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Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

Biochemical pharmacology, 2014-04, Vol.88 (4), p.508-516

2014

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

Nature reviews. Neuroscience, 2013-01, Vol.14 (1), p.38-48

2013

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Toward a unified therapeutics approach targeting putative amyloid-β oligomer receptors

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.13680-13681

2014

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A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies

PloS one, 2015-03, Vol.10 (3), p.e0121570-e0121570

2015

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Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice

Neurobiology of disease, 2012-01, Vol.45 (1), p.479-487

2012

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Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease

Neurobiology of disease, 2009-09, Vol.35 (3), p.415-425

2009

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Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

Brain (London, England : 1878), 2014-05, Vol.137 (5), p.1496-1513

2014

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In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin

Chemico-biological interactions, 2008-10, Vol.176 (1), p.30-39

2008

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A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease

Brain (London, England : 1878), 2016-12, Vol.139 (Pt 12), p.3217-3236

2016

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A novel approach for long-term oral drug administration in animal research

Journal of neuroscience methods, 2011-02, Vol.195 (2), p.194-199

2011

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Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model

The Journal of neuroscience, 2016-07, Vol.36 (30), p.7971-7984

2016

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Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies

Molecular neurodegeneration, 2014-05, Vol.9 (1), p.18-18, Article 18

2014

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Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators

Drug metabolism and disposition, 2009-01, Vol.37 (1), p.161

2009

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Structure-Activity Relationships for a Family of Benzothiophene Selective Estrogen Receptor Modulators Including Raloxifene and Arzoxifene

ChemMedChem, 2007-10, Vol.2 (10), p.1520-1526

2007

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Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms

Molecular cancer therapeutics, 2007-09, Vol.6 (9), p.2418-2428

2007

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Neuroprotective effects of the anti‐cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders

British journal of pharmacology, 2014-12, Vol.171 (24), p.5757-5773

2014

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Sex Steroid Levels and AD-Like Pathology in 3xTgAD Mice

Journal of neuroendocrinology, 2013-02, Vol.25 (2), p.131-144

2013

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Seasonal Variation of Red Clover (Trifolium pratense L., Fabaceae) Isoflavones and Estrogenic Activity

Journal of agricultural and food chemistry, 2006-02, Vol.54 (4), p.1277-1282

2006

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Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation

Journal of Alzheimer's disease, 2014-01, Vol.39 (3), p.583

2014

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Comparison of the in Vitro Estrogenic Activities of Compounds from Hops (Humulus lupulus) and Red Clover (Trifolium pratense)

Journal of agricultural and food chemistry, 2005-08, Vol.53 (16), p.6246-6253

2005

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Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AβPPswe/PS1ΔE9 mice

Journal of Alzheimer's disease, 2011-01, Vol.25 (3), p.491

2011

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Estrogens and Congeners from Spent Hops (Humulus l upulus)

Journal of natural products (Washington, D.C.), 2004-12, Vol.67 (12), p.2024-2032

2004

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Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease

Journal of chemical neuroanatomy, 2010-09, Vol.40 (1), p.63-70

2010

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High-content screening and mechanism-based evaluation of estrogenic botanical extracts

Combinatorial chemistry & high throughput screening, 2008-05, Vol.11 (4), p.283

2008

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Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506

Neuroscience, 2015-12, Vol.310, p.549-560

2015

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Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

The many faces of α-synuclein: from structure and toxicity to therapeutic target

Toward a unified therapeutics approach targeting putative amyloid-β oligomer receptors

A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies

Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice

Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin

A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease

A novel approach for long-term oral drug administration in animal research

Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model

Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies

Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators

Structure-Activity Relationships for a Family of Benzothiophene Selective Estrogen Receptor Modulators Including Raloxifene and Arzoxifene

Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms

Neuroprotective effects of the anti‐cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders

Sex Steroid Levels and AD-Like Pathology in 3xTgAD Mice

Seasonal Variation of Red Clover (Trifolium pratense L., Fabaceae) Isoflavones and Estrogenic Activity

Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation

Comparison of the in Vitro Estrogenic Activities of Compounds from Hops (Humulus lupulus) and Red Clover (Trifolium pratense)

Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AβPPswe/PS1ΔE9 mice

Estrogens and Congeners from Spent Hops (Humulus l upulus)

Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease

High-content screening and mechanism-based evaluation of estrogenic botanical extracts

Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506

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