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Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2

European journal of clinical pharmacology, 2012-06, Vol.68 (6), p.951-960

2012

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Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction

British journal of clinical pharmacology, 2008-05, Vol.65 (5), p.680-692

2008

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Drug metabolites as cytochrome p450 inhibitors: a retrospective analysis and proposed algorithm for evaluation of the pharmacokinetic interaction potential of metabolites in drug discovery and development

Drug metabolism and disposition, 2013-12, Vol.41 (12), p.2047

2013

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Pharmacokinetics, pharmacodynamics, and safety of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, in healthy subjects when administered in co‐mixture with recombinant human hyaluronidase: A phase 1 randomized trial

Health science reports, 2018-09, Vol.1 (9), p.e61-n/a

2018

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Novel, Selective Vitamin D Analog Suppresses Parathyroid Hormone in Uremic Animals and Postmenopausal Women

American journal of nephrology, 2014-01, Vol.39 (6), p.476-483

2014

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Development of a Physiologically Based Pharmacokinetic Model for Estradiol in Rats and Humans: A Biologically Motivated Quantitative Framework for Evaluating Responses to Estradiol and Other Endocrine-Active Compounds

Toxicological sciences, 2002-09, Vol.69 (1), p.60-78

2002

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The sulfonylurea glipizide does not inhibit ischemic preconditioning in anesthetized rabbits

Cardiovascular drugs and therapy, 2005-10, Vol.19 (5), p.337-346

2005

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MODE-OF-ACTION–BASED DOSIMETERS FOR INTERSPECIES EXTRAPOLATION OF VINYL ACETATE INHALATION RISK

Inhalation toxicology, 2001-05, Vol.13 (5), p.377-396

2001

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A physiologically based pharmacokinetic model for nicotine disposition in the Sprague-Dawley rat

Toxicology and applied pharmacology, 1992-10, Vol.116 (2), p.177-188

1992

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ROLE OF PROLACTIN IN CHLORO-S-TRIAZINE RAT MAMMARY TUMORIGENESIS

Drug and chemical toxicology (New York, N.Y. 1978), 2000-01, Vol.23 (4), p.575-601

2000

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MODE-OF-ACTION?BASED DOSIMETERS FOR INTERSPECIES EXTRAPOLATION OF VINYL ACETATE INHALATION RISK

Inhalation toxicology, 2001-05, Vol.13 (5), p.377-396

2001

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Comparison of random and serial sections in assessment of ovarian toxicity

Reproductive toxicology (Elmsford, N.Y.), 1991, Vol.5 (4), p.379-383

1991

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A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity

Toxicological sciences, 1999-09, Vol.51 (1), p.19-35

1999

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The nitrosation of nicotine: a kinetic study

Chemical research in toxicology, 1991-09, Vol.4 (5), p.513-516

1991

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Physiologically Based Modeling of Vinyl Acetate Uptake, Metabolism, and Intracellular pH Changes in the Rat Nasal Cavity

Toxicology and applied pharmacology, 1997-02, Vol.142 (2), p.386-400

1997

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Phosphoramide mustard is responsible for the ovarian toxicity of cyclophosphamide

Toxicology and applied pharmacology, 1991-03, Vol.107 (3), p.472-481

1991

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Reproductive toxicity of cyclophosphamide in the C57BL/6N mouse: 1. Effects on ovarian structure and function

Reproductive toxicology (Elmsford, N.Y.), 1992-01, Vol.6 (5), p.411-421

1992

Volltextzugriff (PDF)

Analysis of Vinyl Acetate Metabolism in Rat and Human Nasal Tissues by an in Vitro Gas Uptake Technique

Toxicological sciences, 1998-12, Vol.46 (2), p.235-246

1998

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Reproductive Toxicity: Male and Female Reproductive Systems as Targets for Chemical Injury

The Medical clinics of North America, 1990-03, Vol.74 (2), p.391-411

1990

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The Effect of Smoking on Oogenesis, Fertilization, and Implantation

Seminars in reproductive medicine, 1989-11, Vol.7 (4), p.291-304

1989

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The effect of benzo(a)pyrene on murine ovarian and corpora lutea volumes

American journal of obstetrics and gynecology, 1992-05, Vol.166 (5), p.1535-1541

1992

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Reproductive toxicity of cyclophosphamide in the C57BL/6N mouse: 2. Effects on uterine structure and function

Reproductive toxicology (Elmsford, N.Y.), 1992-01, Vol.6 (5), p.423-429

1992

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Dosimetry of Vinyl Acetate in The Nasal Passages of Rats: Comparison of in Vitro and in Vivo Methods of Quantifying Metabolism

Inhalation toxicology, 1994-12, Vol.6 (sup1), p.409-412

1994

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Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction

Drug metabolism and disposition, 2009-08, Vol.37 (8), p.1658

2009

Volltextzugriff (PDF)

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Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2

Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction

Drug metabolites as cytochrome p450 inhibitors: a retrospective analysis and proposed algorithm for evaluation of the pharmacokinetic interaction potential of metabolites in drug discovery and development

Pharmacokinetics, pharmacodynamics, and safety of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, in healthy subjects when administered in co‐mixture with recombinant human hyaluronidase: A phase 1 randomized trial

Novel, Selective Vitamin D Analog Suppresses Parathyroid Hormone in Uremic Animals and Postmenopausal Women

Development of a Physiologically Based Pharmacokinetic Model for Estradiol in Rats and Humans: A Biologically Motivated Quantitative Framework for Evaluating Responses to Estradiol and Other Endocrine-Active Compounds

The sulfonylurea glipizide does not inhibit ischemic preconditioning in anesthetized rabbits

MODE-OF-ACTION–BASED DOSIMETERS FOR INTERSPECIES EXTRAPOLATION OF VINYL ACETATE INHALATION RISK

A physiologically based pharmacokinetic model for nicotine disposition in the Sprague-Dawley rat

ROLE OF PROLACTIN IN CHLORO-S-TRIAZINE RAT MAMMARY TUMORIGENESIS

MODE-OF-ACTION?BASED DOSIMETERS FOR INTERSPECIES EXTRAPOLATION OF VINYL ACETATE INHALATION RISK

Comparison of random and serial sections in assessment of ovarian toxicity

A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity

The nitrosation of nicotine: a kinetic study

Physiologically Based Modeling of Vinyl Acetate Uptake, Metabolism, and Intracellular pH Changes in the Rat Nasal Cavity

Phosphoramide mustard is responsible for the ovarian toxicity of cyclophosphamide

Reproductive toxicity of cyclophosphamide in the C57BL/6N mouse: 1. Effects on ovarian structure and function

Analysis of Vinyl Acetate Metabolism in Rat and Human Nasal Tissues by an in Vitro Gas Uptake Technique

Reproductive Toxicity: Male and Female Reproductive Systems as Targets for Chemical Injury

The Effect of Smoking on Oogenesis, Fertilization, and Implantation

The effect of benzo(a)pyrene on murine ovarian and corpora lutea volumes

Reproductive toxicity of cyclophosphamide in the C57BL/6N mouse: 2. Effects on uterine structure and function

Dosimetry of Vinyl Acetate in The Nasal Passages of Rats: Comparison of in Vitro and in Vivo Methods of Quantifying Metabolism

Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction

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