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Bioactivity descriptors for uncharacterized chemical compounds

Nature communications, 2021-06, Vol.12 (1), p.3932-3932, Article 3932

2021

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Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice

The Journal of immunology (1950), 2013-09, Vol.191 (5), p.2717-2730

2013

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Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

The Journal of immunology (1950), 2014-08, Vol.193 (4), p.1988-1997

2014

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p21 regulates the HIV-1 restriction factor SAMHD1

Proceedings of the National Academy of Sciences - PNAS, 2014-04, Vol.111 (14), p.E1322-E1324

2014

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Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1

The Journal of immunology (1950), 2013-05, Vol.190 (9), p.4736-4741

2013

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The cortical actin determines different susceptibility of naïve and memory CD4+ T cells to HIV-1 cell-to-cell transmission and infection

PloS one, 2013-11, Vol.8 (11), p.e79221-e79221

2013

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HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro

AIDS (London), 2008-01, Vol.22 (1), p.23-31

2008

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Anti-HIV Activity and Resistance Profile of the CXC Chemokine Receptor 4 Antagonist POL3026

Molecular pharmacology, 2008-04, Vol.73 (4), p.1264-1273

2008

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Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker

Nature biotechnology, 2020-09, Vol.38 (9), p.1087

2020

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Inhibition of HIV-1 replication by RNA interference of p53 expression

Journal of leukocyte biology, 2006-09, Vol.80 (3), p.659-667

2006

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Inhibition of Coreceptor-Independent Cell-to-Cell Human Immunodeficiency Virus Type 1 Transmission by a CD4-Immunoglobulin G2 Fusion Protein

Antimicrobial Agents and Chemotherapy, 2005-10, Vol.49 (10), p.4296-4304

2005

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Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.183-196

2015

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Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1

Journal of antimicrobial chemotherapy, 2016-02, Vol.71 (2), p.387-394

2016

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Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

AIDS (London), 2014-09, Vol.28 (15), p.2213-2222

2014

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Bioactivity Profile Similarities to Expand the Repertoire of COVID-19 Drugs

Journal of chemical information and modeling, 2020-12, Vol.60 (12), p.5730-5734

2020

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Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages

Cell cycle (Georgetown, Tex.), 2015-01, Vol.14 (11), p.1657-1665

2015

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Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

The Journal of biological chemistry, 2012-06, Vol.287 (23), p.19216-19228

2012

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SAMHD1 Specifically Affects the Antiviral Potency of Thymidine Analog HIV Reverse Transcriptase Inhibitors

Antimicrobial agents and chemotherapy, 2014-08, Vol.58 (8), p.4804-4813

2014

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SAMHD1 is active in cycling cells permissive to HIV-1 infection

Antiviral research, 2017-06, Vol.142, p.123-135

2017

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Characterization of the Influence of Mediator Complex in HIV-1 Transcription

The Journal of biological chemistry, 2014-10, Vol.289 (40), p.27665-27676

2014

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Zinc Finger Endonuclease Targeting PSIP1 Inhibits HIV-1 Integration

Antimicrobial agents and chemotherapy, 2014-08, Vol.58 (8), p.4318-4327

2014

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Increased expression of SAMHD1 in a subset of HIV-1 elite controllers

Journal of antimicrobial chemotherapy, 2014-11, Vol.69 (11), p.3057-3060

2014

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Nucleotide embargo by SAMHD1: A strategy to block retroviral infection

Antiviral research, 2013-02, Vol.97 (2), p.180-182

2013

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Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models

Genome medicine, 2021-10, Vol.13 (1), p.1-168, Article 168

2021

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Trans-infection but Not Infection from within Endosomal Compartments after Cell-to-cell HIV-1 Transfer to CD4+ T Cells

The Journal of biological chemistry, 2012-09, Vol.287 (38), p.32017-32026

2012

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Bioactivity descriptors for uncharacterized chemical compounds

Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

p21 regulates the HIV-1 restriction factor SAMHD1

Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1

The cortical actin determines different susceptibility of naïve and memory CD4+ T cells to HIV-1 cell-to-cell transmission and infection

HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro

Anti-HIV Activity and Resistance Profile of the CXC Chemokine Receptor 4 Antagonist POL3026

Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker

Inhibition of HIV-1 replication by RNA interference of p53 expression

Inhibition of Coreceptor-Independent Cell-to-Cell Human Immunodeficiency Virus Type 1 Transmission by a CD4-Immunoglobulin G2 Fusion Protein

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1

Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

Bioactivity Profile Similarities to Expand the Repertoire of COVID-19 Drugs

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages

Essential Role for IKKβ in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells

SAMHD1 Specifically Affects the Antiviral Potency of Thymidine Analog HIV Reverse Transcriptase Inhibitors

SAMHD1 is active in cycling cells permissive to HIV-1 infection

Characterization of the Influence of Mediator Complex in HIV-1 Transcription

Zinc Finger Endonuclease Targeting PSIP1 Inhibits HIV-1 Integration

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers

Nucleotide embargo by SAMHD1: A strategy to block retroviral infection

Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models

Trans-infection but Not Infection from within Endosomal Compartments after Cell-to-cell HIV-1 Transfer to CD4+ T Cells

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