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Distribution of FcRn Across Species and Tissues

The journal of histochemistry and cytochemistry, 2017-06, Vol.65 (6), p.321-333

2017

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Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies

PloS one, 2018-10, Vol.13 (10), p.e0205435-e0205435

2018

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Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2853-2859

2017

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Quantification of IgG monoclonal antibody clearance in tissues

mAbs, 2017-08, Vol.9 (6), p.1007-1015

2017

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Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration

Frontiers in pharmacology, 2022-08, Vol.13, p.958543-958543

2022

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Interstitial IgG antibody pharmacokinetics assessed by combined in vivo‐ and physiologically‐based pharmacokinetic modelling approaches

The Journal of physiology, 2017-12, Vol.595 (24), p.7311-7330

2017

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Pharmacokinetics and Determination of Tumor Interstitial Distribution of a Therapeutic Monoclonal Antibody Using Large-Pore Microdialysis

Journal of pharmaceutical sciences, 2021-08, Vol.110 (8), p.3061-3068

2021

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Biodistribution of Drug/ADA Complexes: The Impact of Immune Complex Formation on Antibody Distribution

The AAPS journal, 2024-03, Vol.26 (2), p.33-33, Article 33

2024

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Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach

Pharmaceutical research, 2016-10, Vol.33 (10), p.2565-2579

2016

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“Catch-and-Release” Anti-Carcinoembryonic Antigen Monoclonal Antibody Leads to Greater Plasma and Tumor Exposure in a Mouse Model of Colorectal Cancer

The Journal of pharmacology and experimental therapeutics, 2018-07, Vol.366 (1), p.205-219

2018

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Radiolabeled IgG antibodies: Impact of various labels on neonatal Fc receptor binding

Journal of labelled compounds & radiopharmaceuticals, 2019-09, Vol.62 (11), p.751-757

2019

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High-Throughput, Sensitive LC-MS Quantification of Biotherapeutics and Biomarkers Using Antibody-Free, Peptide-Level, Multiple-Mechanism Enrichment via Strategic Regulation of pH and Ionic and Solvent Strengths

Analytical chemistry (Washington), 2019-03, Vol.91 (5), p.3475-3483

2019

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The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance

mAbs, 2021-01, Vol.13 (1), p.1995929-1995929

2021

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Erratum to: Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach

Pharmaceutical research, 2016-11, Vol.33 (11), p.2844-2844

2016

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Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms

mAbs, 2017-07, Vol.9 (5), p.781-791

2017

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Nonclinical Pharmacokinetics of Oseltamivir and Oseltamivir Carboxylate in the Central Nervous System

Antimicrobial Agents and Chemotherapy, 2009-11, Vol.53 (11), p.4753-4761

2009

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Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies

Drug metabolism and disposition, 2012-08, Vol.40 (8), p.1556-1565

2012

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In vivo Oxidative Metabolism of a Major Peroxidation-Derived DNA Adduct, M₁dG

Proceedings of the National Academy of Sciences - PNAS, 2006-04, Vol.103 (17), p.6665-6669

2006

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Discovery of a factor Xa inhibitor (3 R,4 R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (17), p.5313-5319

2010

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Biological Characterization of Novel Inhibitors of the Gram-Positive DNA Polymerase IIIC Enzyme

Antimicrobial Agents and Chemotherapy, 2005-03, Vol.49 (3), p.987-995

2005

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Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts

Mutation research, 1999-03, Vol.424 (1), p.237-247

1999

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Measurement of the malondialdehyde-2′-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

Journal of mass spectrometry., 2004-01, Vol.39 (1), p.38-42

2004

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32P-Postlabeling Analysis of DNA Adducts of Styrene 7,8-Oxide at the O6-Position of Guanine

Chemical research in toxicology, 1999-01, Vol.12 (1), p.93-99

1999

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Reactivity and mutagenicity of endogenous DNA oxopropenylating agents: base propenals, malondialdehyde, and N(epsilon)-oxopropenyllysine

Chemical research in toxicology, 2000-12, Vol.13 (12), p.1235

2000

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Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: Optimization of in vitro activity

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5426-5430

2010

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Distribution of FcRn Across Species and Tissues

Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies

Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis

Quantification of IgG monoclonal antibody clearance in tissues

Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration

Interstitial IgG antibody pharmacokinetics assessed by combined in vivo‐ and physiologically‐based pharmacokinetic modelling approaches

Pharmacokinetics and Determination of Tumor Interstitial Distribution of a Therapeutic Monoclonal Antibody Using Large-Pore Microdialysis

Biodistribution of Drug/ADA Complexes: The Impact of Immune Complex Formation on Antibody Distribution

Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach

“Catch-and-Release” Anti-Carcinoembryonic Antigen Monoclonal Antibody Leads to Greater Plasma and Tumor Exposure in a Mouse Model of Colorectal Cancer

Radiolabeled IgG antibodies: Impact of various labels on neonatal Fc receptor binding

High-Throughput, Sensitive LC-MS Quantification of Biotherapeutics and Biomarkers Using Antibody-Free, Peptide-Level, Multiple-Mechanism Enrichment via Strategic Regulation of pH and Ionic and Solvent Strengths

The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance

Erratum to: Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach

Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms

Nonclinical Pharmacokinetics of Oseltamivir and Oseltamivir Carboxylate in the Central Nervous System

Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies

In vivo Oxidative Metabolism of a Major Peroxidation-Derived DNA Adduct, M₁dG

Discovery of a factor Xa inhibitor (3 R,4 R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate

Biological Characterization of Novel Inhibitors of the Gram-Positive DNA Polymerase IIIC Enzyme

Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts

Measurement of the malondialdehyde-2′-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

32P-Postlabeling Analysis of DNA Adducts of Styrene 7,8-Oxide at the O6-Position of Guanine

Reactivity and mutagenicity of endogenous DNA oxopropenylating agents: base propenals, malondialdehyde, and N(epsilon)-oxopropenyllysine

Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: Optimization of in vitro activity

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