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DNA repair function scores for 2172 variants in the BRCA1 amino-terminus

PLoS genetics, 2023-08, Vol.19 (8), p.e1010739-e1010739

2023

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A Multiplex Homology-Directed DNA Repair Assay Reveals the Impact of More Than 1,000 BRCA1 Missense Substitution Variants on Protein Function

American journal of human genetics, 2018-10, Vol.103 (4), p.498-508

2018

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Massively Parallel Functional Analysis of BRCA1 RING Domain Variants

Genetics (Austin), 2015-06, Vol.200 (2), p.413-422

2015

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Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells

PloS one, 2021-01, Vol.16 (1), p.e0235025

2021

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Multiplexed assay of variant effect reveals residues of functional importance in the BRCA1 coiled-coil and serine cluster domains

PloS one, 2023-11, Vol.18 (11), p.e0293422-e0293422

2023

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α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

Human molecular genetics, 2006-10, Vol.15 (20), p.3012-3023

2006

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Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity

PLoS genetics, 2019-03, Vol.15 (3), p.e1008049-e1008049

2019

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MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples

Bioinformatics, 2014-03, Vol.30 (5), p.682-689

2014

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Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair

PloS one, 2014-10, Vol.9 (10), p.e110522-e110522

2014

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Weighted frequent gene co-expression network mining to identify genes involved in genome stability

PLoS computational biology, 2012-08, Vol.8 (8), p.e1002656-e1002656

2012

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Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells

PloS one, 2014-08, Vol.9 (8), p.e103819-e103819

2014

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Histone Deacetylases 9 and 10 Are Required for Homologous Recombination

The Journal of biological chemistry, 2011-03, Vol.286 (10), p.7722-7726

2011

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F-Box Protein-Mediated Resistance to PARP Inhibitor Therapy

Molecular cell, 2019-01, Vol.73 (2), p.195-196

2019

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Small Ubiquitin-like Modifier (SUMO) Isoforms and Conjugation-independent Function in DNA Double-strand Break Repair Pathways

The Journal of biological chemistry, 2014-08, Vol.289 (31), p.21289-21295

2014

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RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins

Nucleic acids research, 2016-03, Vol.44 (5), p.2136-2144

2016

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Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms

Genes chromosomes & cancer, 2017-08, Vol.56 (8), p.617-631

2017

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The functional impact of BRCA1 BRCT domain variants using multiplexed DNA double-strand break repair assays

American journal of human genetics, 2022-04, Vol.109 (4), p.618-630

2022

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HDAC10 as a potential therapeutic target in ovarian cancer

Gynecologic oncology, 2017-03, Vol.144 (3), p.613-620

2017

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Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes

Nucleic acids research, 2012-11, Vol.40 (20), p.10172-10186

2012

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BRCA1 contributes to transcription‐coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein

Cancer science, 2011-10, Vol.102 (10), p.1840-1847

2011

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Integrative analysis of somatic mutations and transcriptomic data to functionally stratify breast cancer patients

BMC genomics, 2016-08, Vol.17 Suppl 7 (Suppl 7), p.513-513, Article 513

2016

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BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number

Molecular and Cellular Biology, 2004-10, Vol.24 (19), p.8457-8466

2004

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BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (33), p.13558-13563

2013

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Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks

Human mutation, 2015-12, Vol.36 (12), p.1205-1214

2015

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The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing

Nucleic acids research, 2015-04, Vol.43 (7), p.3605-3613

2015

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DNA repair function scores for 2172 variants in the BRCA1 amino-terminus

A Multiplex Homology-Directed DNA Repair Assay Reveals the Impact of More Than 1,000 BRCA1 Missense Substitution Variants on Protein Function

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants

Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells

Multiplexed assay of variant effect reveals residues of functional importance in the BRCA1 coiled-coil and serine cluster domains

α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity

MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples

Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair

Weighted frequent gene co-expression network mining to identify genes involved in genome stability

Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells

Histone Deacetylases 9 and 10 Are Required for Homologous Recombination

F-Box Protein-Mediated Resistance to PARP Inhibitor Therapy

Small Ubiquitin-like Modifier (SUMO) Isoforms and Conjugation-independent Function in DNA Double-strand Break Repair Pathways

RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins

Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms

The functional impact of BRCA1 BRCT domain variants using multiplexed DNA double-strand break repair assays

HDAC10 as a potential therapeutic target in ovarian cancer

Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes

BRCA1 contributes to transcription‐coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein

Integrative analysis of somatic mutations and transcriptomic data to functionally stratify breast cancer patients

BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number

BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade

Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks

The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing

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