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Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease

Infectious disorders drug targets, 2006-03, Vol.6 (1), p.3-16

2006

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In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms

The Journal of biological chemistry, 2004-04, Vol.279 (17), p.17508-17514

2004

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Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

Antimicrobial Agents and Chemotherapy, 1998-12, Vol.42 (12), p.3179-3186

1998

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Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives

Journal of medicinal chemistry, 1998-09, Vol.41 (19), p.3645-3654

1998

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Phenylpropenamide derivatives as inhibitors of Hepatitis B virus replication

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (23), p.2687-2690

2000

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Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease

Antimicrobial Agents and Chemotherapy, 2006-03, Vol.50 (3), p.899-909

2006

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Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents

Journal of medicinal chemistry, 1995-07, Vol.38 (14), p.2531-2540

1995

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3-Quinolinecarboxamides. A series of novel orally-active antiherpetic agents

Journal of medicinal chemistry, 1993-05, Vol.36 (11), p.1580-1596

1993

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In Vitro Studies of Cross-resistance Mutations against Two Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061

The Journal of biological chemistry, 2005-11, Vol.280 (44), p.36784-36791

2005

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Cyclic Variations of 3-Quinolinecarboxamides and Effects on Antiherpetic Activity

Journal of medicinal chemistry, 1995-07, Vol.38 (14), p.2541-2545

1995

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Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative

Journal of medicinal chemistry, 1988-09, Vol.31 (9), p.1694-1697

1988

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An enantioselective and highly convergent synthesis of (+)-ikarugamycin

Journal of the American Chemical Society, 1989-09, Vol.111 (20), p.8036-8037

1989

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Solid sorbent for sampling acrolein in air

Analytical chemistry (Washington), 1978-11, Vol.50 (13), p.1839-1841

1978

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Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN 33377) and related derivatives

Bioorganic & medicinal chemistry letters, 1994-02, Vol.4 (4), p.609-614

1994

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Synthesis of .alpha.-substituted 1,2-benzenedimethanamines

Journal of organic chemistry, 1991-08, Vol.56 (17), p.5218-5221

1991

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4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: Novel antiarrhythmic agents

Journal of medicinal chemistry, 1993-10, Vol.36 (22), p.3361-3370

1993

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Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition

Bioorganic & medicinal chemistry letters, 1993-08, Vol.3 (8), p.1711-1716

1993

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Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)β-l-2'3'-dideoxy-3'-thiacytidine

Antimicrobial agents and chemotherapy, 1998, Vol.42 (12), p.3179-3186

1998

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Amberlyst-15 as a Convenient Catalyst for Chemoselective Thioacetalization

Synthetic communications, 1989-08, Vol.19 (13-14), p.2383-2387

Perni, Robert B.

1989

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NS3.4A protease as a target for interfering with hepatitis C virus replication

Drug news & perspectives, 2000-03, Vol.13 (2), p.69-77

Perni, R B

2000

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An Efficient One-Pot Synthesis of Hippuric Acid Ethyl Ester Derivatives

Synthetic communications, 1998-05, Vol.28 (9), p.1539-1545

1998

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The antitumor activity of novel pyrazoloquinoline derivatives

Bioorganic & medicinal chemistry letters, 1995-02, Vol.5 (4), p.405-410

1995

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Twin benzoannulation of naphthalene via 1,3-, 1,6-, and 2,6-naphthodiyne synthetic equivalents: new syntheses of triphenylene, benz[a]anthracene, and naphthacene

Journal of organic chemistry, 1985-02, Vol.50 (16), p.2934-2939

1985

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Studies directed toward the synthesis of naturally occurring acyltetramic acids. 2. Preparation of the macrocyclic subunit of ikarugamycin

Journal of organic chemistry, 1986-12, Vol.51 (26), p.5486-5489

1986

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Antiviral properties of 3-quinolinecarboxamides: a series of novel non-nucleoside antiherpetic agents

Drug design and discovery, 1997-05, Vol.15 (1), p.25

1997

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Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease

In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine

Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives

Phenylpropenamide derivatives as inhibitors of Hepatitis B virus replication

Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease

Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents

3-Quinolinecarboxamides. A series of novel orally-active antiherpetic agents

In Vitro Studies of Cross-resistance Mutations against Two Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061

Cyclic Variations of 3-Quinolinecarboxamides and Effects on Antiherpetic Activity

Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative

An enantioselective and highly convergent synthesis of (+)-ikarugamycin

Solid sorbent for sampling acrolein in air

Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN 33377) and related derivatives

Synthesis of .alpha.-substituted 1,2-benzenedimethanamines

4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: Novel antiarrhythmic agents

Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition

Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)β-l-2'3'-dideoxy-3'-thiacytidine

Amberlyst-15 as a Convenient Catalyst for Chemoselective Thioacetalization

NS3.4A protease as a target for interfering with hepatitis C virus replication

An Efficient One-Pot Synthesis of Hippuric Acid Ethyl Ester Derivatives

The antitumor activity of novel pyrazoloquinoline derivatives

Twin benzoannulation of naphthalene via 1,3-, 1,6-, and 2,6-naphthodiyne synthetic equivalents: new syntheses of triphenylene, benz[a]anthracene, and naphthacene

Studies directed toward the synthesis of naturally occurring acyltetramic acids. 2. Preparation of the macrocyclic subunit of ikarugamycin

Antiviral properties of 3-quinolinecarboxamides: a series of novel non-nucleoside antiherpetic agents

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