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Tumor necrosis factor signaling

Cell death and differentiation, 2003-01, Vol.10 (1), p.45-65

2003

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Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L

Cell death and differentiation, 2007-12, Vol.14 (12), p.2021-2034

2007

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An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes

Journal of biotechnology, 2008-06, Vol.135 (2), p.217-223

2008

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TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy

Apoptosis (London), 2002-10, Vol.7 (5), p.449-459

2002

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Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity

Cell death & disease, 2012-04, Vol.3 (4), p.e295-e295

2012

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OMTX705, a powerful stroma-targeting ADC to treat invasive tumors with low response to immunotherapeutic anti-PD-1 treatments

Annals of oncology, 2018-10, Vol.29, p.viii414-viii414

2018

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Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor α in the nigrostriatal dopaminergic circuit of adult mice

Experimental neurology, 2011-02, Vol.227 (2), p.237-251

2011

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Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins

Cell death & disease, 2010-08, Vol.1 (8), p.e68-e68

2010

Volltextzugriff (PDF)

PKC zeta is a molecular switch in signal transduction of TNF‐alpha, bifunctionally regulated by ceramide and arachidonic acid

The EMBO journal, 1995-05, Vol.14 (9), p.1961-1969

1995

Volltextzugriff (PDF)

PKCu is a novel, atypical member of the protein kinase C family

The Journal of biological chemistry, 1994-02, Vol.269 (8), p.6140-6148

1994

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An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action

Protein engineering, design and selection, 2013-10, Vol.26 (10), p.581-587

2013

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Activation of CD95L fusion protein prodrugs by tumor-associated proteases

Cell death and differentiation, 2007-04, Vol.14 (4), p.765-774

2007

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Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex

Nature cell biology, 2005-09, Vol.7 (9), p.880-886

2005

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Protein Kinase C μ Is Regulated by the Multifunctional Chaperon Protein p32

The Journal of biological chemistry, 2000-08, Vol.275 (32), p.24601-24607

2000

Volltextzugriff (PDF)

Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway

The Journal of biological chemistry, 2004-07, Vol.279 (31), p.32869-32881

2004

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Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses

The Journal of immunology (1950), 1987-03, Vol.138 (6), p.1786

1987

Volltextzugriff (PDF)

Neurodegenerative and Neuroprotective Effects of Tumor Necrosis Factor (TNF) in Retinal Ischemia: Opposite Roles of TNF Receptor 1 and TNF Receptor 2

The Journal of neuroscience, 2002-04, Vol.22 (7), p.216-RC216

2002

Volltextzugriff (PDF)

Construction of a bispecific single chain antibody for recruitment of cytotoxic T cells to the tumour stroma associated antigen fibroblast activation protein

Journal of biotechnology, 2001-12, Vol.92 (2), p.159-168

2001

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Protein Kinase C μ Is Located at the Golgi Compartment

The Journal of cell biology, 1996-09, Vol.134 (6), p.1401-1410

1996

Volltextzugriff (PDF)

TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways

The Journal of immunology (1950), 1994-09, Vol.153 (5), p.1963

1994

Volltextzugriff (PDF)

Non-apoptotic Fas signaling

Cytokine & growth factor reviews, 2003-02, Vol.14 (1), p.53-66

2003

Volltextzugriff (PDF)

Tumor therapeutics by design: targeting and activation of death receptors

Cytokine & growth factor reviews, 2005-02, Vol.16 (1), p.55-76

2005

Volltextzugriff (PDF)

Species-crossreactive scFv against the tumor stroma marker "fibroblast activation protein" selected by phage display from an immunized FAP-/- knock-out mouse

Molecular medicine (Cambridge, Mass.), 2001-07, Vol.7 (7), p.461-469

2001

Volltextzugriff (PDF)

1200P - Tumour stroma targeting and modulation by OMTX705 ADC, a novel and potent immunotherapeutic treatment of solid tumours

Annals of oncology, 2019-10, Vol.30, p.v490-v490

2019

Volltextzugriff (PDF)

Tumour stroma targeting and modulation by OMTX705 ADC, a novel and potent immunotherapeutic treatment of solid tumours

Annals of oncology, 2019-10, Vol.30, p.v490

2019

Volltextzugriff (PDF)

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Tumor necrosis factor signaling

Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L

An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes

TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy

Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity

OMTX705, a powerful stroma-targeting ADC to treat invasive tumors with low response to immunotherapeutic anti-PD-1 treatments

Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor α in the nigrostriatal dopaminergic circuit of adult mice

Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins

PKC zeta is a molecular switch in signal transduction of TNF‐alpha, bifunctionally regulated by ceramide and arachidonic acid

PKCu is a novel, atypical member of the protein kinase C family

An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action

Activation of CD95L fusion protein prodrugs by tumor-associated proteases

Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex

Protein Kinase C μ Is Regulated by the Multifunctional Chaperon Protein p32

Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses

Neurodegenerative and Neuroprotective Effects of Tumor Necrosis Factor (TNF) in Retinal Ischemia: Opposite Roles of TNF Receptor 1 and TNF Receptor 2

Construction of a bispecific single chain antibody for recruitment of cytotoxic T cells to the tumour stroma associated antigen fibroblast activation protein

Protein Kinase C μ Is Located at the Golgi Compartment

TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways

Non-apoptotic Fas signaling

Tumor therapeutics by design: targeting and activation of death receptors

Species-crossreactive scFv against the tumor stroma marker "fibroblast activation protein" selected by phage display from an immunized FAP-/- knock-out mouse

1200P - Tumour stroma targeting and modulation by OMTX705 ADC, a novel and potent immunotherapeutic treatment of solid tumours

Tumour stroma targeting and modulation by OMTX705 ADC, a novel and potent immunotherapeutic treatment of solid tumours

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