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Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (15), p.1874-1880

2019

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Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5′-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives

Acta crystallographica. Section D, Biological crystallography., 2011-01, Vol.67 (1), p.1-7

2011

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Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents

Bioorganic & medicinal chemistry, 2018-05, Vol.26 (9), p.2640-2650

2018

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Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants

Antimicrobial agents and chemotherapy, 2013-06, Vol.57 (6), p.2669-2677

2013

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Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4892-4902

2009

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Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase

Journal of structural biology, 2011-10, Vol.176 (1), p.52-59

2011

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Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase

Acta crystallographica. Section F, Structural biology communications, 2015-06, Vol.71 (6), p.799-803

2015

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New insights into DHFR interactions: Analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(ω-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions

Proteins, structure, function, and bioinformatics, 2006-12, Vol.65 (4), p.959-969

2006

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Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

Biochemistry (Easton), 2009-03, Vol.48 (8), p.1702-1711

2009

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Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3- d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

Bioorganic & medicinal chemistry, 2009-10, Vol.17 (20), p.7324-7336

2009

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Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2′-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode

Acta crystallographica. Section D, Biological crystallography., 2011-10, Vol.67 (10), p.875-880

2011

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Structural analysis of Pneumocystis carinii dihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine

Acta crystallographica. Section F, Structural biology and crystallization communications, 2012-04, Vol.68 (4), p.418-423

2012

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Structure-activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding

Acta crystallographica. Section D, Biological crystallography., 2012-12, Vol.68 (12), p.1604-1612

2012

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Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethyl-thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4892-4902

2009

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Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-ca rboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteri dine reveals an unusual binding mode

Acta crystallographica. Section D, Biological crystallography., 2011-10, Vol.67 (10), p.875-880

2011

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Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase

Acta crystallographica. Section D, Biological crystallography., 2010-12, Vol.66 (12), p.1271-1277

2010

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Strucutural and biochemical characterization of E. coli HinT and its H101A mutant

The FASEB journal, 2007-04, Vol.21 (5), p.A276-A276

2007

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Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2′-hydroxydibenz[b,f]azepin-5-yl)methylpteridine

Acta crystallographica. Section D, Biological crystallography., 2008-09, Vol.64 (9), p.977-984

2008

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The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex

Acta crystallographica. Section F, Structural biology and crystallization communications, 2009-08, Vol.65 (8), p.762-766

2009

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Structural analysis of Pneumocystis carinii dihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-meth y lpyrido[2,3-d]pyrimidine

Acta crystallographica. Section F, Structural biology and crystallization communications, 2012-04, Vol.68 (4), p.418-423

2012

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Strong evidence for terrestrial support of zooplankton in small lakes based on stable isotopes of carbon, nitrogen, and hydrogen

Proceedings of the National Academy of Sciences - PNAS, 2011-02, Vol.108 (5), p.1975-1980

2011

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Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study

American journal of respiratory and critical care medicine, 2018-12, Vol.198 (11), p.1397-1405

2018

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Gene.iobio: an interactive web tool for versatile, clinically-driven variant interrogation and prioritization

Scientific reports, 2021-10, Vol.11 (1), p.20307-11, Article 20307

2021

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Author Correction: Gene.iobio: an interactive web tool for versatile, clinically-driven variant interrogation and prioritization

Scientific reports, 2022-04, Vol.12 (1), p.5800-5800, Article 5800

2022

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Resting-state EEG correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study

Neurobiology of aging, 2024-12, Vol.144, p.68-77

2024

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Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5′-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives

Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents

Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants

Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase

Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase

New insights into DHFR interactions: Analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(ω-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions

Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3- d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2′-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode

Structural analysis of Pneumocystis carinii dihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine

Structure-activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding

Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethyl-thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-ca rboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteri dine reveals an unusual binding mode

Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase

Strucutural and biochemical characterization of E. coli HinT and its H101A mutant

Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2′-hydroxydibenz[b,f]azepin-5-yl)methylpteridine

The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex

Structural analysis of Pneumocystis carinii dihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-meth y lpyrido[2,3-d]pyrimidine

Strong evidence for terrestrial support of zooplankton in small lakes based on stable isotopes of carbon, nitrogen, and hydrogen

Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study

Gene.iobio: an interactive web tool for versatile, clinically-driven variant interrogation and prioritization

Author Correction: Gene.iobio: an interactive web tool for versatile, clinically-driven variant interrogation and prioritization

Resting-state EEG correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study

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