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Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma

Journal of investigative dermatology, 2017-08, Vol.137 (8), p.1740-1748

2017

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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

The Journal of clinical investigation, 2012-02, Vol.122 (2), p.639-653

2012

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Kras as a key oncogene and therapeutic target in pancreatic cancer

Frontiers in physiology, 2014, Vol.4, p.407-407

2014

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Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

eLife, 2023-05, Vol.12

2023

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Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway

eLife, 2022-02, Vol.11

2022

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Arginase 1 is a key driver of immune suppression in pancreatic cancer

eLife, 2023-02, Vol.12

2023

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Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling

Cell reports (Cambridge), 2014-10, Vol.9 (2), p.484-494

2014

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Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

Cancer immunology research, 2016-06, Vol.4 (6), p.520-530

2016

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Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

Cell metabolism, 2019-06, Vol.29 (6), p.1390-1399.e6

2019

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Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

eLife, 2017-10, Vol.6

2017

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Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy

Cancer research (Chicago, Ill.), 2019-08, Vol.79 (15), p.3940-3951

2019

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c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target

Gastroenterology (New York, N.Y. 1943), 2011-12, Vol.141 (6), p.2218-2227.e5

2011

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Hedgehog signalling in cancer formation and maintenance

Nature reviews. Cancer, 2003-12, Vol.3 (12), p.903-911

2003

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Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice

Gastroenterology (New York, N.Y. 1943), 2020-04, Vol.158 (5), p.1417-1432.e11

2020

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Cleaved CDCP1 marks the spot: a neoepitope for RAS-driven cancers

The Journal of clinical investigation, 2022-02, Vol.132 (4)

2022

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GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer

Cancer discovery, 2016-08, Vol.6 (8), p.886-899

2016

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Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

Cancer research (Chicago, Ill.), 2013-08, Vol.73 (15), p.4909-4922

2013

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Discoidin Domain Receptor 1 (DDR1) Is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma

The American journal of pathology, 2020-08, Vol.190 (8), p.1735-1751

2020

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Targeting glycans for CAR therapy: The advent of sweet CARs

Molecular therapy, 2022-09, Vol.30 (9), p.2881-2890

2022

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Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer

Oncogene, 2021-04, Vol.40 (17), p.3118-3135

2021

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MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice

Gastroenterology (New York, N.Y. 1943), 2014-03, Vol.146 (3), p.822-834.e7

2014

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Deciphering the role of stroma in pancreatic cancer

Current opinion in gastroenterology, 2013-09, Vol.29 (5), p.537-543

2013

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Stepwise Activation of Enhancer and Promoter Regions of the B Cell Commitment Gene Pax5 in Early Lymphopoiesis

Immunity (Cambridge, Mass.), 2009-04, Vol.30 (4), p.508-520

2009

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Hedgehog/Ras interactions regulate early stages of pancreatic cancer

Genes & development, 2006-11, Vol.20 (22), p.3161-3173

2006

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Pancreatic cancer: Advances and challenges

Cell, 2023-04, Vol.186 (8), p.1729-1754

2023

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Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

Kras as a key oncogene and therapeutic target in pancreatic cancer

Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway

Arginase 1 is a key driver of immune suppression in pancreatic cancer

Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy

c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target

Hedgehog signalling in cancer formation and maintenance

Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice

Cleaved CDCP1 marks the spot: a neoepitope for RAS-driven cancers

GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

Discoidin Domain Receptor 1 (DDR1) Is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma

Targeting glycans for CAR therapy: The advent of sweet CARs

Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer

MAPK Signaling Is Required for Dedifferentiation of Acinar Cells and Development of Pancreatic Intraepithelial Neoplasia in Mice

Deciphering the role of stroma in pancreatic cancer

Stepwise Activation of Enhancer and Promoter Regions of the B Cell Commitment Gene Pax5 in Early Lymphopoiesis

Hedgehog/Ras interactions regulate early stages of pancreatic cancer

Pancreatic cancer: Advances and challenges

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