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Therapeutic disasters that hastened safety testing of new drugs

Clinical pharmacology and therapeutics, 2017-04, Vol.101 (4), p.430-434

Paine, MF

2017

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Evidence of CYP3A Allosterism In Vivo: Analysis of Interaction Between Fluconazole and Midazolam

Clinical pharmacology and therapeutics, 2012-03, Vol.91 (3), p.442-449

2012

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Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

Clinical pharmacology and therapeutics, 2015-04, Vol.97 (4), p.419-427

2015

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Movember Is Mustache Month

Clinical pharmacology and therapeutics, 2015-12, Vol.98 (6), p.562-564

2015

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Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions

Scientific reports, 2020-11, Vol.10 (1), p.19158, Article 19158

2020

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Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions

Drug metabolism and disposition, 1997-09, Vol.25 (9), p.1072

1997

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Comparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis‐generating Small Clinical Studies

Clinical and translational science, 2017-09, Vol.10 (5), p.380-386

2017

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The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

Drug metabolism reviews, 2001-01, Vol.33 (3-4), p.273-297

2001

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Quantitative prediction and clinical evaluation of an unexplored herb–drug interaction mechanism in healthy volunteers

CPT: pharmacometrics and systems pharmacology, 2015-12, Vol.4 (12), p.701-710

2015

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Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers

Gastroenterology (New York, N.Y. 1943), 1999-07, Vol.117 (1), p.89-98

1999

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Physiologically Based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction

CPT: pharmacometrics and systems pharmacology, 2014-03, Vol.3 (3), p.1-9

2014

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Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism

Clinical pharmacology and therapeutics, 1996-05, Vol.59 (5), p.491-502

1996

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First-pass metabolism of midazolam by the human intestine

Clinical pharmacology and therapeutics, 1996-07, Vol.60 (1), p.14-24

1996

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Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines

Pharmaceutical research, 1999-08, Vol.16 (8), p.1199-1205

1999

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Cytochrome P-450 1A1 expression in human small bowel: interindividual variation and inhibition by ketoconazole

Drug metabolism and disposition, 1999-03, Vol.27 (3), p.360

1999

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Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1552

1997

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Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins

Clinical pharmacology and therapeutics, 2001-01, Vol.69 (1), p.14-23

2001

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Molecular and physical mechanisms of first-pass extraction

Drug metabolism and disposition, 1999-02, Vol.27 (2), p.161

1999

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Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression?

Drug metabolism and disposition, 2005-03, Vol.33 (3), p.426

2005

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Effect of grapefruit juice on the disposition of omeprazole

British journal of clinical pharmacology, 2001-08, Vol.52 (2), p.216-217

2001

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Translational Medicine and Drug Discovery

Clinical pharmacology and therapeutics, 2011-09, Vol.90 (3), p.357-358

Paine, M F

2011

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Immunochemical Identification of UGT Isoforms in Human Small Bowel and in Caco-2 Cell Monolayers

Biochemical and biophysical research communications, 2000-07, Vol.273 (3), p.1053-1057

2000

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The human intestinal cytochrome P450 "pie"

Drug metabolism and disposition, 2006-05, Vol.34 (5), p.880

2006

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P-Glycoprotein increases from proximal to distal regions of human small intestine

Pharmaceutical research, 2003-10, Vol.20 (10), p.1595-1599

2003

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Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea ( Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation

Drug metabolism and disposition, 2018-05, Vol.46 (5), p.552-560

2018

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Therapeutic disasters that hastened safety testing of new drugs

Evidence of CYP3A Allosterism In Vivo: Analysis of Interaction Between Fluconazole and Midazolam

Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

Movember Is Mustache Month

Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions

Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions

Comparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis‐generating Small Clinical Studies

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

Quantitative prediction and clinical evaluation of an unexplored herb–drug interaction mechanism in healthy volunteers

Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers

Physiologically Based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism

First-pass metabolism of midazolam by the human intestine

Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines

Cytochrome P-450 1A1 expression in human small bowel: interindividual variation and inhibition by ketoconazole

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism

Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins

Molecular and physical mechanisms of first-pass extraction

Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression?

Effect of grapefruit juice on the disposition of omeprazole

Translational Medicine and Drug Discovery

Immunochemical Identification of UGT Isoforms in Human Small Bowel and in Caco-2 Cell Monolayers

The human intestinal cytochrome P450 "pie"

P-Glycoprotein increases from proximal to distal regions of human small intestine

Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea ( Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation

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