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Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective

The AAPS journal, 2008-12, Vol.10 (4), Article 537

2008

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Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.660

2007

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In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation

Molecular pharmacology, 2006-10, Vol.70 (4), p.1212-1219

2006

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Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

The Journal of pharmacology and experimental therapeutics, 2007-10, Vol.323 (1), p.346

2007

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Variable modulation of opioid brain uptake by P-glycoprotein in mice

Biochemical pharmacology, 2004-01, Vol.67 (2), p.269-276

2004

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Assessment of Blood-Brain Barrier Permeability Using the In Situ Mouse Brain Perfusion Technique

Pharmaceutical research, 2009-07, Vol.26 (7), p.1657-1664

2009

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Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

Pharmaceutical research, 2008-08, Vol.25 (8), p.1851-1860

2008

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Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier

Drug metabolism and disposition, 2009-06, Vol.37 (6), p.1251

2009

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Relationship between drug/metabolite exposure and impairment of excretory transport function

Drug metabolism and disposition, 2009-02, Vol.37 (2), p.386

2009

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Functional evidence for P-glycoprotein at the nose-brain barrier

Pharmaceutical research, 2005-01, Vol.22 (1), p.86-93

2005

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Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation

Methods in molecular biology (Clifton, N.J.), 2010-01, Vol.596, p.359

2010

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Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin

The Journal of pharmacology and experimental therapeutics, 2003-08, Vol.306 (2), p.556

2003

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Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein Modulation

Pharmacotherapy, 2001-07, Vol.21 (7), p.778-796

2001

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Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver

The Journal of pharmacology and experimental therapeutics, 2003-02, Vol.304 (2), p.801

2003

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Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.529

2009

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Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective

The AAPS journal, 2008-12, Vol.10 (4), p.537-551

2008

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Preparing for a Renaissance in pharmacy education: the need, opportunity, and capacity for change

American journal of pharmaceutical education, 2008-04, Vol.72 (2), p.42-42

2008

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Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues

Drug metabolism and disposition, 2004-09, Vol.32 (9), p.1008

2004

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Nasal Drug Administration: Potential for Targeted Central Nervous System Delivery

Journal of pharmaceutical sciences, 2005-06, Vol.94 (6), p.1187-1195

2005

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Morphine antinociception is enhanced in mdr1a gene-deficient mice

Pharmaceutical research, 2000-06, Vol.17 (6), p.749-753

2000

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Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver

Drug metabolism and disposition, 2009-09, Vol.37 (9), p.1916

2009

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Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment

Drug metabolism and disposition, 2002-09, Vol.30 (9), p.962

2002

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Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.287

2005

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Pharmacokinetics and pharmacodynamics of alfentanil in P-glycoprotein-competent and P-glycoprotein-deficient mice: P-glycoprotein efflux alters alfentanil brain disposition and antinociception

Drug metabolism and disposition, 2007-03, Vol.35 (3), p.455

2007

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Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: A quantitative analysis of regional drug exposure in the brain

Biochemical pharmacology, 2009-10, Vol.78 (8), p.1052-1059

2009

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Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective

Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation

Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data

Variable modulation of opioid brain uptake by P-glycoprotein in mice

Assessment of Blood-Brain Barrier Permeability Using the In Situ Mouse Brain Perfusion Technique

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier

Relationship between drug/metabolite exposure and impairment of excretory transport function

Functional evidence for P-glycoprotein at the nose-brain barrier

Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation

Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin

Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein Modulation

Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver

Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration

Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective

Preparing for a Renaissance in pharmacy education: the need, opportunity, and capacity for change

Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues

Nasal Drug Administration: Potential for Targeted Central Nervous System Delivery

Morphine antinociception is enhanced in mdr1a gene-deficient mice

Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver

Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment

Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin

Pharmacokinetics and pharmacodynamics of alfentanil in P-glycoprotein-competent and P-glycoprotein-deficient mice: P-glycoprotein efflux alters alfentanil brain disposition and antinociception

Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: A quantitative analysis of regional drug exposure in the brain

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