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An analysis of the attrition of drug candidates from four major pharmaceutical companies

Nature reviews. Drug discovery, 2015-07, Vol.14 (7), p.475-486

2015

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Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions

ACS chemical biology, 2007-02, Vol.2 (2), p.119-127

2007

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Managing COVID-19 from the epicenter: adaptations and suggestions based on experience

Journal of anesthesia, 2021-06, Vol.35 (3), p.366-373

2021

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Mobitz II Second-Degree Heart Block During Total Hip Arthroplasty: ACase Report

Heliyon, 2024-03, Vol.10 (6), p.e27486, Article e27486

2024

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Stereoselective Synthesis of the C(1)−C(11) Fragment of Peloruside A

Organic letters, 2005-09, Vol.7 (18), p.3941-3944

2005

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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.593-624

2013

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Synthesis and Applications of End-Labeled Neoglycopolymers

Organic letters, 2002-07, Vol.4 (14), p.2293-2296

2002

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Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865)

Journal of medicinal chemistry, 2019-06, Vol.62 (12), p.5773-5796

2019

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The Pfizer Crystal Structure Database: An essential tool for structure‐based design at Pfizer

Journal of computational chemistry, 2022-06, Vol.43 (15), p.1053-1062

2022

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Design and Identification of a Novel, Functionally Subtype Selective GABA A Positive Allosteric Modulator (PF-06372865)

Journal of medicinal chemistry, 2019-06, Vol.62 (12), p.5773, Article acs.jmedchem.9b00322

2019

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The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout

MedChemComm, 2016-01, Vol.7 (8), p.1572-1579

2016

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Voltage gated sodium channels as drug discovery targets

Channels (Austin, Tex.), 2015-11, Vol.9 (6), p.360-366

2015

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Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ‑Opioid Receptor

Journal of chemical information and modeling, 2021-07, Vol.61 (7), p.3696-3707

2021

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Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF‐06372865

British journal of pharmacology, 2018-02, Vol.175 (4), p.708-725

2018

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The Latest Miocene–Early Pliocene biogenic bloom: a revised Indian Ocean perspective

Marine geology, 1999-09, Vol.161 (1), p.75-91

1999

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The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights from 2021

Journal of cardiothoracic and vascular anesthesia, 2022-04, Vol.36 (4), p.940-951

2022

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Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

ACS medicinal chemistry letters, 2015-04, Vol.6 (4), p.419-424

2015

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5-(2-Pyrimidinyl)-imidazo[1,2- a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (18), p.5302-5306

2009

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Analysis of Differential Efficacy and Affinity of GABAA (α1/α2) Selective Modulators

Molecular pharmaceutics, 2016-11, Vol.13 (11), p.4001-4012

2016

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Targeting the cAMP and Transforming Growth Factor‐β Pathway Increases Proliferation to Promote Re‐Epithelialization of Human Stem Cell‐Derived Retinal Pigment Epithelium

Stem cells translational medicine, 2016-07, Vol.5 (7), p.925-937

2016

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Analysis of Differential Efficacy and Affinity of GABA A (α1/α2) Selective Modulators

Molecular pharmaceutics, 2016-11, Vol.13 (11), p.4001-4012

2016

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Conserved Amplification of Chemotactic Responses through Chemoreceptor Interactions

Journal of Bacteriology, 2002-09, Vol.184 (18), p.4981-4987

2002

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The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout

MedChemComm, 2016-01, Vol.7 (8), p.1587-1595

2016

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Selective Immobilization of Multivalent Ligands for Surface Plasmon Resonance and Fluorescence Microscopy

Analytical biochemistry, 2002-06, Vol.305 (2), p.149-155

2002

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The rare earth element geochemistry of hydrothermal sediments from the East Pacific Rise: Examination of a seawater scavenging mechanism

Geochimica et cosmochimica acta, 1986-03, Vol.50 (3), p.393-400

1986

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An analysis of the attrition of drug candidates from four major pharmaceutical companies

Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions

Managing COVID-19 from the epicenter: adaptations and suggestions based on experience

Mobitz II Second-Degree Heart Block During Total Hip Arthroplasty: ACase Report

Stereoselective Synthesis of the C(1)−C(11) Fragment of Peloruside A

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

Synthesis and Applications of End-Labeled Neoglycopolymers

Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865)

The Pfizer Crystal Structure Database: An essential tool for structure‐based design at Pfizer

Design and Identification of a Novel, Functionally Subtype Selective GABA A Positive Allosteric Modulator (PF-06372865)

The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout

Voltage gated sodium channels as drug discovery targets

Delineating the Ligand–Receptor Interactions That Lead to Biased Signaling at the μ‑Opioid Receptor

Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF‐06372865

The Latest Miocene–Early Pliocene biogenic bloom: a revised Indian Ocean perspective

The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights from 2021

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

5-(2-Pyrimidinyl)-imidazo[1,2- a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV

Analysis of Differential Efficacy and Affinity of GABAA (α1/α2) Selective Modulators

Targeting the cAMP and Transforming Growth Factor‐β Pathway Increases Proliferation to Promote Re‐Epithelialization of Human Stem Cell‐Derived Retinal Pigment Epithelium

Analysis of Differential Efficacy and Affinity of GABA A (α1/α2) Selective Modulators

Conserved Amplification of Chemotactic Responses through Chemoreceptor Interactions

The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout

Selective Immobilization of Multivalent Ligands for Surface Plasmon Resonance and Fluorescence Microscopy

The rare earth element geochemistry of hydrothermal sediments from the East Pacific Rise: Examination of a seawater scavenging mechanism

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