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Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

Archives of Toxicology. Archiv für Toxikologie, 2015-09, Vol.89 (9), p.1401-1438

2015

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Understanding Key Mechanisms of Exercise-Induced Cardiac Protection to Mitigate Disease: Current Knowledge and Emerging Concepts

Physiological reviews, 2018-01, Vol.98 (1), p.419-475

2018

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Ibrutinib increases the risk of atrial fibrillation, potentially through inhibition of cardiac PI3K-Akt signaling

Blood, 2014-12, Vol.124 (25), p.3829-3830

2014

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miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart

Future medicinal chemistry, 2015-01, Vol.7 (13), p.1771-1792

2015

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Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy

PloS one, 2014-02, Vol.9 (2), p.e90337-e90337

2014

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Clusterin is regulated by IGF1–PI3K signaling in the heart: implications for biomarker and drug target discovery, and cardiotoxicity

Archives of toxicology, 2020-05, Vol.94 (5), p.1763-1768

2020

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The IGF1-PI3K-Akt Signaling Pathway in Mediating Exercise-Induced Cardiac Hypertrophy and Protection

Advances in experimental medicine and biology, 2017, Vol.1000, p.187-210

2017

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HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

Epigenetics, 2015-05, Vol.10 (5), p.418-430

2015

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Therapeutic silencing of miR‐652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy

The FASEB journal, 2014-12, Vol.28 (12), p.5097-5110

2014

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Sex differences in response to miRNA‐34a therapy in mouse models of cardiac disease: identification of sex‐, disease‐ and treatment‐regulated miRNAs

The Journal of physiology, 2016-10, Vol.594 (20), p.5959-5974

2016

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Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes

Diabetes (New York, N.Y.), 2021-01, Vol.70 (1), p.255-261

2021

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Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets

Cell reports (Cambridge), 2018-09, Vol.24 (10), p.2757-2772

2018

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The therapeutic potential of miRNAs regulated in settings of physiological cardiac hypertrophy

Future medicinal chemistry, 2014-02, Vol.6 (2), p.205-222

2014

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Translational Potential of Non-coding RNAs for Cardiovascular Disease

Non-coding RNAs in Cardiovascular Diseases, p.343-354

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The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

Nature communications, 2014-12, Vol.5 (1), p.5705-5705, Article 5705

2014

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Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2018-03, Vol.1863 (3), p.219-234

2018

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Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload

Scientific reports, 2016-03, Vol.6 (1), p.22442-22442, Article 22442

2016

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A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing

Bioscience reports, 2011-10, Vol.31 (5), p.333-343

2011

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Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases

RNA biology, 2017-05, Vol.14 (5), p.500-513

2017

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Dynamic changes in the cardiac methylome during postnatal development

The FASEB journal, 2015-04, Vol.29 (4), p.1329-1343

2015

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The Interplay of Protein Coding and Non-Coding RNAs (circRNAs, lncRNAs) During Cardiac Differentiation

EBioMedicine, 2017-11, Vol.25 (C), p.9-10

2017

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Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice

Nature Cardiovascular Research, 2023-03, Vol.2 (3), p.268-289

2023

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MicroRNAs differentially regulated in cardiac and skeletal muscle in health and disease: Potential drug targets?

Clinical and experimental pharmacology & physiology, 2014-09, Vol.41 (9), p.727-737

2014

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Therapeutic potential of targeting microRNAs to regulate cardiac fibrosis: miR-433 a new fibrotic player

Annals of translational medicine, 2016-12, Vol.4 (24), p.548-548

2016

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The yin and yang of adaptive and maladaptive processes in heart failure

Drug discovery today. Therapeutic strategies, 2012, Vol.9 (4), p.e163-e172

2012

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Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

Understanding Key Mechanisms of Exercise-Induced Cardiac Protection to Mitigate Disease: Current Knowledge and Emerging Concepts

Ibrutinib increases the risk of atrial fibrillation, potentially through inhibition of cardiac PI3K-Akt signaling

miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy

Clusterin is regulated by IGF1–PI3K signaling in the heart: implications for biomarker and drug target discovery, and cardiotoxicity

The IGF1-PI3K-Akt Signaling Pathway in Mediating Exercise-Induced Cardiac Hypertrophy and Protection

HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

Therapeutic silencing of miR‐652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy

Sex differences in response to miRNA‐34a therapy in mouse models of cardiac disease: identification of sex‐, disease‐ and treatment‐regulated miRNAs

Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes

Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets

The therapeutic potential of miRNAs regulated in settings of physiological cardiac hypertrophy

Translational Potential of Non-coding RNAs for Cardiovascular Disease

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies

Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload

A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing

Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases

Dynamic changes in the cardiac methylome during postnatal development

The Interplay of Protein Coding and Non-Coding RNAs (circRNAs, lncRNAs) During Cardiac Differentiation

Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice

MicroRNAs differentially regulated in cardiac and skeletal muscle in health and disease: Potential drug targets?

Therapeutic potential of targeting microRNAs to regulate cardiac fibrosis: miR-433 a new fibrotic player

The yin and yang of adaptive and maladaptive processes in heart failure

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