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Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Nature (London), 2013-07, Vol.499 (7456), p.97-101

2013

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Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

eLife, 2019-12, Vol.8

2019

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The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion

Biochemical and biophysical research communications, 2022-06, Vol.611, p.165-171

2022

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Methylmercury-induced brain neuronal death in CHOP-knockout mice

The Journal of Toxicological Sciences, 2024, Vol.49(2), pp.55-60

2024

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Effective three‐dimensional culture of hepatocyte‐like cells generated from human adipose‐derived mesenchymal stem cells

Journal of hepato-biliary-pancreatic sciences, 2021-09, Vol.28 (9), p.705-715

2021

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Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation

PloS one, 2020-03, Vol.15 (3), p.e0229948-e0229948

2020

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ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity

Cell reports (Cambridge), 2017-02, Vol.18 (8), p.2045-2057

2017

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A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition

Scientific reports, 2021-02, Vol.11 (1), p.4538-14, Article 4538

2021

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

Genes & development, 2004-12, Vol.18 (24), p.3066-3077

2004

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The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity

Scientific reports, 2021-06, Vol.11 (1), p.13086-13086, Article 13086

2021

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A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning

Nature communications, 2017-12, Vol.8 (1), p.2079-19, Article 2079

2017

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Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity

iScience, 2021-12, Vol.24 (12), p.103448-103448, Article 103448

2021

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Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice

PloS one, 2017-06, Vol.12 (6), p.e0179955-e0179955

2017

Volltextzugriff (PDF)

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes

International journal of molecular sciences, 2019-04, Vol.20 (7), p.1706

2019

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The C-terminal region including the MH6 domain of Msx1 regulates skeletal development

Biochemical and biophysical research communications, 2020-05, Vol.526 (1), p.62-69

2020

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Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo

Proceedings of the National Academy of Sciences - PNAS, 2022-10, Vol.119 (40), p.e2203307119-e2203307119

2022

Volltextzugriff (PDF)

ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model

Molecular metabolism (Germany), 2021-12, Vol.54, p.101338-101338, Article 101338

2021

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Cotranslocational Degradation Protects the Stressed Endoplasmic Reticulum from Protein Overload

Cell, 2006-08, Vol.126 (4), p.727-739

2006

Volltextzugriff (PDF)

The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice

Journal of Atherosclerosis and Thrombosis, 2017/12/01, Vol.24(12), pp.1215-1230

2017

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Palmitate-Stimulated Monocytes Induce Adhesion Molecule Expression in Endothelial Cells via IL-1 Signaling Pathway

Journal of cellular physiology, 2015-03, Vol.230 (3), p.732-742

2015

Volltextzugriff (PDF)

Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung

PloS one, 2020-10, Vol.15 (10), p.e0240333-e0240333

2020

Volltextzugriff (PDF)

Growth arrest and DNA damage‐inducible 34 regulates liver regeneration in hepatic steatosis in mice

Hepatology (Baltimore, Md.), 2015-04, Vol.61 (4), p.1343-1356

2015

Volltextzugriff (PDF)

Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos

Scientific reports, 2017-03, Vol.7 (1), p.53-10, Article 53

2017

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Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development

Genes, 2023-01, Vol.14 (2), p.340

2023

Volltextzugriff (PDF)

Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland

Acta medica Okayama, 2020-06, Vol.74 (3), p.199-208

2020

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Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion

Methylmercury-induced brain neuronal death in CHOP-knockout mice

Effective three‐dimensional culture of hepatocyte‐like cells generated from human adipose‐derived mesenchymal stem cells

Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation

ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity

A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity

A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning

Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity

Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice

Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes

The C-terminal region including the MH6 domain of Msx1 regulates skeletal development

Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo

ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model

Cotranslocational Degradation Protects the Stressed Endoplasmic Reticulum from Protein Overload

The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice

Palmitate-Stimulated Monocytes Induce Adhesion Molecule Expression in Endothelial Cells via IL-1 Signaling Pathway

Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung

Growth arrest and DNA damage‐inducible 34 regulates liver regeneration in hepatic steatosis in mice

Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos

Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development

Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland

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