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Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid

European journal of medicinal chemistry, 2018-04, Vol.150, p.930-945

2018

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Dansyl linked solid phase resins as an educational tool to teach the concepts of high throughput screening and prodrugs

British Journal of Pharmacy, 2023-05, Vol.8 (1), p.1-16

2023

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Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

Scientific reports, 2016-09, Vol.6 (1), p.33026, Article 33026

2016

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Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors

Molecules (Basel, Switzerland), 2021-09, Vol.26 (19), p.5770

2021

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The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis

Frontiers in physiology, 2022-05, Vol.13, p.897105-897105

2022

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Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer

Scientific reports, 2021-09, Vol.11 (1), p.18930-18930, Article 18930

2021

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Editorial: Chemical Biology Tools for Peptide and Protein Research

Frontiers in chemistry, 2022-02, Vol.10, p.861699-861699

2022

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Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies

Biomedicines, 2021-03, Vol.9 (3), p.290

2021

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Encapsulation and Delivery of Mitoxantrone Using Zirconium-Based Metal–Organic Frameworks (MOFs) and Their Cytotoxic Potential in Breast Cancer Cells

Applied sciences, 2024-02, Vol.14 (5), p.1902

2024

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Quantitative analysis of cytochrome P450 isoforms in human liver microsomes by the combination of proteomics and chemical probe-based assay

Proteomics (Weinheim), 2014-08, Vol.14 (16), p.1943-1951

2014

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Aldehyde Dehydrogenases and Prostate Cancer: Shedding Light on Isoform Distribution to Reveal Druggable Target

Biomedicines, 2020-12, Vol.8 (12), p.569

2020

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Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products

Current topics in medicinal chemistry, 2009-11, Vol.9 (16), p.1494-1524

2009

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Current challenges and opportunities in treating hypoxic prostate tumors

Journal of cancer metastasis and treatment, 2018-03, Vol.4 (3), p.11

2018

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Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention

Journal of cancer metastasis and treatment, 2017-12, Vol.3 (12), p.328

2017

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Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development?

Drug discovery today, 2014-12, Vol.19 (12), p.1953-1963

2014

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DNA mismatch repair deficiency, resistance to cancer chemotherapy and the development of hypersensitive agents

Current topics in medicinal chemistry, 2005-10, Vol.5 (12), p.1133-1149

2005

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How can the potential of the duocarmycins be unlocked for cancer therapy?

Drug discovery today, 2021-02, Vol.26 (2), p.577-584

2021

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Abstract 2020: Investigation of CYP450 enzymes as therapeutic targets in rhabdomyosarcoma

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2020-2020

2022

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Structural Investigations of Prodrug Activation by Human Cytochrome P450 Enzymes

The FASEB journal, 2019-04, Vol.33 (S1), p.673.2-673.2

2019

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Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

Drug metabolism and disposition, 2021-10, Vol.50 (1)

2021

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Deep Transfer Learning-Based Approach for Glucose Transporter-1 (GLUT1) Expression Assessment

Journal of digital imaging, 2023-12, Vol.36 (6), p.2367-2381

2023

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The Capacity of Drug-Metabolising Enzymes in Modulating the Therapeutic Efficacy of Drugs to Treat Rhabdomyosarcoma

Cancers, 2024-02, Vol.16 (5), p.1012

2024

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Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

Drug metabolism and disposition, 2022-01, Vol.50 (1), p.49-57

2022

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Abstract 4545: Quantitative profiling of Cytochrome P450 2S1 in colorectal cancer by PRM assay

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.4545-4545

2019

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New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold

European journal of medicinal chemistry, 2022-07, Vol.237, p.114366-114366, Article 114366

2022

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Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid

Dansyl linked solid phase resins as an educational tool to teach the concepts of high throughput screening and prodrugs

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors

The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis

Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer

Editorial: Chemical Biology Tools for Peptide and Protein Research

Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies

Encapsulation and Delivery of Mitoxantrone Using Zirconium-Based Metal–Organic Frameworks (MOFs) and Their Cytotoxic Potential in Breast Cancer Cells

Quantitative analysis of cytochrome P450 isoforms in human liver microsomes by the combination of proteomics and chemical probe-based assay

Aldehyde Dehydrogenases and Prostate Cancer: Shedding Light on Isoform Distribution to Reveal Druggable Target

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products

Current challenges and opportunities in treating hypoxic prostate tumors

Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention

Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development?

DNA mismatch repair deficiency, resistance to cancer chemotherapy and the development of hypersensitive agents

How can the potential of the duocarmycins be unlocked for cancer therapy?

Abstract 2020: Investigation of CYP450 enzymes as therapeutic targets in rhabdomyosarcoma

Structural Investigations of Prodrug Activation by Human Cytochrome P450 Enzymes

Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

Deep Transfer Learning-Based Approach for Glucose Transporter-1 (GLUT1) Expression Assessment

The Capacity of Drug-Metabolising Enzymes in Modulating the Therapeutic Efficacy of Drugs to Treat Rhabdomyosarcoma

Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

Abstract 4545: Quantitative profiling of Cytochrome P450 2S1 in colorectal cancer by PRM assay

New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold

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