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In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia

Blood, 2014-11, Vol.124 (20), p.3172-3174

2014

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Allosteric activation of coagulation factor VIIa

Frontiers in bioscience, 2011-06, Vol.16 (8), p.3156-3163

2011

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Beating tissue factor at its own game: Design and properties of a soluble tissue factor–independent coagulation factor VIIa

The Journal of biological chemistry, 2020-01, Vol.295 (2), p.517-528

2020

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Limited factor VIIa surface localization requirement of the factor VIIa–induced overall thrombin generation in platelet‐rich hemophilia A plasma

Research and practice in thrombosis and haemostasis, 2019-10, Vol.3 (4), p.713-717

2019

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The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors

The Journal of biological chemistry, 2011-02, Vol.286 (7), p.5756-5767

2011

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Reagent‐specific underestimation of turoctocog alfa pegol (N8‐GP) clotting activity owing to decelerated activation by thrombin

Research and practice in thrombosis and haemostasis, 2019-01, Vol.3 (1), p.114-120

2019

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Underestimation of N‐glycoPEGylated factor IX one‐stage clotting activity owing to contact activator‐impaired activation

Research and practice in thrombosis and haemostasis, 2017-10, Vol.1 (2), p.259-263

2017

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Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism

Research and practice in thrombosis and haemostasis, 2019-07, Vol.3 (3), p.412-419

2019

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Rational Design of Coagulation Factor VIIa Variants with Substantially Increased Intrinsic Activity

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (24), p.13583-13588

2001

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Engineering FVIIa Variants with Enhanced Activity

Blood, 2013-11, Vol.122 (21), p.SCI-7-SCI-7

Persson, Egon

2013

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Factor VII Tokushima (Cys22 → Gly) is not γ-carboxylated due to a disrupted γ-carboxylase recognition site

Thrombosis research, 2017-10, Vol.158, p.108-112

2017

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FIXing postinfusion monitoring: Assay experiences with N9‐GP (nonacog beta pegol; Refixia®; Rebinyn®)

Haemophilia : the official journal of the World Federation of Hemophilia, 2019-01, Vol.25 (1), p.154-161

2019

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Allosteric Activation of Coagulation Factor VIIa Visualized by Hydrogen Exchange

The Journal of biological chemistry, 2006-08, Vol.281 (32), p.23018-23024

2006

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The intricate allostery in factor VIIa: triggering the trigger

Journal of thrombosis and haemostasis, 2024-09

2024

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Novel molecules for the correction of factor Xa generation and phenotype in hemophilia

Thrombosis research, 2012-05, Vol.129, p.S51-S53

Persson, Egon

2012

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Fibrin gel structure obtained with a FVIIa analogue with enhanced FX-activating potential in haemophilia

Thrombosis and haemostasis, 2009-10, Vol.102 (4), p.790-792

2009

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Structure of Human Factor VIIa and Its Implications for the Triggering of Blood Coagulation

Proceedings of the National Academy of Sciences - PNAS, 1999-08, Vol.96 (16), p.8925-8930

1999

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The Origins of Enhanced Activity in Factor VIIa Analogs and the Interplay between Key Allosteric Sites Revealed by Hydrogen Exchange Mass Spectrometry

The Journal of biological chemistry, 2008-05, Vol.283 (19), p.13378-13387

2008

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Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement

Biochemical journal, 2004-04, Vol.379 (Pt 2), p.497-503

2004

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Limited factor VII a surface localization requirement of the factor VII a–induced overall thrombin generation in platelet‐rich hemophilia A plasma

Research and practice in thrombosis and haemostasis, 2019-10, Vol.3 (4), p.713-717

2019

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Mechanism of the Ca2+-induced Enhancement of the Intrinsic Factor VIIa Activity

The Journal of biological chemistry, 2008-09, Vol.283 (38), p.25863-25870

2008

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Protein disulfide isomerase has no stimulatory chaperone effect on factor X activation by factor VIIa-soluble tissue factor

Thrombosis research, 2008, Vol.123 (1), p.171-176

Persson, Egon

2008

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Substitution of Valine for Leucine 305 in Factor VIIa Increases the Intrinsic Enzymatic Activity

The Journal of biological chemistry, 2001-08, Vol.276 (31), p.29195-29199

2001

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Incorporation of an Active Site Inhibitor in Factor VIIa Alters the Affinity for Tissue Factor

The Journal of biological chemistry, 1997-05, Vol.272 (18), p.11863-11868

1997

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In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia

Allosteric activation of coagulation factor VIIa

A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models

Beating tissue factor at its own game: Design and properties of a soluble tissue factor–independent coagulation factor VIIa

Limited factor VIIa surface localization requirement of the factor VIIa–induced overall thrombin generation in platelet‐rich hemophilia A plasma

The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors

Reagent‐specific underestimation of turoctocog alfa pegol (N8‐GP) clotting activity owing to decelerated activation by thrombin

Underestimation of N‐glycoPEGylated factor IX one‐stage clotting activity owing to contact activator‐impaired activation

Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism

Rational Design of Coagulation Factor VIIa Variants with Substantially Increased Intrinsic Activity

Engineering FVIIa Variants with Enhanced Activity

Factor VII Tokushima (Cys22 → Gly) is not γ-carboxylated due to a disrupted γ-carboxylase recognition site

FIXing postinfusion monitoring: Assay experiences with N9‐GP (nonacog beta pegol; Refixia®; Rebinyn®)

Allosteric Activation of Coagulation Factor VIIa Visualized by Hydrogen Exchange

The intricate allostery in factor VIIa: triggering the trigger

Novel molecules for the correction of factor Xa generation and phenotype in hemophilia

Fibrin gel structure obtained with a FVIIa analogue with enhanced FX-activating potential in haemophilia

Structure of Human Factor VIIa and Its Implications for the Triggering of Blood Coagulation

The Origins of Enhanced Activity in Factor VIIa Analogs and the Interplay between Key Allosteric Sites Revealed by Hydrogen Exchange Mass Spectrometry

Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement

Limited factor VII a surface localization requirement of the factor VII a–induced overall thrombin generation in platelet‐rich hemophilia A plasma

Mechanism of the Ca2+-induced Enhancement of the Intrinsic Factor VIIa Activity

Protein disulfide isomerase has no stimulatory chaperone effect on factor X activation by factor VIIa-soluble tissue factor

Substitution of Valine for Leucine 305 in Factor VIIa Increases the Intrinsic Enzymatic Activity

Incorporation of an Active Site Inhibitor in Factor VIIa Alters the Affinity for Tissue Factor

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