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In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets

Nucleic acids research, 2018-09, Vol.46 (16), p.8385-8403

2018

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The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

Biochemistry (Easton), 2010-01, Vol.49 (2), p.393-400

2010

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Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture

Toxicological sciences, 2014-08, Vol.140 (2), p.283-297

2014

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Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

The Journal of pharmacology and experimental therapeutics, 2007-01, Vol.320 (1), p.72-80

2007

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Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor

Toxicological sciences, 2011-04, Vol.120 (2), p.381-391

2011

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Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration

Toxicology letters, 2012-11, Vol.214 (3), p.314-319

2012

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Activation of the Constitutive Androstane Receptor by Monophthalates

Chemical research in toxicology, 2016-10, Vol.29 (10), p.1651-1661

2016

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Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues

Toxicology and applied pharmacology, 2007-07, Vol.222 (1), p.42-56

2007

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Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor

Biochemical journal, 2014-02, Vol.458 (1), p.95-107

2014

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Di(2-ethylhexyl) phthalate Is a Highly Potent Agonist for the Human Constitutive Androstane Receptor Splice Variant CAR2

Molecular pharmacology, 2009-05, Vol.75 (5), p.1005-1013

2009

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Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities

Toxicological sciences, 2011-03, Vol.120 Suppl 1 (Supplement 1), p.S49-S75

2011

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Aryl‐hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver

Hepatology (Baltimore, Md.), 2007-07, Vol.46 (1), p.209-218

2007

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Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

Toxicological sciences, 2010-05, Vol.115 (1), p.89-97

2010

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Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

Critical reviews in toxicology, 2014-01, Vol.44 (1), p.64-82

2014

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Differentiation of human embryonic stem cells along a hepatic lineage

Chemico-biological interactions, 2011-03, Vol.190 (1), p.62-72

2011

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Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes

Experimental cell research, 2004-01, Vol.292 (2), p.252-264

2004

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Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression

The Journal of biological chemistry, 2016-07, Vol.291 (29), p.15378-15387

2016

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Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter

Biochimica et biophysica acta, 2014-06, Vol.1839 (6), p.493-505

2014

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Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism

Journal of proteome research, 2019-01, Vol.18 (1), p.239-251, Article acs.jproteome.8b00566

2019

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The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter

The Journal of pharmacology and experimental therapeutics, 2009-07, Vol.330 (1), p.23-30

2009

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Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter

Gene, 2014-02, Vol.536 (1), p.135-144

2014

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The molecular basis of the human serum paraoxonase activity polymorphism

Nature genetics, 1993-01, Vol.3 (1), p.73-76

1993

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Δ(9)-Tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor β (ERβ)

Chemical research in toxicology, 2013-07, Vol.26 (7), p.1073

2013

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Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells

Toxicology (Amsterdam), 2014-12, Vol.326, p.18

2014

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Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes

Drug metabolism and disposition, 2009-12, Vol.37 (12), p.2323-2329

2009

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In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration

Activation of the Constitutive Androstane Receptor by Monophthalates

Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues

Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor

Di(2-ethylhexyl) phthalate Is a Highly Potent Agonist for the Human Constitutive Androstane Receptor Splice Variant CAR2

Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities

Aryl‐hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

Differentiation of human embryonic stem cells along a hepatic lineage

Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes

Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression

Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter

Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism

The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter

Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter

The molecular basis of the human serum paraoxonase activity polymorphism

Δ(9)-Tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor β (ERβ)

Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells

Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes

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