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MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (9), p.3507-3512

2009

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Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5962), p.198-201

2010

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MicroRNAs in Liver Disease

Gastroenterology (New York, N.Y. 1943), 2012-06, Vol.142 (7), p.1431-1443

2012

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Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

Nucleic acids research, 2010-01, Vol.38 (1), p.e3

2010

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A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth

Molecular cancer therapeutics, 2008-11, Vol.7 (11), p.3598-3608

2008

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A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo

PloS one, 2010-05, Vol.5 (5), p.e10682

2010

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Antisense‐mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first‐in‐human randomized, placebo‐controlled trial

British journal of clinical pharmacology, 2015-12, Vol.80 (6), p.1350-1361

2015

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Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

Nucleic acids research, 2010-11, Vol.38 (20), p.7100

2010

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PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates

Molecular therapy, 2012-02, Vol.20 (2), p.376-381

2012

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Locked nucleic acid holds promise in the treatment of cancer

Current pharmaceutical design, 2008-04, Vol.14 (11), p.1138

2008

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Electronic Structures of LNA Phosphorothioate Oligonucleotides

Molecular therapy. Nucleic acids, 2017-09, Vol.8, p.428-441

2017

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Efficient and Persistent Splice Switching by Systemically Delivered LNA Oligonucleotides in Mice

Molecular therapy, 2006-10, Vol.14 (4), p.471-475

2006

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SPC3042: a proapoptotic survivin inhibitor

Molecular cancer therapeutics, 2008-09, Vol.7 (9), p.2736-2745

2008

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Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern

Nucleic acid therapeutics, 2013-10, Vol.23 (5), p.302

2013

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A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys

Nucleic acid therapeutics, 2012-06, Vol.22 (3), p.152

2012

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Quantum mechanical studies of DNA and LNA

Nucleic acid therapeutics, 2014-04, Vol.24 (2), p.139

2014

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An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models

Molecular therapy, 2008-07, Vol.16 (7), p.1316-1322

2008

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Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis

The American journal of pathology, 2010-12, Vol.177 (6), p.3010-3024

2010

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Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA

Nucleic acids research, 2003-11, Vol.31 (21), p.6365

2003

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The application of locked nucleic acids in the treatment of cancer

IDrugs : the investigational drugs journal, 2006-10, Vol.9 (10), p.706

2006

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Aptamers Targeted to an RNA Hairpin Show Improved Specificity Compared to that of Complementary Oligonucleotides

Biochemistry (Easton), 2006-10, Vol.45 (39), p.12076-12082

2006

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LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1

Nucleic acids research, 2004, Vol.32 (10), p.3101

2004

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Detection of the Factor V Leiden Mutation by Direct Allele-specific Hybridization of PCR Amplicons to Photoimmobilized Locked Nucleic Acids

Clinical chemistry (Baltimore, Md.), 1999-11, Vol.45 (11), p.1898-1905

1999

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Single base pair mutation analysis by PNA directed PCR clamping

Nucleic acids research, 1993-11, Vol.21 (23), p.5332-5336

1993

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Peptide Nucleic Acid-DNA Duplexes: Long Range Hole Migration from an Internally Linked Anthraquinone

Proceedings of the National Academy of Sciences - PNAS, 1997-11, Vol.94 (23), p.12320-12325

1997

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MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

MicroRNAs in Liver Disease

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo

Antisense‐mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first‐in‐human randomized, placebo‐controlled trial

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates

Locked nucleic acid holds promise in the treatment of cancer

Electronic Structures of LNA Phosphorothioate Oligonucleotides

Efficient and Persistent Splice Switching by Systemically Delivered LNA Oligonucleotides in Mice

SPC3042: a proapoptotic survivin inhibitor

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern

A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys

Quantum mechanical studies of DNA and LNA

An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models

Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA

The application of locked nucleic acids in the treatment of cancer

Aptamers Targeted to an RNA Hairpin Show Improved Specificity Compared to that of Complementary Oligonucleotides

LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1

Detection of the Factor V Leiden Mutation by Direct Allele-specific Hybridization of PCR Amplicons to Photoimmobilized Locked Nucleic Acids

Single base pair mutation analysis by PNA directed PCR clamping

Peptide Nucleic Acid-DNA Duplexes: Long Range Hole Migration from an Internally Linked Anthraquinone

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