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Glycolysis inhibition for anticancer treatment

Oncogene, 2006-08, Vol.25 (34), p.4633-4646

2006

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Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells

Leukemia, 2014-01, Vol.28 (1), p.118-128

2014

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Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

Oncogene, 2016-10, Vol.35 (43), p.5663-5673

2016

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Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells

Leukemia, 2005-12, Vol.19 (12), p.2153-2158

2005

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Interaction of p53 and DNA-PK in response to nucleoside analogues: Potential role as a sensor complex for DNA damage

Cancer research (Chicago, Ill.), 2001-12, Vol.61 (24), p.8723-8729

2001

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ROS stress in cancer cells and therapeutic implications

Drug resistance updates, 2004-04, Vol.7 (2), p.97-110

2004

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Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C

Leukemia, 2006-04, Vol.20 (4), p.610-619

2006

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The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

Cell, 2002-10, Vol.111 (1), p.41-50

2002

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Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia

Cancer research (Chicago, Ill.), 2005-01, Vol.65 (2), p.613-621

2005

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Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism

The Journal of biological chemistry, 2003-09, Vol.278 (39), p.37832-37839

2003

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Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ

The EMBO journal, 2005-10, Vol.24 (19), p.3482-3492

2005

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Simultaneous inhibition of PDK1/AKT and fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

Cancer research (Chicago, Ill.), 2006-04, Vol.66 (7), p.3737-3746

2006

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Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia

OncoTargets and therapy, 2018-01, Vol.11, p.5151-5170

2018

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Role of p53 in cellular response to anticancer nucleoside analog-induced DNA damage

International journal of molecular medicine, 2000-06, Vol.5 (6), p.597

2000

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A Novel Mechanism of Action of Methyl-2-cyano-3,12 Dioxoolean-1,9 Diene-28-oate: Direct Permeabilization of the Inner Mitochondrial Membrane to Inhibit Electron Transport and Induce Apoptosis

Molecular pharmacology, 2006-04, Vol.69 (4), p.1182-1193

2006

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OSW-1: a Natural Compound With Potent Anticancer Activity and a Novel Mechanism of Action

JNCI : Journal of the National Cancer Institute, 2005-12, Vol.97 (23), p.1781-1785

2005

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Stabilization of p53 Is a Novel Mechanism for Proapoptotic Function of NF-κB

The Journal of biological chemistry, 2004-06, Vol.279 (26), p.27549-27559

2004

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Loss of p53 and altered miR15-a/16-1[right arrow]MCL-1 pathway in CLL: insights from TCL1-Tg:p53^sup -/-^ mouse model and primary human leukemia cells

Leukemia, 2014-01, Vol.28 (1), p.118

2014

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Loss of p53 and altered miR15-a/16-1 arrow right MCL-1 pathway in CLL: insights from TCL1-Tg:p53 super(-/-) mouse model and primary human leukemia cells

Leukemia, 2014-01, Vol.28 (1), p.118-128

2014

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Loss of p53 and altered miR15-a/16-1 [right arrow] MCL-1 pathway in CLL: insights from TCL1-Tg:[p53.sup.-/-] mouse model and primary human leukemia cells

Leukemia, 2014-01, Vol.28 (1), p.118

2014

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Alterations of cellular redox state during NNK-induced malignant transformation and resistance to radiation

Antioxidants & redox signaling, 2008-05, Vol.10 (5), p.951

2008

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Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells

Blood, 2004-03, Vol.103 (5), p.1846-1854

2004

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Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response

Molecular pharmacology, 2002-01, Vol.61 (1), p.222-229

2002

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Glycolysis inhibition for anticancer treatment: Mitochondria and cancer

Oncogene, 2006, Vol.25 (34), p.4633-4646

2006

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Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

Journal of medicinal chemistry, 1996-12, Vol.39 (25), p.4958-4965

1996

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Glycolysis inhibition for anticancer treatment

Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells

Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells

Interaction of p53 and DNA-PK in response to nucleoside analogues: Potential role as a sensor complex for DNA damage

ROS stress in cancer cells and therapeutic implications

Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C

The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia

Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism

Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ

Simultaneous inhibition of PDK1/AKT and fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia

Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia

Role of p53 in cellular response to anticancer nucleoside analog-induced DNA damage

A Novel Mechanism of Action of Methyl-2-cyano-3,12 Dioxoolean-1,9 Diene-28-oate: Direct Permeabilization of the Inner Mitochondrial Membrane to Inhibit Electron Transport and Induce Apoptosis

OSW-1: a Natural Compound With Potent Anticancer Activity and a Novel Mechanism of Action

Stabilization of p53 Is a Novel Mechanism for Proapoptotic Function of NF-κB

Loss of p53 and altered miR15-a/16-1[right arrow]MCL-1 pathway in CLL: insights from TCL1-Tg:p53^sup -/-^ mouse model and primary human leukemia cells

Loss of p53 and altered miR15-a/16-1 arrow right MCL-1 pathway in CLL: insights from TCL1-Tg:p53 super(-/-) mouse model and primary human leukemia cells

Loss of p53 and altered miR15-a/16-1 [right arrow] MCL-1 pathway in CLL: insights from TCL1-Tg:[p53.sup.-/-] mouse model and primary human leukemia cells

Alterations of cellular redox state during NNK-induced malignant transformation and resistance to radiation

Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells

Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response

Glycolysis inhibition for anticancer treatment: Mitochondria and cancer

Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

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