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Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1

Science signaling, 2013-05, Vol.6 (277), p.ra42

2013

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Spatially Distinct Pools of TORC1 Balance Protein Homeostasis

Molecular cell, 2019-01, Vol.73 (2), p.325-338.e8

2019

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The Vam6 GEF Controls TORC1 by Activating the EGO Complex

Molecular cell, 2009-09, Vol.35 (5), p.563-573

2009

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Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

Cell reports (Cambridge), 2015-10, Vol.13 (1), p.1-7

2015

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The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis

Journal of cell science, 2015-07, Vol.128 (13), p.2278-2292

2015

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Ego3 Functions as a Homodimer to Mediate the Interaction between Gtr1-Gtr2 and Ego1 in the EGO Complex to Activate TORC1

Structure (London), 2012-12, Vol.20 (12), p.2151-2160

2012

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Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals

Cell reports (Cambridge), 2017-07, Vol.20 (2), p.281-288

2017

Volltextzugriff (PDF)

SEACing the GAP that nEGOCiates TORC1 activation: Evolutionary conservation of Rag GTPase regulation

Cell cycle (Georgetown, Tex.), 2013-09, Vol.12 (18), p.2948-2952

2013

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The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity

The Journal of cell biology, 2022-05, Vol.221 (5), p.1

2022

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TORC1 Determines Fab1 Lipid Kinase Function at Signaling Endosomes and Vacuoles

Current biology, 2021-01, Vol.31 (2), p.297-309.e8

2021

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TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1

Cell discovery, 2017-05, Vol.3 (1), p.17012-17012, Article 17012

2017

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An EGOcentric view of TORC1 signaling

Cell cycle (Georgetown, Tex.), 2010-01, Vol.9 (2), p.221-222

2010

Volltextzugriff (PDF)

Identification of a Small Molecule Yeast TORC1 Inhibitor with a Multiplex Screen Based on Flow Cytometry

ACS chemical biology, 2012-04, Vol.7 (4), p.715-722

2012

Volltextzugriff (PDF)

Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases

Science advances, 2019-09, Vol.5 (9), p.eaax8164-eaax8164

2019

Volltextzugriff (PDF)

Manganese is a physiologically relevant TORC1 activator in yeast and mammals

eLife, 2022-07, Vol.11

2022

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The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities

Molecular and biochemical parasitology, 2009-04, Vol.164 (2), p.147-152

2009

Volltextzugriff (PDF)

Phosphorylation State Defines Discrete Roles for Monopolin in Chromosome Attachment and Spindle Elongation

Current biology, 2009-06, Vol.19 (12), p.985-995

2009

Volltextzugriff (PDF)

S. pombe FEAR protein orthologs are not required for release of Clp1/Flp1 phosphatase from the nucleolus during mitosis

Journal of cell science, 2006-11, Vol.119 (21), p.4462-4466

2006

Volltextzugriff (PDF)

A phosphorylation dependent switch defines discrete roles for the monopolin complex in chromosome attachment and spindle elongation

Current biology, 2009-06, Vol.19 (12), p.985-995

2009

Volltextzugriff (PDF)

Identification of a small molecule yeast TORC1 inhibitor with a flow cytometry-based multiplex screen

ACS chemical biology, 2012-02, Vol.7 (4), p.715-722

2012

Volltextzugriff (PDF)

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Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis

Ego3 Functions as a Homodimer to Mediate the Interaction between Gtr1-Gtr2 and Ego1 in the EGO Complex to Activate TORC1

Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals

SEACing the GAP that nEGOCiates TORC1 activation: Evolutionary conservation of Rag GTPase regulation

The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity

TORC1 Determines Fab1 Lipid Kinase Function at Signaling Endosomes and Vacuoles

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1

An EGOcentric view of TORC1 signaling

Identification of a Small Molecule Yeast TORC1 Inhibitor with a Multiplex Screen Based on Flow Cytometry

Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases

Manganese is a physiologically relevant TORC1 activator in yeast and mammals

The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities

Phosphorylation State Defines Discrete Roles for Monopolin in Chromosome Attachment and Spindle Elongation

S. pombe FEAR protein orthologs are not required for release of Clp1/Flp1 phosphatase from the nucleolus during mitosis

A phosphorylation dependent switch defines discrete roles for the monopolin complex in chromosome attachment and spindle elongation

Identification of a small molecule yeast TORC1 inhibitor with a flow cytometry-based multiplex screen

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