medicinal chemistry, 2022-11, Vol.65 (22), p.15300-15311

2022

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Expanding the chemical diversity of CK2 inhibitors

Molecular and cellular biochemistry, 2008-09, Vol.316 (1-2), p.71-85

2008

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Synergy of FLT3 inhibitors and the small molecule inhibitor of LIM kinase1/2 CEL_Amide in FLT3-ITD mutated Acute Myeloblastic Leukemia (AML) cells

Leukemia research, 2021-01, Vol.100, p.106490, Article 106490

2021

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Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues Which Reversibly Depolymerize Microtubules

Molecules (Basel, Switzerland), 2021-01, Vol.26 (3)

2021

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New Protein Kinase CK2 Inhibitors: Jumping out of the Catalytic Box

Chemistry & biology, 2009-02, Vol.16 (2), p.112-120

2009

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Abstract 341: Synergy of FLT3 inhibitors and a small molecule inhibitor of LIM kinase1/2 in FLT3-ITD positive acute myeloblastic leukemia (AML)

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.341-341

2019

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Sulfamoylated Estradiol Analogs Targeting the Actin and Microtubule Cytoskeletons Demonstrate Anti-Cancer Properties In Vitro and In Ovo

Cancers, 2024-08, Vol.16 (17), p.2941

2024

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LIM Kinases: cofilin and beyond

Oncotarget, 2017

2017

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Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

Scientific reports, 2019-11, Vol.9 (1), p.15893-16, Article 15893

2019

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Exploring new targets and chemical space with affinity selection-mass spectrometry

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues Which Reversibly Depolymerize Microtubules

A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity

Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations

Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines

Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Preclinical Evaluation of a Novel Small Molecule Inhibitor of LIM Kinases (LIMK) CEL_Amide in Philadelphia-Chromosome Positive ( BCR::ABL+ ) Acute Lymphoblastic Leukemia (ALL)

Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

Functional Analysis of Protein Kinase CK2 of the Human Malaria Parasite Plasmodium falciparum

Antitumoral activity of allosteric inhibitors of protein kinase CK2

Affinity selection mass spectrometry speeding drug discovery

Novel synthetic pharmacophores inducing a stabilization of cellular microtubules

LIM kinases: cofilin and beyond

Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors

Expanding the chemical diversity of CK2 inhibitors

Synergy of FLT3 inhibitors and the small molecule inhibitor of LIM kinase1/2 CEL_Amide in FLT3-ITD mutated Acute Myeloblastic Leukemia (AML) cells

Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues Which Reversibly Depolymerize Microtubules

New Protein Kinase CK2 Inhibitors: Jumping out of the Catalytic Box

Abstract 341: Synergy of FLT3 inhibitors and a small molecule inhibitor of LIM kinase1/2 in FLT3-ITD positive acute myeloblastic leukemia (AML)

Sulfamoylated Estradiol Analogs Targeting the Actin and Microtubule Cytoskeletons Demonstrate Anti-Cancer Properties In Vitro and In Ovo

LIM Kinases: cofilin and beyond

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

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