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Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts

Gastroenterology (New York, N.Y. 1943), 2021-10, Vol.161 (4), p.1179-1193

2021

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Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

PLoS biology, 2009-01, Vol.7 (1), p.e17

2009

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PKC and the control of localized signal dynamics

Nature reviews. Molecular cell biology, 2010-02, Vol.11 (2), p.103-112

2010

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14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

Cell, 2013-04, Vol.153 (3), p.640-653

2013

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EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

Nature communications, 2016-10, Vol.7 (1), p.13307-13307, Article 13307

2016

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HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer

PLoS biology, 2010-12, Vol.8 (12), p.e1000563-e1000563

2010

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Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways

Nature communications, 2014-05, Vol.5 (1), p.3907-3907, Article 3907

2014

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Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation

The Journal of cell biology, 2008-09, Vol.182 (5), p.855-863

2008

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Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes

Nature communications, 2016-06, Vol.7 (1), p.11942-18, Article 11942

2016

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Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration

PloS one, 2011-07, Vol.6 (7), p.e21732-e21732

2011

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aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization

Developmental cell, 2016-08, Vol.38 (4), p.384-398

2016

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A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapy

Biochemical Society transactions, 2014-08, Vol.42 (4), p.831-836

2014

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A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

Nature communications, 2021-11, Vol.12 (1), p.6934-6934, Article 6934

2021

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The late endosome is essential for mTORC1 signaling

Molecular biology of the cell, 2010-03, Vol.21 (5), p.833-841

2010

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The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers

Nature communications, 2018-10, Vol.9 (1), p.4325-17, Article 4325

2018

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A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

Nature communications, 2024-08, Vol.15 (1), p.7181-21

2024

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Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

Nature communications, 2024-03, Vol.15 (1), p.2130-2130, Article 2130

2024

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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

PLoS biology, 2007-04, Vol.5 (4), p.e95-791

2007

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Control of MT1-MMP transport by atypical PKC during breast-cancer progression

Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (18), p.E1872-E1879

2014

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A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

EMBO reports, 2008-02, Vol.9 (2), p.164-170

2008

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Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer

Cancer research (Chicago, Ill.), 2014-09, Vol.74 (17), p.4853-4863

2014

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Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Cell reports (Cambridge), 2016-01, Vol.14 (3), p.440-448

2016

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Effect of Phosphorylation on EGFR Dimer Stability Probed by Single-Molecule Dynamics and FRET/FLIM

Biophysical journal, 2015-03, Vol.108 (5), p.1013-1026

2015

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Editorial: Signaling by Small GTPases in Metastatic Disease

Frontiers in cell and developmental biology, 2022-01, Vol.10, p.841572-841572

2022

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PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways

PloS one, 2011-02, Vol.6 (2), p.e17168

2011

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Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts

Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

PKC and the control of localized signal dynamics

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer

Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways

Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation

Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes

Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration

aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization

A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapy

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

The late endosome is essential for mTORC1 signaling

The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers

A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

Control of MT1-MMP transport by atypical PKC during breast-cancer progression

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Effect of Phosphorylation on EGFR Dimer Stability Probed by Single-Molecule Dynamics and FRET/FLIM

Editorial: Signaling by Small GTPases in Metastatic Disease

PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways

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