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Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases

Frontiers in molecular biosciences, 2018-02, Vol.5, p.16

Palzkill, Timothy

2018

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Metallo-β-lactamase structure and function

Annals of the New York Academy of Sciences, 2013-01, Vol.1277 (1), p.91-104

Palzkill, Timothy

2013

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Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1

mBio, 2021-12, Vol.12 (6), p.e0277621

2021

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Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

Nature communications, 2018-10, Vol.9 (1), p.4524-14, Article 4524

2018

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The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium

PloS one, 2020-10, Vol.15 (10), p.e0240164

2020

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Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1

Cancer research (Chicago, Ill.), 2014-03, Vol.74 (5), p.1506-1517

2014

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Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1

Molecular endocrinology (Baltimore, Md.), 2011-12, Vol.25 (12), p.2041-2053

2011

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Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

Proceedings of the National Academy of Sciences - PNAS, 2016-05, Vol.113 (18), p.4970-4975

2016

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A Standard Numbering Scheme for Class C β-Lactamases

Antimicrobial agents and chemotherapy, 2020-02, Vol.64 (3)

2020

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PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates

Antimicrobial agents and chemotherapy, 2014-11, Vol.58 (11), p.6668-6674

2014

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How structural and physicochemical determinants shape sequence constraints in a functional enzyme

PloS one, 2015-02, Vol.10 (2), p.e0118684

2015

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An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes

Nature communications, 2022-11, Vol.13 (1), p.6726-6726, Article 6726

2022

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DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

Cell reports (Cambridge), 2019-12, Vol.29 (11), p.3448-3459.e6

2019

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Generation and characterization of antibodies against Asian elephant (Elephas maximus) IgG, IgM, and IgA

PloS one, 2015-02, Vol.10 (2), p.e0116318-e0116318

2015

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Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria

ACS sensors, 2017-09, Vol.2 (9), p.1257-1261

2017

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GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18261-18266

2014

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Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex In Vitro

mBio, 2019-02, Vol.10 (1)

2019

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Physiological roles of ArcA, Crp, and EtrA and their interactive control on aerobic and anaerobic respiration in Shewanella oneidensis

PloS one, 2010-12, Vol.5 (12), p.e15295

2010

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Characterization of cross-reactive norovirus-specific monoclonal antibodies

Clinical and vaccine immunology, 2015-02, Vol.22 (2), p.160-167

2015

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Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase

Communications biology, 2023-01, Vol.6 (1), p.35-35, Article 35

2023

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Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus

Journal of Virology, 2013-04, Vol.87 (8), p.4281-4292

2013

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Structural biology of MCR-1-mediated resistance to polymyxin antibiotics

Current opinion in structural biology, 2023-10, Vol.82, p.102647, Article 102647

2023

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Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response

npj vaccines, 2023-06, Vol.8 (1), p.87-87, Article 87

2023

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Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor

PloS one, 2014-04, Vol.9 (4), p.e95243

2014

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Probing the sites of interactions of rotaviral proteins involved in replication

Journal of virology, 2014-11, Vol.88 (21), p.12866-12881

2014

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Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases

Metallo-β-lactamase structure and function

Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1

Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium

Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1

Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1

Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

A Standard Numbering Scheme for Class C β-Lactamases

PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates

How structural and physicochemical determinants shape sequence constraints in a functional enzyme

An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

Generation and characterization of antibodies against Asian elephant (Elephas maximus) IgG, IgM, and IgA

Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria

GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex

Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex In Vitro

Physiological roles of ArcA, Crp, and EtrA and their interactive control on aerobic and anaerobic respiration in Shewanella oneidensis

Characterization of cross-reactive norovirus-specific monoclonal antibodies

Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase

Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus

Structural biology of MCR-1-mediated resistance to polymyxin antibiotics

Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response

Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor

Probing the sites of interactions of rotaviral proteins involved in replication

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