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Why classical receptor theory, which ignores allostery, can effectively measure the strength of an allosteric effect as agonist's efficacy

British journal of pharmacology, 2024-06, Vol.181 (12), p.1757-1767

2024

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Community guidelines for GPCR ligand bias: IUPHAR review 32

British journal of pharmacology, 2022-07, Vol.179 (14), p.3651-3674

2022

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What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling

Trends in pharmacological sciences (Regular ed.), 2014-12, Vol.35 (12), p.639-647

2014

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Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach

Scientific reports, 2017-03, Vol.7 (1), p.44247-44247, Article 44247

2017

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Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors

Scientific reports, 2020-06, Vol.10 (1), p.9111, Article 9111

2020

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Conceptual and experimental issues in biased agonism

Cellular signalling, 2021-06, Vol.82, p.109955-109955, Article 109955

2021

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Biased agonism at G protein-coupled receptors

Cellular signalling, 2021-07, Vol.83, p.109981-109981, Article 109981

2021

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Cell Contact-dependent Functional Selectivity of β2-Adrenergic Receptor Ligands in Stimulating cAMP Accumulation and Extracellular Signal-regulated Kinase Phosphorylation

The Journal of biological chemistry, 2012-02, Vol.287 (9), p.6362-6374

2012

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Where have all the active receptor states gone?

Nature chemical biology, 2012-07, Vol.8 (8), p.674-677

2012

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Ligands Raise the Constraint That Limits Constitutive Activation in G Protein-coupled Opioid Receptors

The Journal of biological chemistry, 2013-08, Vol.288 (33), p.23964-23978

2013

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Allosteric coupling and conformational fluctuations in proteins

Current protein & peptide science, 2009-04, Vol.10 (2), p.110-115

2009

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Agonist‐directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid artery

British journal of pharmacology, 2002-05, Vol.136 (2), p.171-176

2002

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Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand

Molecular pharmacology, 1992-03, Vol.41 (3), p.549-560

1992

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Partial Rescue of Functional Interactions of a Nonpalmitoylated Mutant of the G-Protein Gαs by Fusion to the β-Adrenergic Receptor

Biochemistry (Easton), 2003-03, Vol.42 (9), p.2607-2615

2003

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Long and short distance movements of β2-adrenoceptor in cell membrane assessed by photoconvertible fluorescent protein dendra2–β2-adrenoceptor fusion

Biochimica et biophysica acta. Molecular cell research, 2011-08, Vol.1813 (8), p.1511-1524

2011

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Acidic pH induces fusion of cells infected with baculovirus to form syncytia

FEBS letters, 1992-06, Vol.304 (2), p.221-224

1992

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Agonist efficacy and allosteric models of receptor action

Annals of the New York Academy of Sciences, 1997-05, Vol.812, p.98-115

1997

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β 2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low density membrane fractions

European journal of pharmacology, 2010, Vol.630 (1), p.42-52

2010

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Ca2+-Induced Inhibition of Adenylyl Cyclase in Turkey Erythrocyte Membranes

Pharmacology, 1998-10, Vol.57 (4), p.222-228

1998

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β2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low density membrane fractions

European journal of pharmacology, 2010-03, Vol.630 (1-3), p.42-52

2010

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Quasi-irreversible binding of agonist to β-adrenoceptors and formation of non-dissociating receptor-Gs complex in the absence of guanine nucleotides

European journal of pharmacology, 2001-08, Vol.425 (3), p.181-188

2001

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Guanine Nucleotide Exchange-Independent Activation of G s Protein by β 2 -Adrenoceptor

Molecular pharmacology, 2005-09, Vol.68 (3), p.720-728

2005

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Guanine nucleotide exchange-independent activation of Gs protein by beta2-adrenoceptor

Molecular pharmacology, 2005-09, Vol.68 (3), p.720-728

2005

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Long and short distance movements of β(2)-adrenoceptor in cell membrane assessed by photoconvertible fluorescent protein dendra2-β(2)-adrenoceptor fusion

Biochimica et biophysica acta, 2011-08, Vol.1813 (8), p.1511

2011

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Atypical schild plots with histamine H1 receptor agonists and antagonists in the rabbit aorta

European journal of pharmacology, 1991-05, Vol.197 (1), p.49-56

1991

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Why classical receptor theory, which ignores allostery, can effectively measure the strength of an allosteric effect as agonist's efficacy

Community guidelines for GPCR ligand bias: IUPHAR review 32

What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling

Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach

Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors

Conceptual and experimental issues in biased agonism

Biased agonism at G protein-coupled receptors

Cell Contact-dependent Functional Selectivity of β2-Adrenergic Receptor Ligands in Stimulating cAMP Accumulation and Extracellular Signal-regulated Kinase Phosphorylation

Where have all the active receptor states gone?

Ligands Raise the Constraint That Limits Constitutive Activation in G Protein-coupled Opioid Receptors

Allosteric coupling and conformational fluctuations in proteins

Agonist‐directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid artery

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand

Partial Rescue of Functional Interactions of a Nonpalmitoylated Mutant of the G-Protein Gαs by Fusion to the β-Adrenergic Receptor

Long and short distance movements of β2-adrenoceptor in cell membrane assessed by photoconvertible fluorescent protein dendra2–β2-adrenoceptor fusion

Acidic pH induces fusion of cells infected with baculovirus to form syncytia

Agonist efficacy and allosteric models of receptor action

β 2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low density membrane fractions

Ca2+-Induced Inhibition of Adenylyl Cyclase in Turkey Erythrocyte Membranes

β2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low density membrane fractions

Quasi-irreversible binding of agonist to β-adrenoceptors and formation of non-dissociating receptor-Gs complex in the absence of guanine nucleotides

Guanine Nucleotide Exchange-Independent Activation of G s Protein by β 2 -Adrenoceptor

Guanine nucleotide exchange-independent activation of Gs protein by beta2-adrenoceptor

Long and short distance movements of β(2)-adrenoceptor in cell membrane assessed by photoconvertible fluorescent protein dendra2-β(2)-adrenoceptor fusion

Atypical schild plots with histamine H1 receptor agonists and antagonists in the rabbit aorta

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