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Abstract 4522: Potent induction of a tumor-specific immune response by a cyclic dinucleotide STING agonist

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.4522-4522

2020

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Bis(guanidinium) Receptors as Ribonuclease Active-Site Model Systems: Structural Changes and Solvent Effects

Liebigs Annalen, 1997-05, Vol.1997 (5), p.1005-1011

1997

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Design and synthesis of substrate-based inhibitors of botulinum neurotoxin type B metalloprotease

Biopolymers, 2003, Vol.71 (6), p.602-619

2003

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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3264-3269

2015

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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3270-3274

2015

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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part III: Discovery of pre-clinical development candidate BI 186908

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3275-3280

2015

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Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.1165-1181

2006

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Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6587-6591

2010

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Discovery of Aminoglycoside Mimetics by NMR-Based Screening of Escherichia c oli A-site RNA

Journal of the American Chemical Society, 2003-04, Vol.125 (15), p.4444-4450

2003

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Discovery of Aminoglycoside Mimetics by NMR-Based Screening of Escherichia coli A-site RNA

Journal of the American Chemical Society, 2003-04, Vol.125 (15), p.4444-4450

2003

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Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9376-9400

2023

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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Journal of medicinal chemistry, 2004-08, Vol.47 (18), p.4417-4426

2004

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Inhibitors of Anti-apoptotic Proteins for Cancer Therapy

Annual Reports in Medicinal Chemistry, 2005, Vol.40, p.245-262

2005

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Managing erosion of mangrove-mud coasts with permeable dams – lessons learned

Ecological engineering, 2020-12, Vol.158, p.106078, Article 106078

2020

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Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists

Bioorganic & medicinal chemistry letters, 2018-10, Vol.28 (19), p.3260-3264

2018

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Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3828-3831

2011

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Potent, selective inhibitors of protein tyrosine phosphatase 1B

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1887-1890

2003

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Regio- and diastereo-selectivity of the insertion of aldehydes into alkyne zirconocene complexes

Journal of organometallic chemistry, 1995-12, Vol.505 (1), p.95-107

1995

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Sequencing Hydroxyethylamine-Containing Peptides via Edman Degradation

Organic letters, 2002-10, Vol.4 (20), p.3469-3472

2002

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Structural Basis for BABIM Inhibition of Botulinum Neurotoxin Type B Protease

Journal of the American Chemical Society, 2000-11, Vol.122 (45), p.11268-11269

2000

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Structural Basis for BABIM Inhibition of Botulinum Neurotoxin Type B Protease [J. Am. Chem. Soc. 2000, 122, 11268−11269]

Journal of the American Chemical Society, 2002-08, Vol.124 (34), p.10248-10248

2002

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Nature (London), 2000-12, Vol.408 (6815), p.1004-1008

2000

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Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.641-662

2007

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Synthesis of RNAse active site model systems using a steroid template

Tetrahedron, 1997-06, Vol.53 (25), p.8421-8438

1997

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Abstract 4522: Potent induction of a tumor-specific immune response by a cyclic dinucleotide STING agonist

Bis(guanidinium) Receptors as Ribonuclease Active-Site Model Systems: Structural Changes and Solvent Effects

Design and synthesis of substrate-based inhibitors of botulinum neurotoxin type B metalloprotease

Design, synthesis and evaluation of MCH receptor 1 antagonists—Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414

Design, synthesis and evaluation of MCH receptor 1 antagonists—Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition

Design, synthesis and evaluation of MCH receptor 1 antagonists—Part III: Discovery of pre-clinical development candidate BI 186908

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR

Discovery of Aminoglycoside Mimetics by NMR-Based Screening of Escherichia c oli A-site RNA

Discovery of Aminoglycoside Mimetics by NMR-Based Screening of Escherichia coli A-site RNA

Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer

Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Inhibitors of Anti-apoptotic Proteins for Cancer Therapy

Managing erosion of mangrove-mud coasts with permeable dams – lessons learned

Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties

Potent, selective inhibitors of protein tyrosine phosphatase 1B

Regio- and diastereo-selectivity of the insertion of aldehydes into alkyne zirconocene complexes

Sequencing Hydroxyethylamine-Containing Peptides via Edman Degradation

Structural Basis for BABIM Inhibition of Botulinum Neurotoxin Type B Protease

Structural Basis for BABIM Inhibition of Botulinum Neurotoxin Type B Protease [J. Am. Chem. Soc. 2000, 122, 11268−11269]

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

Synthesis of RNAse active site model systems using a steroid template

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