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Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents

Blood, 2012-01, Vol.119 (4), p.1008-1017

2012

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Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

PloS one, 2015-12, Vol.10 (12), p.e0144660-e0144660

2015

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Targeted Fetal Hemoglobin Induction for Treatment of Beta Hemoglobinopathies

Hematology/oncology clinics of North America, 2014-04, Vol.28 (2), p.233-248

2014

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Advances in Virus-Directed Therapeutics against Epstein-Barr Virus-Associated Malignancies

Advances in Virology, 2012-01, Vol.2012 (2012), p.1-11

2012

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A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus–associated lymphoid malignancies

Blood, 2007-03, Vol.109 (6), p.2571-2578

2007

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Histone Deacetylase Inhibitors Reverse CpG Methylation by Regulating DNMT1 through ERK Signaling

Anticancer research, 2011-09, Vol.31 (9), p.2723-2732

2011

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Butyrate histone deacetylase inhibitors

BioResearch open access, 2012-08, Vol.1 (4), p.192-198

2012

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Switching globin, raising red cells

Blood, 2011-07, Vol.118 (4), p.834-836

Perrine, Susan P.

2011

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A randomized phase I/II trial of HQK‐1001, an oral fetal globin gene inducer, in β‐thalassaemia intermedia and HbE/β‐thalassaemia

British journal of haematology, 2013-05, Vol.161 (4), p.587-593

2013

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Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential

Pediatric annals, 2008-05, Vol.37 (5), p.339

Perrine, Susan P

2008

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A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia

Blood, 2014-03, Vol.123 (12), p.1956-1957

2014

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Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms

Blood cells, molecules, & diseases, 2016-01, Vol.56 (1), p.62-69

2016

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Fetal globin induction--can it cure beta thalassemia?

Hematology, 2005, Vol.2005 (1), p.38-44

Perrine, Susan P

2005

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A randomized phase II trial of Arginine Butyrate with standard local therapy in refractory sickle cell leg ulcers

British journal of haematology, 2010-12, Vol.151 (5), p.516-524

2010

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A dose‐escalation phase IIa study of 2,2‐dimethylbutyrate (HQK‐1001), an oral fetal globin inducer, in sickle cell disease

American journal of hematology, 2013-11, Vol.88 (11), p.E255-E260

2013

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Liquid chromatography–mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-02, Vol.862 (1), p.168-174

2008

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A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease

American journal of hematology, 2012-11, Vol.87 (11), p.1017-1021

2012

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An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo

Blood cells, molecules, & diseases, 2017-03, Vol.63, p.1-8

2017

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A phase 2 study of HQK‐1001, an oral fetal haemoglobin inducer, in β‐thalassaemia intermedia

British journal of haematology, 2014-02, Vol.164 (3), p.456-458

2014

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Fetal globin gene inducers: novel agents and new potential

Annals of the New York Academy of Sciences, 2010-08, Vol.1202 (1), p.158-164

2010

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Evaluation of Safety and Pharmacokinetics of Sodium 2,2 Dimethylbutyrate, a Novel Short Chain Fatty Acid Derivative, in a Phase 1, Double-Blind, Placebo-Controlled, Single-Dose, and Repeat-Dose Studies in Healthy Volunteers

Journal of clinical pharmacology, 2011-08, Vol.51 (8), p.1186-1194

2011

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Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex

Blood, 2006-11, Vol.108 (9), p.3179-3186

2006

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Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

Blood, 2002-12, Vol.100 (13), p.4640-4648

2002

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Erythroid Kruppel-like factor (EKLF) is recruited to the γ-globin gene promoter as a co-activator and is required for γ-globin gene induction by short-chain fatty acid derivatives

European journal of haematology, 2009-06, Vol.82 (6), p.466-476

2009

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Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo

Blood cells, molecules, & diseases, 2011-08, Vol.47 (2), p.107-116

2011

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Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents

Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

Targeted Fetal Hemoglobin Induction for Treatment of Beta Hemoglobinopathies

Advances in Virus-Directed Therapeutics against Epstein-Barr Virus-Associated Malignancies

A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus–associated lymphoid malignancies

Histone Deacetylase Inhibitors Reverse CpG Methylation by Regulating DNMT1 through ERK Signaling

Butyrate histone deacetylase inhibitors

Switching globin, raising red cells

A randomized phase I/II trial of HQK‐1001, an oral fetal globin gene inducer, in β‐thalassaemia intermedia and HbE/β‐thalassaemia

Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential

A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia

Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms

Fetal globin induction--can it cure beta thalassemia?

A randomized phase II trial of Arginine Butyrate with standard local therapy in refractory sickle cell leg ulcers

A dose‐escalation phase IIa study of 2,2‐dimethylbutyrate (HQK‐1001), an oral fetal globin inducer, in sickle cell disease

Liquid chromatography–mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma

A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease

An oral HemokineTM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo

A phase 2 study of HQK‐1001, an oral fetal haemoglobin inducer, in β‐thalassaemia intermedia

Fetal globin gene inducers: novel agents and new potential

Evaluation of Safety and Pharmacokinetics of Sodium 2,2 Dimethylbutyrate, a Novel Short Chain Fatty Acid Derivative, in a Phase 1, Double-Blind, Placebo-Controlled, Single-Dose, and Repeat-Dose Studies in Healthy Volunteers

Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex

Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

Erythroid Kruppel-like factor (EKLF) is recruited to the γ-globin gene promoter as a co-activator and is required for γ-globin gene induction by short-chain fatty acid derivatives

Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo

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