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Role of lymphatic vasculature in regional and distant metastases

Microvascular research, 2014-09, Vol.95, p.46-52

2014

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Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism

The Journal of immunology (1950), 2009-08, Vol.183 (3), p.1767-1779

2009

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Activation of NF-κB by the Latent vFLIP Gene of Kaposi's Sarcoma-Associated Herpesvirus Is Required for the Spindle Shape of Virus-Infected Endothelial Cells and Contributes to Their Proinflammatory Phenotype

Journal of Virology, 2006-07, Vol.80 (14), p.7179-7185

2006

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Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first‐in‐human phase I study

Clinical and translational science, 2024-04, Vol.17 (4), p.e13762-n/a

2024

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Molecular Characterization of Lymphatic Endothelial Cells

Proceedings of the National Academy of Sciences - PNAS, 2002-12, Vol.99 (25), p.16069-16074

2002

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Vascular Endothelial Growth Factor-C Induces Lymphangitic Carcinomatosis, an Extremely Aggressive Form of Lung Metastases

Cancer research (Chicago, Ill.), 2010-03, Vol.70 (5), p.1814-1824

2010

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Role of lymphatic vasculature in regional and distant metastasis

Microvascular research, 2014-07, Vol.95, p.46-52

2014

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Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses

The Journal of experimental medicine, 2013-07, Vol.210 (8), p.1509-1528

2013

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Abstract LB-333: Lymphatic endothelium increases antioxidant capacity of triple-negative breast cancer cells and protects from cell death

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.LB-333-LB-333

2017

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Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2

Cancer research (Chicago, Ill.), 2006-03, Vol.66 (5), p.2650-2657

2006

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Pharmacokinetics of Mibavademab in Healthy Participants: Results from a Randomized, Phase 1, Two-Part, First-in-Human Study

Journal of clinical lipidology, 2023-07, Vol.17 (4), p.e58

2023

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Abstract 443: Lymphatic endothelium protects breast cancer cells from death by inducing metabolic adaptations

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.443-443

2017

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FRI057 Drug Concentrations And Dosing Considerations For Mibavademab, A Novel Leptin Receptor Agonist, In Individuals With Generalized Lipodystrophy

Journal of the Endocrine Society, 2023-10, Vol.7 (Supplement_1)

2023

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Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

The Journal of clinical investigation, 2007-11, Vol.117 (11), p.3369-3382

2007

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Abstract 1931: Mathematical modeling predicts exponential growth kinetics for metastases in the lymphatic vessels in the absence of vascularization

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1931-1931

2015

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FRI059 Long-term Follow-up On Partial Lipodystrophy Treated With Leptin Receptor Agonist Mibavademab(REGN4461)

Journal of the Endocrine Society, 2023-10, Vol.7 (Supplement_1)

2023

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FRI069 Treatment With Mibavademab, A Novel Leptin Receptor Agonist, Is Associated With Improvement In Weight And Associated Comorbidities In Congenital Leptin Deficiency

Journal of the Endocrine Society, 2023-10, Vol.7 (Supplement_1)

2023

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FRI058 Treatment With Mibavademab, A Novel Leptin Receptor Agonist, Is Associated With Improvement In Metabolic Parameters In Individuals With Generalized Lipodystrophy

Journal of the Endocrine Society, 2023-10, Vol.7 (Supplement_1)

2023

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Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance

Oncogene, 2015-02, Vol.34 (7), p.857-867

2015

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Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac–/ICAM-1-dependent mechanism

The Journal of immunology (1950), 2009-07, Vol.183 (3), p.1767-1779

2009

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Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype

Journal of virology, 2006-07, Vol.80 (14), p.7179-7185

2006

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Role of lymphatic vasculature in regional and distant metastases

Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism

Activation of NF-κB by the Latent vFLIP Gene of Kaposi's Sarcoma-Associated Herpesvirus Is Required for the Spindle Shape of Virus-Infected Endothelial Cells and Contributes to Their Proinflammatory Phenotype

Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first‐in‐human phase I study

Molecular Characterization of Lymphatic Endothelial Cells

Vascular Endothelial Growth Factor-C Induces Lymphangitic Carcinomatosis, an Extremely Aggressive Form of Lung Metastases

Role of lymphatic vasculature in regional and distant metastasis

Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses

Abstract LB-333: Lymphatic endothelium increases antioxidant capacity of triple-negative breast cancer cells and protects from cell death

Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2

Pharmacokinetics of Mibavademab in Healthy Participants: Results from a Randomized, Phase 1, Two-Part, First-in-Human Study

Abstract 443: Lymphatic endothelium protects breast cancer cells from death by inducing metabolic adaptations

Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency

FRI057 Drug Concentrations And Dosing Considerations For Mibavademab, A Novel Leptin Receptor Agonist, In Individuals With Generalized Lipodystrophy

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

Abstract 1931: Mathematical modeling predicts exponential growth kinetics for metastases in the lymphatic vessels in the absence of vascularization

FRI059 Long-term Follow-up On Partial Lipodystrophy Treated With Leptin Receptor Agonist Mibavademab(REGN4461)

FRI069 Treatment With Mibavademab, A Novel Leptin Receptor Agonist, Is Associated With Improvement In Weight And Associated Comorbidities In Congenital Leptin Deficiency

FRI058 Treatment With Mibavademab, A Novel Leptin Receptor Agonist, Is Associated With Improvement In Metabolic Parameters In Individuals With Generalized Lipodystrophy

Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance

Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac–/ICAM-1-dependent mechanism

Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype

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