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Regulation of sphingosine kinase and sphingolipid signaling

Trends in biochemical sciences (Amsterdam. Regular ed.), 2011-02, Vol.36 (2), p.97-107

Pitson, Stuart M.

2011

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The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity

Frontiers in oncology, 2018-10, Vol.8, p.431-431

2018

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Roles, regulation and inhibitors of sphingosine kinase 2

The FEBS journal, 2013-11, Vol.280 (21), p.5317-5336

2013

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Resistance to proteasome inhibitors and other targeted therapies in myeloma

British journal of haematology, 2018-07, Vol.182 (1), p.11-28

2018

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Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology

Progress in lipid research, 2018-10, Vol.72, p.42-54

2018

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Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion

Current biology, 2021-03, Vol.31 (6), p.1326-1336.e5

2021

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Venetoclax therapy and emerging resistance mechanisms in acute myeloid leukaemia

Cell death & disease, 2024-06, Vol.15 (6), p.413-11

2024

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Targeting the Sphingolipid System as a Therapeutic Direction for Glioblastoma

Cancers, 2020-01, Vol.12 (1), p.111

2020

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Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells

Oncotarget, 2016-03, Vol.7 (13), p.16663-16675

2016

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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Blood, 2017-02, Vol.129 (6), p.771-782

2017

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Characterising Distinct Migratory Profiles of Infiltrating T-Cell Subsets in Human Glioblastoma

Frontiers in immunology, 2022-04, Vol.13, p.850226-850226

2022

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Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet―Fed Mice

Diabetes (New York, N.Y.), 2012-12, Vol.61 (12), p.3148-3155

2012

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Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation

Nature medicine, 2014-08, Vol.20 (8), p.927-935

2014

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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD

PloS one, 2017-11, Vol.12 (11), p.e0179577-e0179577

2017

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FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

Cellular signalling, 2010-10, Vol.22 (10), p.1536-1542

2010

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A Drug Screening Pipeline Using 2D and 3D Patient-Derived In Vitro Models for Pre-Clinical Analysis of Therapy Response in Glioblastoma

International journal of molecular sciences, 2021-04, Vol.22 (9), p.4322

2021

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Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression

Cancer research (Chicago, Ill.), 2014-05, Vol.74 (10), p.2803-2815

2014

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The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

Scientific reports, 2022-01, Vol.12 (1), p.454-454, Article 454

2022

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GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma

Journal for immunotherapy of cancer, 2022-09, Vol.10 (9), p.e005187

2022

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Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition

Neoplasia (New York, N.Y.), 2022-01, Vol.24 (1), p.1-11

2022

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The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

The Journal of biological chemistry, 2010-12, Vol.285 (50), p.38841-38852

2010

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Targeting the integrated stress response in hematologic malignancies

Experimental hematology & oncology, 2022-11, Vol.11 (1), p.1-15, Article 94

2022

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Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

The Journal of biological chemistry, 2010-01, Vol.285 (1), p.483-492

2010

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Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways

PloS one, 2017-01, Vol.12 (1), p.e0169814

2017

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Regulation of sphingosine kinase and sphingolipid signaling

The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity

Roles, regulation and inhibitors of sphingosine kinase 2

Resistance to proteasome inhibitors and other targeted therapies in myeloma

Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology

Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion

Venetoclax therapy and emerging resistance mechanisms in acute myeloid leukaemia

Targeting the Sphingolipid System as a Therapeutic Direction for Glioblastoma

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Characterising Distinct Migratory Profiles of Infiltrating T-Cell Subsets in Human Glioblastoma

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet―Fed Mice

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation

Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

A Drug Screening Pipeline Using 2D and 3D Patient-Derived In Vitro Models for Pre-Clinical Analysis of Therapy Response in Glioblastoma

Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression

The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma

Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

Targeting the integrated stress response in hematologic malignancies

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

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