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Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

PloS one, 2013-06, Vol.8 (6), p.e66226

2013

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Riluzole prodrugs for melanoma and ALS: Design, synthesis, and in vitro metabolic profiling

Bioorganic & medicinal chemistry, 2012-09, Vol.20 (18), p.5642-5648

2012

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8-Hydroxyquinoline and hydroxamic acid inhibitors of botulinum neurotoxin BoNT/A

Current topics in medicinal chemistry, 2014-01, Vol.14 (18), p.2094-2102

2014

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A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

Journal of medicinal chemistry, 2019-06, Vol.62 (11), p.5298-5311

2019

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A Spontaneous Melanoma Mouse Model Applicable for a Longitudinal Chemotherapy and Immunotherapy Study

Journal of investigative dermatology, 2023-10, Vol.143 (10), p.2007-2018.e6

2023

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Highly potent, broadly active antifungal agents for the treatment of invasive fungal infections

Bioorganic & medicinal chemistry letters, 2021-02, Vol.33, p.127727-127727, Article 127727

2021

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Correction to “A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction”

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8649-8649

2020

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Identification of Clinically Viable Quinolinol Inhibitors of Botulinum Neurotoxin A Light Chain

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.669-676

2014

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Amide- and bis-amide-linked highly potent and broadly active antifungal agents for the treatment of invasive fungal infections- towards the discovery of pre-clinical development candidate FC12406

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1436-1452

2023

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Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

ACS chemical neuroscience, 2015-04, Vol.6 (4), p.666-680

2015

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Assessing Longitudinal Treatment Efficacies and Alterations in Molecular Markers Associated with Glutamatergic Signaling and Immune Checkpoint Inhibitors in a Spontaneous Melanoma Mouse Model

JID innovations, 2024-03, Vol.4 (2), p.100262-100262, Article 100262

2024

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Dipeptide Prodrugs of the Glutamate Modulator Riluzole

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.752-756

2018

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Improved Solid-Phase Peptide Synthesis Method Utilizing α-Azide-Protected Amino Acids

Organic letters, 2001-03, Vol.3 (5), p.781-783

2001

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Intramolecular rearrangement of α-amino acid amide derivatives of 2-aminobenzothiazoles

Tetrahedron letters, 2014-07, Vol.55 (30), p.4193-4195

2014

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7-Azabicycloheptane Carboxylic Acid: A Proline Replacement in a Boroarginine Thrombin Inhibitor

Organic letters, 1999-12, Vol.1 (12), p.1875-1877

1999

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(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A Wingless β-Catenin Agonist That Increases Bone Formation Rate

Journal of medicinal chemistry, 2009-11, Vol.52 (22), p.6962-6965

2009

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2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor

Bioorganic & medicinal chemistry, 2008-07, Vol.16 (13), p.6617-6640

2008

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Tricyclic ureas: A new class of HIV-1 protease inhibitors

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (24), p.3615-3620

1998

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Mild and Adaptable Silver Triflate-Assisted Method for Trityl Protection of Alcohols in Solution with Solid-Phase Loading Applications

Organic letters, 2006-08, Vol.8 (18), p.3915-3918

2006

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Mitsunobu reaction modifications allowing product isolation without chromatography: application to a small parallel library

Tetrahedron letters, 2000-02, Vol.41 (6), p.797-800

2000

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Preparation of highly substituted γ-lactam follicle stimulating hormone receptor agonists

Bioorganic & medicinal chemistry, 2005-11, Vol.13 (21), p.5986-5995

2005

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Discovery of 6-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): An Orally Active Antagonist of the Gonadotropin Releasing Hormone Receptor (GnRH-R)

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.2148-2152

2009

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A New Tri-Orthogonal Strategy for Peptide Cyclization

Organic letters, 2002-09, Vol.4 (19), p.3219-3221

2002

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Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2512-2515

2010

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Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor : Structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.1986-1990

2009

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Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction

Riluzole prodrugs for melanoma and ALS: Design, synthesis, and in vitro metabolic profiling

8-Hydroxyquinoline and hydroxamic acid inhibitors of botulinum neurotoxin BoNT/A

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

A Spontaneous Melanoma Mouse Model Applicable for a Longitudinal Chemotherapy and Immunotherapy Study

Highly potent, broadly active antifungal agents for the treatment of invasive fungal infections

Correction to “A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction”

Identification of Clinically Viable Quinolinol Inhibitors of Botulinum Neurotoxin A Light Chain

Amide- and bis-amide-linked highly potent and broadly active antifungal agents for the treatment of invasive fungal infections- towards the discovery of pre-clinical development candidate FC12406

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models

Assessing Longitudinal Treatment Efficacies and Alterations in Molecular Markers Associated with Glutamatergic Signaling and Immune Checkpoint Inhibitors in a Spontaneous Melanoma Mouse Model

Dipeptide Prodrugs of the Glutamate Modulator Riluzole

Improved Solid-Phase Peptide Synthesis Method Utilizing α-Azide-Protected Amino Acids

Intramolecular rearrangement of α-amino acid amide derivatives of 2-aminobenzothiazoles

7-Azabicycloheptane Carboxylic Acid: A Proline Replacement in a Boroarginine Thrombin Inhibitor

(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A Wingless β-Catenin Agonist That Increases Bone Formation Rate

2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor

Tricyclic ureas: A new class of HIV-1 protease inhibitors

Mild and Adaptable Silver Triflate-Assisted Method for Trityl Protection of Alcohols in Solution with Solid-Phase Loading Applications

Mitsunobu reaction modifications allowing product isolation without chromatography: application to a small parallel library

Preparation of highly substituted γ-lactam follicle stimulating hormone receptor agonists

Discovery of 6-({4-[2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): An Orally Active Antagonist of the Gonadotropin Releasing Hormone Receptor (GnRH-R)

A New Tri-Orthogonal Strategy for Peptide Cyclization

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor : Structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template

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