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An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

Cell, 2020-06, Vol.181 (6), p.1410-1422.e27

2020

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Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

Cell reports (Cambridge), 2018-11, Vol.25 (9), p.2308-2316.e4

2018

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Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

Cell stem cell, 2020-10, Vol.27 (4), p.590-604.e9

2020

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Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

Nature medicine, 2019-03, Vol.25 (3), p.423-426

2019

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Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

American journal of human genetics, 2011-05, Vol.88 (5), p.650-656

2011

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Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

Journal of cellular physiology, 2015-01, Vol.230 (1), p.191-198

2015

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Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (37), p.16268-16273

2010

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Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver

Aging cell, 2018-06, Vol.17 (3), p.e12742-n/a

2018

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Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling

Nature medicine, 2016-01, Vol.22 (1), p.91-96

2016

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Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

Nature communications, 2013-08, Vol.4 (1), p.2268-2268, Article 2268

2013

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Lifelong multilineage contribution by embryonic-born blood progenitors

Nature (London), 2022-06, Vol.606 (7915), p.747-753

2022

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Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment

Circulation (New York, N.Y.), 2013-06, Vol.127 (24), p.2442-2451

2013

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Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

BMC cancer, 2011-05, Vol.11 (1), p.172-172, Article 172

2011

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Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

Genes & development, 2012-10, Vol.26 (20), p.2311-2324

2012

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An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

Cell, 2020-06, Vol.181 (7), p.1693-1694

2020

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Splicing-directed therapy in a new mouse model of human accelerated aging

Science translational medicine, 2011-10, Vol.3 (106), p.106ra107

2011

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NF-κB activation impairs somatic cell reprogramming in ageing

Nature cell biology, 2015-08, Vol.17 (8), p.1004

2015

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Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

The EMBO journal, 2015-07, Vol.34 (14), p.1875-1888

2015

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Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

Nature Medicine, 2008-07, Vol.14 (7), p.767-772

2008

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Immune and inflammatory responses to DNA damage in cancer and aging

Mechanisms of ageing and development, 2017-07, Vol.165 (Pt A), p.10-16

2017

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Reprogramming aging through DOT1L inhibition

Cell cycle (Georgetown, Tex.), 2015-11, Vol.14 (21), p.3345-3346

2015

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Identification of mitochondrial dysfunction in Hutchinson–Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture

Journal of proteomics, 2013-10, Vol.91, p.466-477

2013

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Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation

Science signaling, 2014-04, Vol.7 (322), p.ra37

2014

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MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling

The Journal of immunology (1950), 2016-07, Vol.197 (1), p.296-302

2016

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Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (46), p.E7250-E7259

2016

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An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

Lifelong multilineage contribution by embryonic-born blood progenitors

Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment

Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

Splicing-directed therapy in a new mouse model of human accelerated aging

NF-κB activation impairs somatic cell reprogramming in ageing

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

Immune and inflammatory responses to DNA damage in cancer and aging

Reprogramming aging through DOT1L inhibition

Identification of mitochondrial dysfunction in Hutchinson–Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture

Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation

MMP-25 Metalloprotease Regulates Innate Immune Response through NF-κB Signaling

Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations

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