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Inhibitors of the heat shock response: Biology and pharmacology

FEBS letters, 2007-07, Vol.581 (19), p.3758-3769

2007

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Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

Cancer cell, 2008-09, Vol.14 (3), p.250-262

2008

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Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors

Endocrine-related cancer, 2006-12, Vol.13 (Supplement_1), p.S125-S135

2006

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Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells

Cancer research (Chicago, Ill.), 2016-05, Vol.76 (9), p.2731-2742

2016

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Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

Cell cycle (Georgetown, Tex.), 2010-04, Vol.9 (8), p.1542-1550

2010

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Death by chaperone: HSP90, HSP70 or both?

Cell cycle (Georgetown, Tex.), 2009-02, Vol.8 (4), p.518-526

2009

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Dissociating movement from movement timing in the rat primary motor cortex

The Journal of neuroscience, 2014-11, Vol.34 (47), p.15576-15586

2014

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Neural population partitioning and a concurrent brain-machine interface for sequential motor function

Nature neuroscience, 2012-12, Vol.15 (12), p.1715-1722

2012

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A real-time brain-machine interface combining motor target and trajectory intent using an optimal feedback control design

PloS one, 2013-04, Vol.8 (4), p.e59049-e59049

2013

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Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer

Nature chemical biology, 2007-08, Vol.3 (8), p.455-457

2007

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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Journal of medicinal chemistry, 2017-01, Vol.60 (1), p.180-201

2017

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Drugging the heat shock factor 1 pathway: Exploitation of the critical cancer cell dependence on the guardian of the proteome

Cell cycle (Georgetown, Tex.), 2009-12, Vol.8 (23), p.3806-3808

2009

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Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

Molecular cancer therapeutics, 2007-04, Vol.6 (4), p.1198-1211

2007

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Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX

Oncotarget, 2013-11, Vol.4 (11), p.1963-1975

2013

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In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors

Cancer research (Chicago, Ill.), 2007-03, Vol.67 (5), p.2206-2216

2007

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The routes so far trod and where we may go next to inhibit protein folding by the molecular chaperone heat shock protein 90

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2009-06, Vol.153 (2), p.S159

Powers, Marissa

2009

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HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

Journal of medicinal chemistry, 2023-04, Vol.66 (8), p.5907-5936

2023

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Abstract 4772: Addiction to chaperones: Investigating the role of HSP70 isoforms in cancer

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4772-4772

2016

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Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

Oncogene, 2015-01, Vol.34 (1), p.15-26

2015

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Abstract 524: Using acquired resistance to explore the mechanism of action of the integrated stress response/GCN2 activator NXP800 - A new developmental agent for platinum-resistant ARID1A mutant ovarian cancer

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.524-524

2024

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Abstract 2058: Compound library screening to identify modulators of alternative splicing in non-small cell lung cancer (NSCLC)

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.2058-2058

2024

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Abstract A016: NXP800, a novel, small molecule GCN2 kinase activator, demonstrates potent single-agent activity in ARID1A and ARID1B-deficient endometrial cancer xenograft models

Clinical cancer research, 2024-03, Vol.30 (5_Supplement), p.A016-A016

2024

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Abstract 2998: Molecular and cellular effects of individual and combinatorial silencing of HSP90 paralogs

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2998-2998

2016

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Abstract 2976: Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.2976-2976

2018

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Abstract 6441: Discovery of ARID1A loss as a patient biomarker for NXP800 - A developmental activator of the integrated stress response (ISR) and inhibitor of the HSF1 pathway in ovarian cancer

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.6441-6441

2024

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Inhibitors of the heat shock response: Biology and pharmacology

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors

Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells

Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

Death by chaperone: HSP90, HSP70 or both?

Dissociating movement from movement timing in the rat primary motor cortex

Neural population partitioning and a concurrent brain-machine interface for sequential motor function

A real-time brain-machine interface combining motor target and trajectory intent using an optimal feedback control design

Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Drugging the heat shock factor 1 pathway: Exploitation of the critical cancer cell dependence on the guardian of the proteome

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX

In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors

The routes so far trod and where we may go next to inhibit protein folding by the molecular chaperone heat shock protein 90

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

Abstract 4772: Addiction to chaperones: Investigating the role of HSP70 isoforms in cancer

Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

Abstract 524: Using acquired resistance to explore the mechanism of action of the integrated stress response/GCN2 activator NXP800 - A new developmental agent for platinum-resistant ARID1A mutant ovarian cancer

Abstract 2058: Compound library screening to identify modulators of alternative splicing in non-small cell lung cancer (NSCLC)

Abstract A016: NXP800, a novel, small molecule GCN2 kinase activator, demonstrates potent single-agent activity in ARID1A and ARID1B-deficient endometrial cancer xenograft models

Abstract 2998: Molecular and cellular effects of individual and combinatorial silencing of HSP90 paralogs

Abstract 2976: Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin

Abstract 6441: Discovery of ARID1A loss as a patient biomarker for NXP800 - A developmental activator of the integrated stress response (ISR) and inhibitor of the HSF1 pathway in ovarian cancer

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