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Challenges in accurate quantitation of lysophosphatidic acids in human biofluids

Journal of lipid research, 2014-08, Vol.55 (8), p.1784-1796

2014

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Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases[S]

Journal of lipid research, 2017-06, Vol.58 (6), p.1091-1099

2017

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Quantification of 4-Beta-Hydroxycholesterol in Human Plasma Using Automated Sample Preparation and LC-ESI-MS/MS Analysis

Chemical research in toxicology, 2011-09, Vol.24 (9), p.1575-1585

2011

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Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS[S]

Journal of lipid research, 2015-03, Vol.56 (3), p.747-753

2015

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Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.18102-18113

2021

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Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists

Bioorganic & medicinal chemistry letters, 2021-10, Vol.50, p.128325-128325, Article 128325

2021

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Design and preparation of N-linked hydroxypyridine-based APJ agonists

Bioorganic & medicinal chemistry letters, 2022-10, Vol.73, p.128882-128882, Article 128882

2022

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Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase

Bioorganic & medicinal chemistry, 2020-11, Vol.28 (22), p.115723-115723, Article 115723

2020

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Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3086-3099

2021

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Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ

Bioorganic & medicinal chemistry letters, 2020-04, Vol.30 (7), p.126955-126955, Article 126955

2020

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Identification of 6‑Hydroxypyrimidin-4(1H)‑one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists

ACS medicinal chemistry letters, 2021-11, Vol.12 (11), p.1766-1772

2021

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Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL‑C Increase In Vivo

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1660-1670

2020

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Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents

Analytical biochemistry, 2019-03, Vol.568, p.41-50

2019

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Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors

Bioorganic & medicinal chemistry letters, 2018-12, Vol.28 (23-24), p.3721-3725

2018

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Applications of HILIC for targeted and non-targeted LC/MS analyses in drug discovery

Journal of separation science, 2010-03, Vol.33 (6-7), p.923-929

2010

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Selected Reaction Monitoring LC−MS Determination of Idoxifene and Its Pyrrolidinone Metabolite in Human Plasma Using Robotic High-Throughput, Sequential Sample Injection

Analytical chemistry (Washington), 2001-01, Vol.73 (1), p.119-125

2001

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PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.673-678

2018

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Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin, a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor

International journal of toxicology, 2013-09, Vol.32 (5), p.336-350

2013

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A novel method for the determination of 1,5-anhydroglucitol, a glycemic marker, in human urine utilizing hydrophilic interaction liquid chromatography/MS

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-10, Vol.873 (2), p.144-150

2008

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Liquid-liquid extraction coupled with LC/MS/MS for monitoring of malonyl-CoA in rat brain tissue

Analytical and bioanalytical chemistry, 2010-08, Vol.397 (7), p.3137-3142

2010

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Enantioselective liquid chromatography–mass spectrometry assay for the determination of ifosfamide and identification of the N-dechloroethylated metabolites of ifosfamide in human plasma

Journal of pharmaceutical and biomedical analysis, 2007-10, Vol.45 (2), p.295-303

2007

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Synthesis of [D4]- and [D7]-4β-hydroxycholesterols for use in a novel drug-drug interaction assay

Journal of labelled compounds & radiopharmaceuticals, 2012-02, Vol.55 (2), p.61-65

2012

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A novel method for the determination of 1,5-anhydroglucitol, a glycemic marker, in human urine utilizing hydrophilic interaction liquid chromatography/MS 3

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-10, Vol.873 (2), p.144-150

2008

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Pyridoxamine, an Inhibitor of Advanced Glycation Reactions, Also Inhibits Advanced Lipoxidation Reactions

The Journal of biological chemistry, 2000-07, Vol.275 (28), p.21177-21184

2000

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Challenges in accurate quantitation of lysophosphatidic acids in human biofluids

Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases[S]

Quantification of 4-Beta-Hydroxycholesterol in Human Plasma Using Automated Sample Preparation and LC-ESI-MS/MS Analysis

Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS[S]

MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity

Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure

Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists

Design and preparation of N-linked hydroxypyridine-based APJ agonists

Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase

Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate

Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ

Identification of 6‑Hydroxypyrimidin-4(1H)‑one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL‑C Increase In Vivo

Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors

Applications of HILIC for targeted and non-targeted LC/MS analyses in drug discovery

Selected Reaction Monitoring LC−MS Determination of Idoxifene and Its Pyrrolidinone Metabolite in Human Plasma Using Robotic High-Throughput, Sequential Sample Injection

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin, a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor

A novel method for the determination of 1,5-anhydroglucitol, a glycemic marker, in human urine utilizing hydrophilic interaction liquid chromatography/MS

Liquid-liquid extraction coupled with LC/MS/MS for monitoring of malonyl-CoA in rat brain tissue

Enantioselective liquid chromatography–mass spectrometry assay for the determination of ifosfamide and identification of the N-dechloroethylated metabolites of ifosfamide in human plasma

Synthesis of [D4]- and [D7]-4β-hydroxycholesterols for use in a novel drug-drug interaction assay

A novel method for the determination of 1,5-anhydroglucitol, a glycemic marker, in human urine utilizing hydrophilic interaction liquid chromatography/MS 3

Pyridoxamine, an Inhibitor of Advanced Glycation Reactions, Also Inhibits Advanced Lipoxidation Reactions

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