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Impact of enzyme turnover on the dynamics of the Michaelis–Menten model

Mathematical biosciences, 2022-04, Vol.346, p.108795-108795, Article 108795

2022

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Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification

Journal of pharmacokinetics and pharmacodynamics, 2012-10, Vol.39 (5), p.429-451

2012

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An Extended Model Including Target Turnover, Ligand-Target Complex Kinetics, and Binding Properties to Describe Drug-Receptor Interactions

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2385, p.19

Peletier, Lambertus A

2022

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The quest for balance between capturing data and model complexity: A quantitative clinical pharmacology approach applied to monoclonal antibodies

CPT: pharmacometrics and systems pharmacology, 2023-05, Vol.12 (5), p.639-655

2023

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In vivo potency revisited – Keep the target in sight

Pharmacology & therapeutics (Oxford), 2018-04, Vol.184, p.177-188

2018

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Michaelis-Menten from an In Vivo Perspective: Open Versus Closed Systems

The AAPS journal, 2018-11, Vol.20 (6), p.102-102, Article 102

2018

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Pharmacokinetic Steady-States Highlight Interesting Target-Mediated Disposition Properties

The AAPS journal, 2017-05, Vol.19 (3), p.772-786

2017

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Comparisons of basic target-mediated drug disposition (TMDD) and ligand facilitated target removal (LFTR)

European journal of pharmaceutical sciences, 2021-07, Vol.162, p.105835-105835, Article 105835

2021

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New Equilibrium Models of Drug-Receptor Interactions Derived from Target-Mediated Drug Disposition

The AAPS journal, 2018-07, Vol.20 (4), p.69-69, Article 69

2018

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Lost in translation: What's in an EC50? Innovative PK/PD reasoning in the drug development context

European journal of pharmacology, 2018-09, Vol.835, p.154-161

2018

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Revisit ligand-receptor interaction at the human vasopressin V 2 receptor: A kinetic perspective

European journal of pharmacology, 2020-08, Vol.880, p.173157

2020

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Dose–response–time data analysis involving nonlinear dynamics, feedback and delay

European journal of pharmaceutical sciences, 2014-08, Vol.59, p.36-48

2014

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Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective

European journal of pharmacology, 2020-08, Vol.880, p.173157-173157, Article 173157

2020

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Mixture dynamics: Combination therapy in oncology

European journal of pharmaceutical sciences, 2016-06, Vol.88, p.132-146

2016

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Impact of mathematical pharmacology on practice and theory: four case studies

Journal of pharmacokinetics and pharmacodynamics, 2018-02, Vol.45 (1), p.3-21

2018

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Dynamics of target-mediated drug disposition

European journal of pharmaceutical sciences, 2009-12, Vol.38 (5), p.445-464

2009

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Predicting the Onset of Nonlinear Pharmacokinetics

CPT: pharmacometrics and systems pharmacology, 2018-10, Vol.7 (10), p.670-677

2018

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A two‐state model for the kinetics of competitive radioligand binding

British journal of pharmacology, 2018-05, Vol.175 (10), p.1719-1730

2018

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Use of mathematics to guide target selection in systems pharmacology; application to receptor tyrosine kinase (RTK) pathways

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.S140-S148

2017

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Mathematical modeling of the glucagon challenge test

Journal of pharmacokinetics and pharmacodynamics, 2019-12, Vol.46 (6), p.553-564

2019

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Mixture dynamics: Dual action of inhibition and stimulation

European journal of pharmaceutical sciences, 2013-10, Vol.50 (2), p.215-226

2013

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Correction to: Mathematical Modelling of Alternative Pathway of Complement System

Bulletin of mathematical biology, 2022, Vol.84 (1), p.18-18, Article 18

2022

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Mathematical Modelling of Alternative Pathway of Complement System

Bulletin of mathematical biology, 2020-02, Vol.82 (2), p.33-33, Article 33

2020

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Topics in Mathematical Pharmacology

Journal of dynamics and differential equations, 2016-09, Vol.28 (3-4), p.1337-1356

2016

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Impact of saturable distribution in compartmental PK models: dynamics and practical use

Journal of pharmacokinetics and pharmacodynamics, 2017-02, Vol.44 (1), p.1-16

2017

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Impact of enzyme turnover on the dynamics of the Michaelis–Menten model

Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification

An Extended Model Including Target Turnover, Ligand-Target Complex Kinetics, and Binding Properties to Describe Drug-Receptor Interactions

The quest for balance between capturing data and model complexity: A quantitative clinical pharmacology approach applied to monoclonal antibodies

In vivo potency revisited – Keep the target in sight

Michaelis-Menten from an In Vivo Perspective: Open Versus Closed Systems

Pharmacokinetic Steady-States Highlight Interesting Target-Mediated Disposition Properties

Comparisons of basic target-mediated drug disposition (TMDD) and ligand facilitated target removal (LFTR)

New Equilibrium Models of Drug-Receptor Interactions Derived from Target-Mediated Drug Disposition

Lost in translation: What's in an EC50? Innovative PK/PD reasoning in the drug development context

Revisit ligand-receptor interaction at the human vasopressin V 2 receptor: A kinetic perspective

Dose–response–time data analysis involving nonlinear dynamics, feedback and delay

Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective

Mixture dynamics: Combination therapy in oncology

Impact of mathematical pharmacology on practice and theory: four case studies

Dynamics of target-mediated drug disposition

Predicting the Onset of Nonlinear Pharmacokinetics

A two‐state model for the kinetics of competitive radioligand binding

Use of mathematics to guide target selection in systems pharmacology; application to receptor tyrosine kinase (RTK) pathways

Mathematical modeling of the glucagon challenge test

Mixture dynamics: Dual action of inhibition and stimulation

Correction to: Mathematical Modelling of Alternative Pathway of Complement System

Mathematical Modelling of Alternative Pathway of Complement System

Topics in Mathematical Pharmacology

Impact of saturable distribution in compartmental PK models: dynamics and practical use

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