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Hematopoietic gene therapy restores thymidine phosphorylase activity in a cell culture and a murine model of MNGIE

Gene therapy, 2011-08, Vol.18 (8), p.795-806

2011

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p53-dependent suppression of uridine phosphorylase gene expression through direct promoter interaction

Cancer research (Chicago, Ill.), 2001-09, Vol.61 (18), p.6899-6905

2001

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Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines

The Journal of biological chemistry, 1991-04, Vol.266 (10), p.6181-6187

1991

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Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate

Thrombosis and haemostasis, 2013-06, Vol.109 (6), p.1108-1119

2013

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448 Regulation of uridine phosphorylase-2 redox-control mechanism to improve capecitabine selectivity

European journal of cancer supplements, 2010, Vol.8 (7), p.141-142

2010

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Dose-escalation and pharmacodynamic study of topotecan in combination with cyclophosphamide in patients with refractory cancer

Journal of clinical oncology, 1997-01, Vol.15 (1), p.148-157

1997

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Percutaneous hepatic vein isolation and high-dose hepatic arterial infusion chemotherapy for unresectable liver tumors

Journal of clinical oncology, 1994-12, Vol.12 (12), p.2723-2736

1994

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Abnormalities in Uridine Homeostatic Regulation and Pyrimidine Nucleotide Metabolism as a Consequence of the Deletion of the Uridine Phosphorylase Gene

The Journal of biological chemistry, 2005-06, Vol.280 (22), p.21169-21175

2005

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Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor

Clinical cancer research, 1998-05, Vol.4 (5), p.1165-1175

1998

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Results of retroviral and adenoviral approaches to cancer gene therapy

Stem cells (Dayton, Ohio), 1998, Vol.16 (S2), p.247-250

1998

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Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update

BBA - Molecular Basis of Disease, 2002-07, Vol.1587 (2), p.133-144

2002

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Cytosine Deaminase Adenoviral Vector and 5-Fluorocytosine Selectively Reduce Breast Cancer Cells 1 Million-Fold When They Contaminate Hematopoietic Cells: A Potential Purging Method for Autologous Transplantation

Blood, 1998-07, Vol.92 (2), p.672-682

1998

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Vector Targeting Makes 5-Fluorouracil Chemotherapy Less Toxic and More Effective in Animal Models of Epithelial Neoplasms

Clinical cancer research, 2004-11, Vol.10 (22), p.7738-7746

2004

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Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis

American journal of physiology: Gastrointestinal and liver physiology, 1998-06, Vol.274 (6), p.G1018-G1023

1998

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5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines

The Journal of biological chemistry, 1993-01, Vol.268 (2), p.1017-1023

1993

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Pharmacokinetic and phase I trial of intraperitoneal carboplatin and cyclosporine in refractory ovarian cancer patients

Journal of clinical oncology, 1997-05, Vol.15 (5), p.1945-1952

1997

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Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells

Molecular pharmacology, 2006-04, Vol.69 (4), p.1389-1395

2006

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Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines

Cancer research (Chicago, Ill.), 2002-04, Vol.62 (8), p.2313-2317

2002

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In vivo tumor lactate relaxation measurements by selective multiple-quantum-coherence (Sel-MQC) transfer

Magnetic resonance in medicine, 2004-10, Vol.52 (4), p.902-906

2004

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Adenoviral Vectors with E1A Regulated by Tumor-Specific Promoters Are Selectively Cytolytic for Breast Cancer and Melanoma

Molecular therapy, 2002-09, Vol.6 (3), p.386-393

2002

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Intracellular metabolism of 5,10-dideazatetrahydrofolic acid in human leukemia cell lines

Molecular pharmacology, 1991-01, Vol.39 (1), p.85-89

1991

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The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines

Cancer research (Chicago, Ill.), 2001-06, Vol.61 (11), p.4405

2001

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A phase I study of the antimetabolite (E)-2'-fluoromethylene-2'-deoxycytidine (MDL 101,731) administered as a twice-weekly infusion

The cancer journal (Sudbury, Mass.), 2000-09, Vol.6 (5), p.309

2000

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Antifolates: current developments

Cancer treatment and research, 1996, Vol.87, p.197

1996

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Pharmacokinetic and pharmacodynamic analysis of topotecan administered in combination with PS 341 in patients with advanced malignancy

Journal of clinical oncology, 2006-06, Vol.24 (18_suppl), p.2033-2033

2006

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Hematopoietic gene therapy restores thymidine phosphorylase activity in a cell culture and a murine model of MNGIE

p53-dependent suppression of uridine phosphorylase gene expression through direct promoter interaction

Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines

Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate

448 Regulation of uridine phosphorylase-2 redox-control mechanism to improve capecitabine selectivity

Dose-escalation and pharmacodynamic study of topotecan in combination with cyclophosphamide in patients with refractory cancer

Percutaneous hepatic vein isolation and high-dose hepatic arterial infusion chemotherapy for unresectable liver tumors

Abnormalities in Uridine Homeostatic Regulation and Pyrimidine Nucleotide Metabolism as a Consequence of the Deletion of the Uridine Phosphorylase Gene

Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor

Results of retroviral and adenoviral approaches to cancer gene therapy

Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update

Cytosine Deaminase Adenoviral Vector and 5-Fluorocytosine Selectively Reduce Breast Cancer Cells 1 Million-Fold When They Contaminate Hematopoietic Cells: A Potential Purging Method for Autologous Transplantation

Vector Targeting Makes 5-Fluorouracil Chemotherapy Less Toxic and More Effective in Animal Models of Epithelial Neoplasms

Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis

5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines

Pharmacokinetic and phase I trial of intraperitoneal carboplatin and cyclosporine in refractory ovarian cancer patients

Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells

Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines

In vivo tumor lactate relaxation measurements by selective multiple-quantum-coherence (Sel-MQC) transfer

Adenoviral Vectors with E1A Regulated by Tumor-Specific Promoters Are Selectively Cytolytic for Breast Cancer and Melanoma

Intracellular metabolism of 5,10-dideazatetrahydrofolic acid in human leukemia cell lines

The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines

A phase I study of the antimetabolite (E)-2'-fluoromethylene-2'-deoxycytidine (MDL 101,731) administered as a twice-weekly infusion

Antifolates: current developments

Pharmacokinetic and pharmacodynamic analysis of topotecan administered in combination with PS 341 in patients with advanced malignancy

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