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Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.2895-2909

2018

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Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages

Innate immunity (London, England), 2021-04, Vol.27 (3), p.275-284

2021

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The synthetic glycolipid-based TLR4 antagonist FP7 negatively regulates in vitro and in vivo haematopoietic and non-haematopoietic vascular TLR4 signalling

Innate immunity (London, England), 2018-10, Vol.24 (7), p.411-421

2018

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Attenuation of proliferation in oligodendrocyte precursor cells by activated microglia

Journal of neuroscience research, 2010-06, Vol.88 (8), p.1632-1644

2010

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Differential Expression of FOXO1 and FOXO3a Confers Resistance to Oxidative Cell Death upon Endometrial Decidualization

Molecular endocrinology (Baltimore, Md.), 2006-10, Vol.20 (10), p.2444-2455

2006

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Elevation of plasma high-density lipoproteins inhibits development of experimental abdominal aortic aneurysms

Arteriosclerosis, thrombosis, and vascular biology, 2012-11, Vol.32 (11), p.2678-2686

2012

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Diabetes as a negative risk factor for abdominal aortic aneurysm - does the disease aetiology or the treatment provide the mechanism of protection?

Current vascular pharmacology, 2013-05, Vol.11 (3), p.293-298

2013

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Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

The Journal of neuroscience, 1997-09, Vol.17 (18), p.6952-6960

1997

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Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury

Journal of cerebral blood flow and metabolism, 2007-05, Vol.27 (5), p.1022-1032

2007

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Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm

Journal of vascular research, 2015-01, Vol.52 (2), p.81-93

2015

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Differentiation of human fetal mesenchymal stem cells into cells with an oligodendrocyte phenotype

Cell cycle (Georgetown, Tex.), 2009-04, Vol.8 (7), p.1069-1079

2009

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Differential role of apoptosis and autophagy associated with anticancer effect of lupulone (hop β-acid) derivatives on prostate cancer cells

Anti-cancer agents in medicinal chemistry, 2014-01, Vol.14 (8), p.1169-1178

2014

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Comparative proteomics reveals a systemic vulnerability in the vasculature of patients with abdominal aortic aneurysms

Journal of vascular surgery, 2011-10, Vol.54 (4), p.1100-1108.e6

2011

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A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development

Atherosclerosis, 2015-10, Vol.242 (2), p.563-570

2015

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Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.12261-12272

2021

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Abstract 486: A Novel Synthetic Glycolipid TLR4 Antagonist (FP7) Negatively Regulates in vitro and in vivo Hematopoietic and Non-Hematopoietic Vascular Toll Like Receptor 4 Signalling

Arteriosclerosis, thrombosis, and vascular biology, 2017-05, Vol.37 (suppl_1)

2017

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The Cyclopentenone 15-Deoxy-Δ12,14-Prostaglandin J2 Delays Lipopolysaccharide-Induced Preterm Delivery and Reduces Mortality in the Newborn Mouse

Endocrinology (Philadelphia), 2009-02, Vol.150 (2), p.699-706

2009

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Rosiglitazone negatively regulates c-Jun N-terminal kinase and toll-like receptor 4 proinflammatory signalling during initiation of experimental aortic aneurysms

Atherosclerosis, 2012-11, Vol.225 (1), p.69-75

2012

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Specific inhibition of c-Jun N-terminal kinase delays preterm labour and reduces mortality

Reproduction (Cambridge, England), 2015-10, Vol.150 (4), p.269-277

2015

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Abstract 483: EGR1 Mediates Suppression of PKD1 Expression, an Action Antagonized by Pioglitazone in Differentiated Angiotensin II-Treated THP-1 Cells

Arteriosclerosis, thrombosis, and vascular biology, 2014-05, Vol.34 (suppl_1)

2014

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Abstract 99: Rosiglitazone Negatively Regulates C-jun N-terminal Kinase and Toll-like Receptor 4 Proinflammatory Signaling During Initiation of Experimental Aortic Aneurysms

Arteriosclerosis, thrombosis, and vascular biology, 2012-05, Vol.32 (suppl_1)

2012

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Abstract 101: Reconstituted High-density Lipoprotein - More Than the Sum of Its Parts

Arteriosclerosis, thrombosis, and vascular biology, 2013-05, Vol.33 (suppl_1)

2013

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

Nature (London), 1996-06, Vol.381 (6585), p.800-803

1996

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An Investigation into the Anticancer Effects and Mechanism of Action of Hop [Beta]-Acid Lupulone and Its Natural and Synthetic Derivatives in Prostate Cancer Cells

Nutrition and cancer, 2013-10, Vol.65 (7), p.1086

2013

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Role of the eIF4E binding protein 4E-BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol-induced apoptosis

Biology of the cell, 2013-09, Vol.105 (9), p.414-429

2013

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Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists

Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages

The synthetic glycolipid-based TLR4 antagonist FP7 negatively regulates in vitro and in vivo haematopoietic and non-haematopoietic vascular TLR4 signalling

Attenuation of proliferation in oligodendrocyte precursor cells by activated microglia

Differential Expression of FOXO1 and FOXO3a Confers Resistance to Oxidative Cell Death upon Endometrial Decidualization

Elevation of plasma high-density lipoproteins inhibits development of experimental abdominal aortic aneurysms

Diabetes as a negative risk factor for abdominal aortic aneurysm - does the disease aetiology or the treatment provide the mechanism of protection?

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury

Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm

Differentiation of human fetal mesenchymal stem cells into cells with an oligodendrocyte phenotype

Differential role of apoptosis and autophagy associated with anticancer effect of lupulone (hop β-acid) derivatives on prostate cancer cells

Comparative proteomics reveals a systemic vulnerability in the vasculature of patients with abdominal aortic aneurysms

A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development

Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity

Abstract 486: A Novel Synthetic Glycolipid TLR4 Antagonist (FP7) Negatively Regulates in vitro and in vivo Hematopoietic and Non-Hematopoietic Vascular Toll Like Receptor 4 Signalling

The Cyclopentenone 15-Deoxy-Δ12,14-Prostaglandin J2 Delays Lipopolysaccharide-Induced Preterm Delivery and Reduces Mortality in the Newborn Mouse

Rosiglitazone negatively regulates c-Jun N-terminal kinase and toll-like receptor 4 proinflammatory signalling during initiation of experimental aortic aneurysms

Specific inhibition of c-Jun N-terminal kinase delays preterm labour and reduces mortality

Abstract 483: EGR1 Mediates Suppression of PKD1 Expression, an Action Antagonized by Pioglitazone in Differentiated Angiotensin II-Treated THP-1 Cells

Abstract 99: Rosiglitazone Negatively Regulates C-jun N-terminal Kinase and Toll-like Receptor 4 Proinflammatory Signaling During Initiation of Experimental Aortic Aneurysms

Abstract 101: Reconstituted High-density Lipoprotein - More Than the Sum of Its Parts

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

An Investigation into the Anticancer Effects and Mechanism of Action of Hop [Beta]-Acid Lupulone and Its Natural and Synthetic Derivatives in Prostate Cancer Cells

Role of the eIF4E binding protein 4E-BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol-induced apoptosis

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